questions for those who have tried 6-MP/ mercaptopurine/ purinethol

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piper_chris
Regular Member


Date Joined Jun 2008
Total Posts : 73
   Posted 6/23/2008 9:37 PM (GMT -6)   
Hello,
 
I posted an intro about myself this morning in this thread if you're interested:
 
I have recently started 6-MP/ mercaptopurine/ purinethol and am curious to know:
 
What dose did you take or are you taking? 
 
I am told weight is a factor in determining the dosage amount.  If you don't mind saying so (optional), about how much did you weigh at the time?  I weigh about 120 pounds. 
 
How often did you get blood work checked at first?
 
Was your blood work normal? 
 
Did they check anything besides CBC (complete blood count) and CMP (comprehensive metabolic panel)?
 
My blood work after 2 weeks on 50 mg was abnormally low in several areas.  But instead of taking me off my doctor increased the 6-MP dose from 50mg to 75mg.  Hence some of my concerns/questions.  If it was the 6-MP causing CBC and CMP numbers to drop (hard to prove at this point if it truly was due to 6-MP) then I think the problems will increase with the increased dose.  My next blood work isn't until 3 weeks after the previous blood work so I'm biting my nails wondering stuff meanwhile.
 
Did you have any negative side effects that you were pretty sure were from the 6-MP?
 
If you stayed on 6-MP, how effective has it been and how long did it take to kick in?
 
If you got off the 6-MP, why did you?
 
Thank you!
 
 


- diagnosed ulcerative colitis Feb 2005
- currently 25mg prednisone (tapering down), 75 mg 6-MP/mercaptopurine/purinethol (just started), asacol/mesalamine 4800mg (4 pills x 3 times day), 1 Canasa 1000 nightly, VSL#3, multivitamin, calcium, fish oil, sometimes digestive enzymes

Post Edited (piper_chris) : 6/23/2008 8:42:15 PM (GMT-6)


Red_34
Elite Member


Date Joined Apr 2004
Total Posts : 23551
   Posted 6/23/2008 9:52 PM (GMT -6)   
What dose did you take or are you taking? Right now I am taking 100mgs of 6mp on Monday and Thursday and 50mgs for rest of the days.
 
I am told weight is a factor in determining the dosage amount.  If you don't mind saying so (optional), about how much did you weigh at the time? When I started I weighed around 115lbs.  I am now at 130lbs.  I think they base the initial dose on weight and then tweak it depending on how you are metabolizing it.
 
How often did you get blood work checked at first? I had to have my blood drawn weekly for about a month, then every 2 weeks for a month and then once a month.  I am now at every 3 months.
 
Was your blood work normal? My WBC dipped a little in the beginning but then it stabilized.  My numbers are good now.  But my GI was watching it pretty closely for a while.
 
Did they check anything besides CBC (complete blood count) and CMP (comprehensive metabolic panel)? I'm not sure if the CMP is the same as liver function but that is mainly what I get tested for, CBC and liver.
 
Did you have any negative side effects that you were pretty sure were from the 6-MP? The main side effects that I experienced were headaches, fatigue and slight nausea.  Nothing too major and once my body got used to the med, all the side effects stopped.
 
If you stayed on 6-MP, how effective has it been and how long did it take to kick in?  For me it took about 7 weeks before I noticed a slight difference but it took about 3 months for me to see the full result.  I have now been on 6mp for 1 1/2 years.  It has helped me tremendously.  I still flare but not as severe as before.
 @--->--SHERRY--<---@
Moderator for Allergies/Asthma and Co-moderator for UC
~Left sided Uc-'92-Colazal(9 daily),6mp(50-100mgs), Hydrocortisone E's, Prilosec,Biotin,Forvia,Pro-Bio**Unable to tolerate Asacol, Rowasa or Canasa**~Allergies-Singulair
~Secondary Reynauds Syndrome-'04-Norvasc~Spinal Stenosis~Sacroiliitis-epidural injections
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kelina
Regular Member


Date Joined Aug 2005
Total Posts : 322
   Posted 6/23/2008 10:13 PM (GMT -6)   
i've been on 6mp for about years, never had any side effects, get blood work done every two months, i started with 50 mgs, and went to 100 cause i stopped taking other meds, for uc i only get 6mp now and remicade every 8 weeks. everything has always been normal for me, thank god.

27 yr old, female lower left moderate to severe UC since 2002

Colazol 3 pills 2x per day, 6 MP 50 mgs per day

Flax Seed Oil 2 per day, VSL#3 4 pills per day, Food enzymes 2 b4 meals when needed

canasa when needed, can't do rowasa!

Next Remicade Treatment Jan 31st

 


Severin
Regular Member


Date Joined Oct 2007
Total Posts : 320
   Posted 6/23/2008 10:28 PM (GMT -6)   
* I have taken 100mg per day, am now on a combo of 25mg 6-MP and 100mg Allapurinol;

* I weigh 54kg, same as I did when I started the 6-MP;

* Blood checked every 3 days for the first fortnight, then every week for a month, then every fortnight for 6 months, now monthly;

* It was initially ok with 6-mp for 2.5 years, then my body started having difficulty handling the metabolites of 6-MP, that is why I am now on the above combo;

* I get the Australian equivalents of those two tests I believe, full blood count and metabolite check;

* It can take a while for your body to adjust to handling the 6-MP and usually those blood-work numbers will flatten out;

* Side effects at worst were massive weakness and lethargy once my body started having difficulty with the metabolites, initially just a little more tired then usual.
"We are dreamers, shapers, singers and makers..." - Elric, Technomage
  • 28yo male. Brisbane, Australia. Diagnosed at 16yo. Currently enjoying severe pan-colitis.
    - Participating in the Golimumab trial as of 1st May, 2008;
    - 2x Colazide, twice a day; 25mg of 6-MP a day; 1xAllopurnol;
    - 1x teaspoon of Metamucil 3 times a day;
    - 3x Garlic oil capsules & 7mL Olive Leaf Extract twice a day.

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