Try breaking up the dose throughout the day. When I'm on Prednisone, I can't take it once a day like my doctor prescribed. If I'm on 40 mg, I take 10 mg - 4x a day. If I'm on 20 mg, I take 5 mg - 4x a day. My body tolerates it much better because it stays consistently in my body. Before I tried taking it this way, I would get really sick a few hours before I was due to take my dose so breaking it up made that stop.
Female, Age 37
Diagnosed w/c.diff 7/02 when pregnant w/1st and only child during 2nd trimester(wasn't on antibiotics)
C.diff flare within weeks of delivering baby 1/03
Diagnosed with UC 2/03
Cortenema as needed