ComedyDork - The mab set of drugs are all monoclonal antibody's used to inhibit the action of the pro-inflammatory signalling protein TNF-Alpha.
) was the first one to be approved for use by the FDA and was engineered as a chimeric TNF-Alpha inhibitor using both human and mouse protein sequences.
) came along after this and does the same thing, but it is constructed from a fully human monoclonal antibody. No mouse, and as such it causes fewer side effects and the chances of your body producing antibodies to it are much reduced.
And now there's Golimumab
. This drug is Centocor's answer to Humira. Humira was created by their competitor Abbott Labs. So Golimumab does about
the same thing again, is purely human but uses newer learning with regard to building artificial proteins to act on the body. My little brother does this stuff and he seems very impressed by the way it has been engineered. Hence why I am on this one.
And then there is Abatacept which is a completely different line of drug. It works by affecting the way the body signals T-Cells by interfering with the co-stimulation required to actually switch the T-Cell on, though my understanding of this drug is otherwise rather limited.
"We are dreamers, shapers, singers and makers..." - Elric, Technomage
- 28yo male. Brisbane, Australia. Diagnosed at 16yo. Currently enjoying severe pan-colitis.
- Participating in the Golimumab trial as of 1st May, 2008;
- 2x Colazide, twice a day; 25mg of 6-MP a day; 1xAllopurnol;
- 1x teaspoon of Metamucil 3 times a day;
- 3x Garlic oil capsules & 7mL Olive Leaf Extract twice a day.