Readers MOST effective drugs/treatments

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motoinkyoto
New Member


Date Joined Jul 2008
Total Posts : 4
   Posted 7/17/2008 9:05 AM (GMT -6)   
 
   Hi to all,
   I’m a newbie and if this has been covered before (and I dare say it has) my apologies….
   Anyhows, here’s my question to you all.
   I’ve been reading posts here for quite a while and there have been so many drugs mentioned
   that it’s hard to know which are effective.
   There is prednisone, azathioprine, asacol, pentasa, remicade, Lialda Colazal, Rowasa salazopyrin, Imuran. etc, etc, etc .
   Now I know that these drugs can be broken down to Sulfasalazine, 5-ASA, steroids and immunosuppressants and of course I understand that
   everyone is different, but I’m really interested to know which drugs and treatments readers here have found most effective.
   This would not only help new and old readers alike but is also of particular interest to me because many of the drugs I’ve read about are
   unavailable where I live and I wonder if some of the drugs used here might be of benefit to readers to this site or if they are just old and no
   longer used in the west.
   Whew, OK to cut to the chase I live in Japan and was diagnosed with (mild to moderate) left-sided UC in early 2007. First, I was put on Pentasa  
   enemas and later Pentasa tablets and this was very effective for around 6 months or so but gradually my symptoms worsened. I tried
   acupuncture and increased Pentasa doses but to no avail. Finally I was admitted into hospital with extremely severe UC. As in the west they
   tried steroids first Predonine (predisnolone) and I was given a new treatment with a type of dialysis called G-cap (where they removed the
   most harmful white cells from my blood) twice a week. Sadly, this too was ineffective.
   So, I switched hospital and was put on an IV drip and treated with Taclorimus which I was told was not popular in western countries.
   It was incredibly effective, in less than a week my bpms? (I still don’t know what this stands for!) Dropped from 14 times a day to four or
  five and within another 3 or 4 days I was down to two! I then moved from drip to taclorimus tablets and salazopyrin which is an older, less-used 
  drug but my doctor said if you don’t have the side effects it’s actually more effective than Pentasa as 100% goes into your colon whereas
  with Pentasa 40% is lost in the small intestine before it reaches the colon.
  After 2 months in hospital and losing 18 kilos I finally left January this year. Anyways, 6 months on I’m still on Taclorimus but am slowly
  switching to Imuran which is a more proven long-term immunosuppressant. My bpms are now down to 3-4 times a day.
  Wow, this post is far too long-Sorry!
  So, that's my story. Now I’d really like to hear from others about what drugs or treatments have most helped you and what you would most 
  recommend to others?

Red_34
Forum Moderator


Date Joined Apr 2004
Total Posts : 23551
   Posted 7/17/2008 9:22 AM (GMT -6)   
Hi, welcome to Healingwell :) We all respond differently to different treatments but the usual progression of Uc meds are as follows:

First line should be 5-ASA's - Asacol, Lialda, Pentasa, Colazal
The 5-ASA rectals meds are - Rowasa, Salofalk, and Canasa
Some docs prescribe steroids if the case is severe enough or they want to get the patient in remission faster - which I don't always agree with but sometimes it's necessary. There is of Prednisone, which you know is oral but there are also steroid enemas (Colocort) and steroid foam (Cortifoam).
If the patients fail these traditional meds, then immune suppressors are used such as Imuran or 6mp. And after that comes Remicade or Humira. Humira though is still in the beginning stages of trial to help Uc'ers and I'm not quite sure if that has been 100% approved here in the states. There is another heavy duty medication but for the life of me, I can't remember the name of it but it is issued intravenously thru the hospitals.

I myself have found that I am mostly unresponsive to most meds. I am on Colazal which helps partially, as well as 6mp - I found out recently that it is failing me and occasional usage of Colocort steroid enemas. Right now, I am *crossing fingers* in a tentative remission.


 @--->--SHERRY--<---@
Moderator for Allergies/Asthma and Co-moderator for UC
~Left sided Uc-'92-Colazal(9 daily),6mp(50-100mgs), Hydrocortisone E's, Prilosec,Biotin,Forvia,Pro-Bio**Unable to tolerate Asacol, Rowasa or Canasa**~Year-round allergies-Singulair, Allegra
~Secondary Reynauds Syndrome-'04-Norvasc~Spinal Stenosis~Sacroiliitis-epidural injections~bulging and herniated discs C5,C6&C7~2nd epidural injection 8/14
To help Healingwell - click here: DONATE
 
 
 
 

 
 


princesscolon
Veteran Member


Date Joined Apr 2006
Total Posts : 733
   Posted 7/17/2008 2:56 PM (GMT -6)   

Hi there,

  The abbreviation is bms and means bowel movements. :) Bpm I think means beats per minute as in heart rate.  Everyone here will tell you the drug that works/worked for them but it definitely does not mean it will work the same for you since that is how it is with this disease, unfortunately.  When I was first diagnosed, Sulfasalazine pills worked fairly well for me but eventually stopped working.  Then I had some luck with Rowasa enemas.  Then later Asacol seemed to help for a while.  Next, Remicade was the drug that brought me into my only short-lived remission but it lost its effectiveness, I got a higher dose and had a reaction.  Now I am on Humira and 6MP and I am not impressed so far.  I have tried everything else medicine wise in between but either saw no results or had some sort of reaction such as severe migraines or shakiness.  How long have you been on Imuran?  Keep in mind it could take around 3+ months to see any change on Imuran.  If you are going to contine the Imuran, I would consider adding a rectal medication such as Rowasa enemas or Proctofoam.  Could you make a signature which makes a description of what meds your on and to what extent your UC is please?  I hope the Imuran works for you and I hope I don't scare you with my experience, I am an oddity so don't worry too much.

PS- I think the med Sherry was referring to is either Tysabri or Cimzia...

Diagnosed with Left-sided UC in 1995 at age 15, Prednisone, Rowasa & Hydrocort. Enemas, Proctofoam, Sulfasalazine, Asacol, Probiotics, Fish Oil, Aloe Juice, Canasa, Enotcort, Colazol, Anamantle, Remicade, etc... had 1 inch deep rectal ulcer 2004, put on Remicade, August 2007:Increased Remicade dosage-700mg every 6 weeks,diagnosed w/ Psoriatic Arthritis & Fibromyalgia Current meds: Clorazepate, Lomotil,  Tylenol pm, Lyrica started 1/17/08,  Humira started 4/4/08, 6MP started 6/24/08

Post Edited (princesscolon) : 7/17/2008 2:59:00 PM (GMT-6)


motoinkyoto
New Member


Date Joined Jul 2008
Total Posts : 4
   Posted 7/18/2008 5:35 AM (GMT -6)   
 
Princess colon,  red_34 Thanks a lot for the input and information.
Sorry for the delay, (time difference, work)
There is such a bewildering array of drugs available for UC and many of them just seem to be variations of other established drugs,
so it's really helpful to get some kind of feedback on there success or failure.
Many of these drugs mentioned on these forums are not available here in Japan for a variety of reasons and conversely treatments
available here don't seem to be used in the west. From my own experience I would have to give taclorimus a ringing endorsement as
an short-term immunosuppressant. (actually I've been on it for 6 months and am slowly tapering off)
Also,I have not heard any mention of Granulocyte and monocyte adsorption apheresis (GCAP) dialysis as a form of treatment for UC.
It seems to have had success with other types of auto-immune disorders like athritus and I was hoping to get feedback on what other
people thought or have experienced.
Anyways, thanks so much for the replies.
 
 
 
 

Diagnosed Left-sided UC in early 2007
Hospitalized 2007/8
Former Medications: Pentasa
Now: Taclorimus 8mgs,  Salazopyrin 4 mgs Imuran 75mg daily
 

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