Lialda 4X a day! Should it be taken on an empty stomach?

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Regular Member

Date Joined Mar 2007
Total Posts : 125
   Posted 6/22/2008 8:35 PM (GMT -6)   
Hi everyone,

I've been on Lialda for three months and take it with no food at 6:30 every morning. I've had UC/UP for about 3 years now. It recently has been helping alittle bit, but I think its b/c I incorporated alot of probiotics and omega 3. I do alternate between cortifoam and canasa every night too. I have alot of gas and that been going on for the last 6 months. That's never been a problem before that though! Should lialda be taken with food or not? My GI never said whether or not.... Thanks everyone!

Regular Member

Date Joined Jun 2008
Total Posts : 24
   Posted 6/22/2008 9:01 PM (GMT -6)   
I've been taking Lialda since Feb. I was on 4 pills per day (2 in AM/2 in PM) and it was working great. I always took with meals. After 3 months it just stopped working. My symptoms returned just like pre Lialda even though I hadn't changed my regimen. My GI said that this sometimes it just stops working. I stopped all meds for about 3-4 weeks and recently restarted again. First 1 pill/day and now 2 per day.

I too get a lot of gas but mostly at night. So, I think this is common. If it bothers you, talk to your dr.

Good luck.
Dx w/ UP in 2005; Dx with UC in 2008
Currently taking: Lialda and Mesalmine Enema (1x per day); Tricor for Cholesterol
Male; age 42; Located in Atlanta

Elite Member

Date Joined Apr 2004
Total Posts : 23551
   Posted 6/22/2008 9:03 PM (GMT -6)   
I'm not sure about Lialda but I know that with Asacol which is a similiar form of Lialda that it's best taken with food to prevent it from damaging your stomach. I was on Asacol for many years and always took it on an empty stomach. After years of doing this, I think my stomach decided to call it quits and I now have acid reflux and/or gastritis. I have to take Prilosec now and I truly believe it was due to taking Asacol without food. But if you're in doubt, you can always ask your pharmacist.
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Regular Member

Date Joined Mar 2008
Total Posts : 68
   Posted 6/22/2008 9:26 PM (GMT -6)   
I used to take 4 pills a day, but I'm down to 2 now. Anyways my GI's nurse said to take it 15 minutes before breakfast, so I take it on an empty stomach and then eat something after.

Regular Member

Date Joined Mar 2007
Total Posts : 125
   Posted 6/22/2008 11:16 PM (GMT -6)   
Thanks for the replies. Im gonna call my pharmacist tomorrow. The 15 mins before breakfast seems like a good idea though! Thanks again!

Veteran Member

Date Joined Apr 2006
Total Posts : 3402
   Posted 6/23/2008 1:04 PM (GMT -6)   
Unless a medication specifically states to be taken on an empty stomach - it is best to take all with food or you run the risk of developing gastritis.

Let us know what the pharmacist said :)
Pan-colitis and GERD diagnosed May 2003</U>[/color>


<FONT color=orange>Status: close to remission?!?!?

20mg Pred, Asacol 12 per day, Azathioprine 100mg, Aciphex, Forvia, and Pro-Bio

Co-Moderator for the UC forum:</A>

New Member

Date Joined Jul 2008
Total Posts : 2
   Posted 7/16/2008 12:42 AM (GMT -6)   
Lialda or Asacol had a "delayed-releas coating" which means they don't -and should NOT- dissolve in your stomech on small intestine. To achieve best results the tablets should stay intact until they reach the colon to releasing there substans.!! I take them on empty stomach all time never bothers me.

Regular Member

Date Joined Jul 2008
Total Posts : 24
   Posted 7/16/2008 6:02 AM (GMT -6)   
The instructions straight from the pharmaceutical company say the following (emphasis mine):

The recommended dosage for the induction of remission in adult patients with active, mild to moderate ulcerative colitis is two to four 1.2g tablets to be taken once daily with meal for a total daily dose of 2.4g or 4.8g. Treatment duration in controlled clinical trials was up to 8 weeks.

Left Sided Ulcerative Colitis diagnosed Jan 08
Minimal Change Disease diagnosed Feb 06

Regular Member

Date Joined Mar 2007
Total Posts : 125
   Posted 7/16/2008 9:41 AM (GMT -6)   
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