Can prednisone just stop working?

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Regular Member

Date Joined May 2008
Total Posts : 47
   Posted 6/19/2008 12:43 PM (GMT -6)   
I have been flaring since mid may and have been taking 40mg of prednisone. I was responding well as far as the bleeding goes. I was having pretty normal stool with a little blood from time to time. I was having stomach pain, but I seemed to be getting better otherwise. I tapered to 30 mg for almost two weeks and things were still going well. Then a few days ago I started with the bloody d again and I don't know how this happened. I have been eating pretty bland food and haven't done anything out of the ordinary. I'm so frustrated! Is it possible for prednisone to just stop working? Has anyone else experienced this?
20. Female. California.
Diagnosed left sided Ulcerative Colitis at 15, first symptoms at age 11.

40mg prednisone daily. (Been on prednisone 5mg-40mg for the past year)
Now down to 30mg

Multi Vitamin
Digestive Advantage Chrons and Colitis
Iron Supplement
Allergic to- 6mp, Asacol

Veteran Member

Date Joined Jul 2007
Total Posts : 2148
   Posted 6/19/2008 1:12 PM (GMT -6)   
I think this can happen when we are tapering, it may mean you are steriod dependant, I would contact your GI.

I am going to try my second taper, last time I got down to 5mg but started bleeding 2 days after I took aspirin, so I don't know if I am 'steriod dependant' and the imuran is not working for me and I need to go to remicade or if it was the aspirin that caused my flare.

I just went back up to 40mg a week ago and am doing much better, I want to stay at 40 for a couple of weeks if/once I reach remission and then will taper by 10mg a week to 20mg a week then taper by 5mg a week until I reach 5mg where I have to stay for my kidney disease.
Beth, 32 ~ small flare - hoping caused by aspirin - hydrocortisone e's
Major Flare Sept/Oct 07
UC dx'd 03/00 (Proctosigmoiditis); Pancolitis since 09/07
Azathioprine 200mg 1xday nightly; Calcium and Vit D 500mg 3xday, Multi Vit, Folic Acid 400mg 2xday, Prilosec, Probiotics.
Minimal Change Disease (Kidney Disorder) dx'd 09/07 - partial remission since 03/08
Prednisone 40mg 1xday, Simvastatin 20mg 1xday, Diovan 160mg 2xday. Tekturna 150mg 1xday, Fosomax 70mg 1xweek. MCD may be from hypersensitivty to 5ASA drugs.  Do you have edema? If so, check your blood protien level!

Scrap Girl
Veteran Member

Date Joined Jan 2007
Total Posts : 653
   Posted 6/19/2008 2:56 PM (GMT -6)   
Also, going from 40 to 30 may have been too much of a drop. You might need to taper down slower like maybe 5 mg at a time.
Diagnosed with UC in Feb. 2005
Colazal (9 a day)
Folic Acid

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