new form of meslazine - much better imo

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kazygirl
Veteran Member


Date Joined Sep 2007
Total Posts : 955
   Posted 6/21/2008 4:57 AM (GMT -6)   
well, maybe not super new, but semi-new...
i've been prescribed mesalazine (salofalk or pentasa) granules.
 
i have been researching it on the net today and found that it is a far superior way to take mesalazine instead of the tablets.
taking so many tablets a day of mesalazine has been indicated to cause exacerbation of UC.  even though it is made specifically for UC.
The vanilla-flavoured granule formulation is easy to swallow and allows for simpler dosing thereby improving compliance, particularly with the larger doses of mesalazine needed to manage this condition. The unique layered granule formulation both delays release of mesalazine until the granules reach the higher pH ileal-caecal region of the GI tract, and prolongs it over several hours. Furthermore the mesalazine granules allows uniform distribution over the inflamed intestinal mucosa, systemic absorption is low, reducing potential side effects.  Non-compliance can lead to a disease exacerbation.
anyhoo, something to maybe ask your doctors about since it takes you down to one dose a day that equals 12 or so pills.
hope it helps!
they taste alright too.  no gagging. woohoo.
 
here is just one link about a study done on it http://www.pulsus.com/cddw2008/abs/323.htm
 
-----
imo = in my opinion (in case you were wondering what that meant)
steph - 32 - female - UC since 2000
currently flaring again..  grrr!
 
 
 


AlabamaBabs
Regular Member


Date Joined Jul 2007
Total Posts : 172
   Posted 6/21/2008 8:01 AM (GMT -6)   
Kazygirl, that's pretty interesting. How big are granules? Do you just take them with water and do they dissolve in the GI tract? Thanks!
AlabamaBabs
Pancolitis diagnosed 5/07 and started 2 Lialda/day;
increased to 4 Lialda/day since 8/01/07
Started 40 mg. Prednisone on 9/16/07 and DONE as of 11/26/07!Canasa suppositories 1000mg as needed
 


jujub
Elite Member


Date Joined Mar 2003
Total Posts : 10407
   Posted 6/21/2008 8:38 AM (GMT -6)   
Just a quick note: this isn't actually Asacol, it's Pentasa. Same drug, but Pentasa is formulated to be effective at the very beginning of the colon, so may be less effective for treating the left side of the colon, rectum and sigmoid.
Judy
 
Moderate to severe left-sided UC (21 cm) diagnosed 2001.
Avascular necrosis in both shoulders is my "forever" gift from steroid therapy.
Colazal,  Remicade, Nature's Way Primadophilus Reuteri. In remission since April, 2006.
 
Co-Moderator UC Forum
Please remember to consult your health care provider when making health-related decisions.


quincy
Elite Member


Date Joined May 2003
Total Posts : 30999
   Posted 6/21/2008 12:10 PM (GMT -6)   
The granules aren't available in the US or Canada...as well as the foam enemas, unfortunately. I think having all the options of different forms would allow better options of delivery.

Medications such as Asacol and ilk are many times prescribed in a high dosage which can give side effects that exacerbate some UC symptoms. Starting at a lower dosage and increasing would be a better way to avoid some of those symptoms.

Compliance is a huge part of success with medications...If they're sweetened with artificial sweeteners, that in itself could cause problems.

Rectal meds are highly neglected by doctors, and compliance by patients seems adequate at best. Can't express enough that not using them (or at least allowing them a fair trial) can give the impression of oral med failure.

It would be nice if we all had the same options of meds...

quincy

quincy
*Heather*Status: mini flare Dec 28... tapered to every 4th night
~diagnosed January 1989 UC (proctosigmoiditis)
~5ASA: Asacol (6 daily) + Salofalk enemas (increase for flares tapered to maintenance)
~Bentylol (dicyclomine) 20mg as needed
~vitamins/minerals/supplements 
~Probiotic 3(Natural Factors Protec) bedtime + 1 (Primadophilus Reuteri) occasionally
~multi-digestive enzymes as needed ....zymactive 3 - 5x daily
~Ranitidine,Pariet (reflux) Effexor XR 75mg;  Pulmicort/Airomir (asthma)
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS"  worth it !!!


kazygirl
Veteran Member


Date Joined Sep 2007
Total Posts : 955
   Posted 6/21/2008 9:59 PM (GMT -6)   
i mentioned in the my first post that it is pentasa or salofalk as the brands. i didnt mention asacol. i dont even know what that is being over here in australia.

that is unfortunate that you cant get it in america.

you empty the sachet of granules onto the tongue and wash it down with water or juice. they are like the little candy dots on donuts or cupcakes. that size. and taste sweet. very easy to take.

they make it ALL the way into the colon and are made to disperse evenly throughout the WHOLE colon to the end.
NOT just the beginning. the pills only go part way, hence the switch to the granules, so they go all the way.

my doc wants me to take the salofalk enemas but they make me very sick and i cant tolerate them. so he did try.

these granules are so much better than taking a million pills a day. i quite like them and am hopeful as the studies on them seem to be very very promising.
steph - 32 - female - UC since 2000
currently flaring again..  grrr! (triggered by stress - grrr)
mesalazine granules 3g x1 a day (much nicer than a million tablets a day)
enteric coated fish oil -omega 3 (so they get all the way to my colon)
vitamin D3 x1 a day
prednisolone 25mg x1 a day (ick ick and did i say ick?)
tumeric capsules x3 a day
 
 
 


jujub
Elite Member


Date Joined Mar 2003
Total Posts : 10407
   Posted 6/21/2008 10:34 PM (GMT -6)   

Asacol is the same drug as Salofalk.

Sounds like a more pleasant way to take medication, for sure.


Judy
 
Moderate to severe left-sided UC (21 cm) diagnosed 2001.
Avascular necrosis in both shoulders is my "forever" gift from steroid therapy.
Colazal,  Remicade, Nature's Way Primadophilus Reuteri. In remission since April, 2006.
 
Co-Moderator UC Forum
Please remember to consult your health care provider when making health-related decisions.

Post Edited (Judilyn) : 6/21/2008 11:40:11 PM (GMT-6)


Severin
Regular Member


Date Joined Oct 2007
Total Posts : 320
   Posted 6/21/2008 11:25 PM (GMT -6)   
I was taking the granules for 8 months and we discovered that it was making my UC worse, though I seem to have a bad reaction all the Mesalazine family of drugs.

The only one I seem to tolerate well is Colazide (Colazal in the US) which is based on Balsalazide.
"We are dreamers, shapers, singers and makers..." - Elric, Technomage
  • 28yo male. Brisbane, Australia. Diagnosed at 16yo. Currently enjoying severe pan-colitis.
    - Participating in the Golimumab trial as of 1st May, 2008;
    - 2x Colazide, twice a day; 25mg of 6-MP a day; 1xAllopurnol;
    - 1x teaspoon of Metamucil 3 times a day;
    - 3x Garlic oil capsules & 7mL Olive Leaf Extract twice a day.


JerryGarcia
Regular Member


Date Joined Feb 2008
Total Posts : 68
   Posted 6/22/2008 5:35 AM (GMT -6)   
Can you get these in the UK?
DX with UC Jan 07
Currently taking Colazide (allergic to Asacol and Pentasa) 6 a day
Also taking VSL3 X1 a day


princesscolon
Veteran Member


Date Joined Apr 2006
Total Posts : 733
   Posted 6/22/2008 9:23 PM (GMT -6)   
Thanks for the info, kazygirl. I wish I could try it but I am in the U.S.
Diagnosed with Left-sided UC in 1995 at age 15, Prednisone, Rowasa & Hydrocort. Enemas, Proctofoam, Sulfasalazine, Asacol, Probiotics, Fish Oil, Aloe Juice, Canasa, Enotcort, Colazol, Anamantle, Remicade, etc... had 1 inch deep rectal ulcer 2004, put on Remicade, August 2007:Increased Remicade dosage-700mg every 6 weeks,diagnosed w/ Psoriatic Arthritis & Fibromyalgia Current meds: Clorazepate, Lomotil,  Tylenol pm, Lyrica started 1/17/08,  Humira started 4/4/08

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