How long to wait before trying different meds?

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Regular Member

Date Joined Nov 2006
Total Posts : 204
   Posted 6/17/2008 11:04 AM (GMT -6)   
I was diagnosed with UP a few years ago. Since then, apparently it's gone into full UC throughout my colon. Fun times! I recently had a colonoscopy that confirmed this through a new GI doc. We're now trying out Lialda as our first step at treatment before moving onto something new.

Just curious to know how long people typically wait before moving onto a different medication? He told me that the 5ASA drugs are all similar but people react differently to each so no two are neccessarily the same.

I'm doing a bit better on the Lialda, but that may be because I'm smoking again. Seems like things got worse when I quit smoking. My main symptoms still are a gurgling feeling in my colon, mucus, minor blood, and rectal pain. I asked if I should be taking suppositories which I was prescribed years ago and he said we'd check into that at the next visit, but for now to just stick with the Lialda since it can hit that far down through distribution. His theory of rectal burning was due to the fast transit of food through the colon and too much acidity hitting the rectum. We'll see...

Currently taking 4 lialda a day.

Regular Member

Date Joined Oct 2007
Total Posts : 348
   Posted 6/17/2008 11:38 AM (GMT -6)   
How about rectal meds? I was on Asacol for 2 longs years of a terrible flare with no positive results. I will never stay on a med that long again before trying something new. I just figured my UC was so bad at the time that nothing would help unless I tried the stronger meds. Just as my GI was about to put me on 6mp, I asked about going onto Sulfasalazine which worked for me years ago. She said "ok" and bingo, that is working for me. (makes me wonder if my UC spread further because the meds were not working) If you don't see any results after a few months, I would ask about something else. I would definitely look into some rectal meds also. Good Luck.

diagnosed with uc 27 years ago.  Enojoyed 20 year remission with just minor blips here and there (approximately 16 of those years without any meds)
In a flare for 2 very long years which Asacol didn't help at all.  Finally in remission again since Jan 2008, can't believe it..............
currently on Sulfasalazine 2 tabs 3x day. Folic acid, mesalamine enema once every 5th day. Omega 3, Probiotics, multi vitamin, calcium supplement, Biotin....

Regular Member

Date Joined Nov 2006
Total Posts : 204
   Posted 6/17/2008 11:42 AM (GMT -6)   
I will look into the rectal route. I wish I could just take suppositories but I don't imagine that to hit the entire colon. Maybe a combination of the lialda and canasa?

The only bummer about rectal meds is I would hate having to do an enema every night. Years ago I tried enemas for the proctitis but didn't react well to it after the fourth or fifth night. Seemed to make me feel more cramped and had more frequent bowel movements.

Concerned Wife in WA
Regular Member

Date Joined Jun 2008
Total Posts : 37
   Posted 6/17/2008 11:51 AM (GMT -6)   

I was wondering the same thing. The doc put Jim on the 6MP last week. He is still feeling worse than he was. Still losing weight. She called and left a message this morning that the blood test came back still high on the liver function. She is now gone for 2 weeks on vacation. We are debating on taking him off that and leaving him just on the asacol and prednisone as he isn't any better on the 6MP. Any thoughts appreciated.
44 y/o Crab Fisherman in Alaska

Diagnosed May 2008
Mesalamine 12 pills daily
Prednisone 40 mg

Taking multiple vitamin supplements, lots of omega 3's and Antioxidants

Elite Member

Date Joined May 2003
Total Posts : 30195
   Posted 6/17/2008 12:48 PM (GMT -6)   
Rectal meds are not meant to treat the entire that's not even a thought you need to revisit. Rectal meds are meant to deal with the inflammation in that area...quick and effectively. Retention enemas will go as high as the sigmoid and maybe farther.

Remember that rectal symptoms will be worse since that's where UC starts....keep that in'll be the first place to start (you had UP)'s the last place to heal. It will help that poor area which gets the most assult through having stool or diarrhea forced through the raw inflamed area (add all the wiping as well).

You should be on them....the Lialda isn't meant to deal with the entire colon...when one has diarrhea or inflammation in the colon, sometimes it's not fully dispursed and will be forced out with the stool/diarrhea.

Call the doc and request the suppositories at least....I don't understand him allowing you discomfort.

If he doesn't give you any and forces you to WAIT till your next appointment (when is that by the way?)...pure torture on purpose from my perspective.....go to the store and see if you can purchase any low dosage hydrocortisone suppositories. It'll be better than nothing.

Call the doc and should be using both oral and rectal 5ASA meds.

*Heather*Status: mini flare Dec 28... tapered to every 4th night
~diagnosed January 1989 UC (proctosigmoiditis)
~5ASA: Asacol (6 daily) + Salofalk enemas (increase for flares tapered to maintenance)
~Bentylol (dicyclomine) 20mg as needed
~Probiotic 3(Natural Factors Protec) bedtime + 1 (Primadophilus Reuteri) occasionally
~multi-digestive enzymes as needed ....zymactive 3 - 5x daily
~Ranitidine,Pariet (reflux) Effexor XR 75mg;  Pulmicort/Airomir (asthma)
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS"  worth it !!!

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