I have been trying to taper off of Prednisone for awhile now. I have been on it for a year and luckily i have not had any side effects that can come with it. Other then the fact that it is bad for your body in general i wish i could stay on it because it keeps my UC under control. However since its not good to be on a long time i have been tapering and having a hard time getting off of it. This is my 4th taper and now they are trying to use Entocort with it to see if that helps any. So far i am down to 15mg of Pred and doing ok. Prednisone affects everyone differently (as you have seen in your own family).