Hello. I've had U.C. for about 4 yrs now. All of the normal meds(colozal, asacol, and now lialda), seem to make my symptoms worse. The only thing that has ever worked for me is Azathioprine(imuran) at 50 mg, and a maintenance low dose of prednisone where I take 10 mg per day. Even with this, I still have problems in the middle of the night and the morning, but the 50 mg imuran and 10mg pred with breakfast gets me through the whole day 99% of the time without a problem. My concern though is what preds and Imuran might do to me long term. My doc thinks I should not really take either medication long term. I do the blood tests, which so far have come back fine every time. I don't want to be doing long term damage to my health, but...it took me forever to find a combination that gets me through the day...and it's so frustrating that the normal medications just don't work. If I go off preds, the symptoms come back within a week, even when i tired to up the dosage of Imuran to 100mg. It seems i'm stuck right now with low dose prednisone. No crazy side effects yet, but I'm worried about my future health. Just thought i'd get some thoughts from others that might have had some similar issues. Thanks for any responses.