I was just recently diagnosed with UC back in April. At that time I was on cortifoam and asacaol. I started having irregular vaginal bleeding right away but chalked it up to the cortifoam since that is a side effect. I have now been off of the cortifoam for over a month and was switched to 2 Lialda daily and the bleeding has gotten heavier. I went to the GI yesterday and discussed it with her but at that point I hadn't bled in 3 days so she said just to call if I had this problem again but seemed to have no idea why this would be happening. Well, this afternoon I started up again so I guess Monday I will be giving her a call. Have you gotten any answers as to why you are having spotting?