Prednisone Moods and Antidepressents

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Kevin C
Regular Member

Date Joined Aug 2004
Total Posts : 57
   Posted 6/20/2008 8:04 PM (GMT -6)   
I'm hoping that somebody can help me with this question. I started a flare after being in remission for about 2 years. I had no choice but to start the dreaded prednisone again. 20 mg a day for about a month and all of the awful side effects are coming back, including what I call the pred moods. I need a way to stop these horrible feelings of anxiety, anger, depression etc.
My question is.... do antidepressants help with these moods? Does anybody have experience with this?

Regular Member

Date Joined Jun 2008
Total Posts : 57
   Posted 6/20/2008 9:02 PM (GMT -6)   
Hi Kevin,

I've been on prednisone a few times, and have had lots of the side effects, but my mood has never been TOO affected by it (although my husband will tell you otherwise). I'm not sure if antidepressants would help, but I would talk to your doc asap about it. My good friend had to be taken off of pred. immediately because it was so severely affecting her mood. Good luck, and feel better.
*Diagnosed 10/07 (6 months pregnant w/ 2nd baby)
*Asacol (4 pills 3x a day)
Calcium, multivitamin, Metamucil

Veteran Member

Date Joined Apr 2006
Total Posts : 3402
   Posted 6/20/2008 9:53 PM (GMT -6)   
I'm not sure if an AD would help with the pred moods. Definitely worth asking your GP about!
Pan-colitis and GERD diagnosed May 2003
Osteopenia (hip and spine) diagnosed Feb 2006
Status:  close to remission?!?!?
25mg Pred, Asacol 12 per day,  Azathioprine 100mg, Aciphex, Forvia, and Pro-Bio
1st Remicade infusion:  06/17/08
Co-Moderator for the UC forum:  Keep HealingWell running smoothly:

Veteran Member

Date Joined Feb 2006
Total Posts : 5698
   Posted 6/20/2008 10:59 PM (GMT -6)   

yes you can find ADs help with pred depression.  It was offered to me when I had a 2 year course of prednisone and got very depressed.  I opted not to take ADs due to the reason that I thought it was pred induced.  After I ceased taking pred I still had the depression and then started taking them.  My GI was very much in favor of putting his mood altered pred patient on ADs. 



dx proctitis in 1987
dx UC in 1991, was stable until 1998

1998 started prednisone, asacol, pentasa, nortriptylene, ativan, 6MP, rowasa enemas and suppositories, hydrocortisone enemas, tried the SCD diet, being a vegetarian, omega 3s, flax, pranic healing, yoga, acupuncture, probiotics

2000 lost all my B-12 stores and became anemic

2001 opted for j-pouch surgery- now living life med-free

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