After being on 6-MP for over three months with no remission my GI raised my dose to 75mg and ordered a Prometheus test. I am so thankful for all that I have learned from reading posts on this web site, because I asked for the Prometheus test when he wanted to raise the dose.
I do not like 6-MP because of the possible side effects and I don't want to be pregnant on it which puts off adding to our family. After starting 6-MP I started having trouble with mouth and nose sores. I have never been prone to mouth sores/ulcers before. I brought this up with my GI and he didn't think it was from the 6-MP. On the internet I read that mouth sores are usually associated with high doses of 6-MP. The mouth and nose sores were a red flag to me that I didn't think I was handling 6-MP well.
On the same day he raised my 6-MP we increased my Lialda to 4 per day. I saw great results with the Lialda and am so excited to be in remission now for a couple of weeks. I already scheduled an appointment with an IBD center (my GI referred me) at a research hospital prior to getting better. I decided to keep the appointment to go ahead and get established with a secondary doctor and to get a second opinion on meds. I want to get totally off the steriods and 6-MP and in my mind, live happily and in remission on Lialda. My Premetheus test indicated "Lower Likelihood of Response" based on a 6-TGN level of 127 with normal being 230-400. It also says "Higher Risk of Hepatotoxity" with a 6-MMPN level of 8102 with normal being <5700.
I know a lot of you are way more experienced than me on this stuff and some of you have said that you had to stop 6-MP based on Prometheus results. Does anyone know if these levels should indicate me stopping or just reducing 6-MP. I go to the other doctor on Monday and I want to be armed with as much info as possible. After receiving these results my current doctor wanted a CBC today so we'll have those results at the end of the week. Thank you for reading this and any input!
- 25 years old
- Ulcerative Colitis since Sept. 2004
- 1st flare Sept-Nov 2004
- 2nd flare Aug. 2007-present
- Currently taking
1000mg Dipentum, 75mg 6MP, and weaning off Entocort at 6mg, 4 Lialda, Digestive Advantage Chrons/Colitis, and Women's One a Day