For some they work better than others....I don't think you get immune to them, however, either they work or they don't.
The higher dosage of oral 5ASA can cause side effects such as diarrhea or exacerbation of symptoms such as bleeding...but worth a try. I wouldn't jump to 12 daily tho.
How are you taking them...twice daily or thrice?
If you do increase...add one per dosge for a week or two...then do the same again till you reach 12. You might then find that only one increase will get you to an improved state.
Regarding rectal meds...are there any hydrocortisone suppositories available if not any 5ASA? The enemas are the best, but the suppositories will help a lot.
*Heather*Status: mini flare Dec 28... tapered to every 4th night
~diagnosed January 1989 UC (proctosigmoiditis)
~5ASA: Asacol (6 daily) + Salofalk enemas (increase for flares tapered to maintenance)
~Bentylol (dicyclomine) 20mg as needed
~Probiotic 3(Natural Factors Protec) bedtime + 1 (Primadophilus Reuteri) occasionally
~multi-digestive enzymes as needed ....zymactive 3 - 5x daily
~Ranitidine,Pariet (reflux) Effexor XR 75mg; Pulmicort/Airomir (asthma)
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS" worth it !!!