I am pretty much in the same position as you except I don't have pancolitis.... Running out of med options and not sure if I have Crohn's or UC. When I first started wondering if I had Crohn's, I got very scared and nervous, mostly about getting surgery and also about possibly having Crohn's, period. I have never had that Prometheus test, I can't imagine what it would say but if my GI whom I have had for 8 years still isn't sure which I have, I wouldn't put too much trust on a blood test. Have you had an upper GI, SBFT or an endoscopy ever? I had an Upper GI, SBFT recently and when that came back with no Crohn's, it helped ease my mind a bit. (That barium practically killed me coming out, though!!) After those results I sat down with my GI and asked him what he really thought, he said that it is possible I have Crohn's in the rectum only, and in that case, it will only be known for certain if it's UC ir Crohns if/when my colon comes out. I am running out of options for meds and I am just hanging in there for now, hoping my ulcer doesn't preforate. I had a few meds work for a while but never long enough for some reason. I would consider Tysabri if this lovely Humira/6MP combo does not do the trick. I hope that you start feeling better and healing and that you can talk to your doctor about your concerns in more detail or get a second opinion.
Diagnosed with Left-sided UC in 1995 at age 15,
Prednisone, Rowasa & Hydrocort. Enemas, Proctofoam, Sulfasalazine, Asacol, Probiotics, Fish Oil, Aloe Juice, Canasa, Enotcort, Colazol, Anamantle, Remicade, etc... had 1 inch deep rectal ulcer 2004, put on Remicade, August 2007:Increased Remicade dosage-700mg every 6 weeks,diagnosed w/ Psoriatic Arthritis & Fibromyalgia Current meds: Clorazepate, Lomotil, Tylenol pm, Lyrica started 1/17/08, Humira started 4/4/08, 6MP started 6/24/08