UC parents to UC children??

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aneerby
New Member


Date Joined Jul 2008
Total Posts : 15
   Posted 7/24/2008 5:40 PM (GMT -6)   
Hi. I am recently diagnosed with UC. My brother has UC, as does my husband's cousin and his grandmother has Crohns. I researched and found that UC is hereditary to some degree. I wondered if anyone out there who has had the disease for awhile has children with the same problem? We really want to have a family....

kb5
Veteran Member


Date Joined Jan 2007
Total Posts : 1015
   Posted 7/24/2008 6:20 PM (GMT -6)   
The chances of passing UC down to your kids is under 10% unless your husband also has IBD then it jumps to 25%

This does keep many from having kids but just as many maybe more have kids.

My thinking is that my kids have a chance of inheriting this...or breast cancer from my mom's side, high cholesterol, high blood pressure, and the family nose. Not to make light but i feel that the chance is low. And even if they do get UC who better to be there and understand than a mom who has been there.

I am pretty sure there are parents with uc who have kids with uc and many who don't have uc but there kids do. hopefully they will chime in too

My husband and I are going to start trying next fall for our first.

Good luck!
Kelly, 30

Left sided UC diagnosed 1/98 age 19, Pan colitis diagnosed 1/07
Currently on 4x3 Asacol, no more pred after two years!!!! Off imuran as remicade is working!
Prontonix once daily for acid reflux, zofran 8mg every six hours for nausea
Remicade started 3/1/08...just had 4th infusion


suebear
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Date Joined Feb 2006
Total Posts : 5698
   Posted 7/24/2008 6:46 PM (GMT -6)   

And if your children were to inherit UC, the breast cancer gene, or other heriditary problem the chances of newer treatments or cures might be there by the time they are faced with a diagnosis.

Sue


dx proctitis in 1987
dx UC in 1991, was stable until 1998

1998 started prednisone, asacol, pentasa, nortriptylene, ativan, 6MP, rowasa enemas and suppositories, hydrocortisone enemas, tried the SCD diet, being a vegetarian, omega 3s, flax, pranic healing, yoga, acupuncture, probiotics

2000 lost all my B-12 stores and became anemic

2001 opted for j-pouch surgery- now living life med-free


aneerby
New Member


Date Joined Jul 2008
Total Posts : 15
   Posted 7/24/2008 6:51 PM (GMT -6)   
very good points. thanks for the replies :)

26,
Diagnosed with UC June 2008. On Asacol...many questions still unanswered


lemonhead
Veteran Member


Date Joined Dec 2007
Total Posts : 1028
   Posted 7/24/2008 7:10 PM (GMT -6)   
I don't know if it is true, but I hear it skips a generation, and I heard......just published in CCFA newsletter that inheriting it from one parent is under 5%. Didn't stop us from having kids, but it does make us more aware of their health.
diagnosed with left-sided UC in 1997. (45cm)
Currently on 10mg Prednisone
12 caps of colazal    9 caps Colazal
2 rowasa enemas nightly
35, female


Bennie
Veteran Member


Date Joined Nov 2006
Total Posts : 552
   Posted 7/24/2008 7:19 PM (GMT -6)   

I do not have an IBD but I am the mother of a daughter who has/had UC (she just had surgery on July 3). And her older brother was diagnosed with Crohns this past spring. These diseases come down through my side of the family although I didn't realize it until after my daughter was diagnosed. I remember that my aunt (my mother's sister) had stomach issues. My mom always said that she was sickly as a young girl and had "colitis and ileitis" (basically Crohns). Unfortunately they both passed away so the only one I can get any information from is my cousin (and we really don't speak much). And it has never been a big issue for me to find out what my aunt did many, many years ago when there have been so many advances since then.

Anyway, even though I know I technically "gave" my children IBD, it wouldn't change my mind about having them (nor my husband's mind). And this is even including having to help make the decision to watch our child go through major, life-changing surgery. We pass many genes on to our children--some good, some bad. Advances are being made everyday (maybe not fast enough for the current IBD patients). Personally, we did not play the what if game. What if we pass on the cancer gene, the asthma gene, etc. On the other side, what if we do pass on the intellect gene, the artistic gene, etc. and our children are part of finding a solution?

Good luck with your choices.


--Mom of bratcat (17 years old)--
Daughter bratcat was diagnosed with pancolitis October 2006
Current meds:
Asacol - 4 pills/3Xday, 15 mg prednisone, Remicade
 
11/14/06 - started prednisone; 1/28/07 - finished prednisone!
3/3/07 - began to taper off hydrocortisone sloowwly! Summer 2007 - slowly began tapering Rowasa. 9/07 -- flaring? Nightly Rowasa. 9/21/07 -- added hydrocortisone enemas. 9/30/07--added prednisone. 10/31--started 6-mp, stopped the enemas. Started lowering prednisone. 3/08-another flare!  7/3/08-Step 1 j-pouch surgery


JewelsOK
Regular Member


Date Joined Jun 2007
Total Posts : 364
   Posted 7/24/2008 8:35 PM (GMT -6)   
I wish I knew where it came from. I have a very large family on my mom's side and my husbands family is rather large. No one in either of our back grounds have IBD. Yet we have two kiddos with it and my husband's sister has one child with it.
Julie

Mom of Son 16 UC dx 07/02, Sulfasalazine, Imuran, folic acid, L. Reuteri, Zyrtec, Iron, Vit/Min

Daughter 9 UC dx 08/07 Colazal, 6MP, Iron, Vit/Min., Culturelle


UCfree_at17
Regular Member


Date Joined May 2008
Total Posts : 91
   Posted 7/24/2008 8:50 PM (GMT -6)   
Hey!
  Im Katrina, just turned 17 on July 21st :-)  I was diagnosed with severe UC about 4 months ago. My dad has always had stomach problems but hes a "tough guy" and hates going to the doctor so he just dealt with pooing everytime he ate. The way he dealt with it was by not eating but maybe once or twice a day. My junior year of high school I started having problems. I dont remember how it was when I first started having problems. It was about a year ago. I went undiagnosed because of retarded doctors for about 10 months. I found out I had UC through my entire colon via colonscopy. Im sure I got this from my dad and Im almost positive he has the same thing. He just refuses to go to the doctor. My mom has IBS and Im not sure if I have it too but do you think when Im ready to start a family the chances of my child(ren) getting either/or is high or low?
 Thanks and good luck with everything.

pb4
Elite Member


Date Joined Feb 2004
Total Posts : 20577
   Posted 7/24/2008 9:24 PM (GMT -6)   
The actual statisitic according to Dr. Kevin Riuox (a researcher specializing in genetics/hereditary factors of IBD) if one parent has IBD (either crohn's or UC) there is a 10- to15- fold increased risk their offspring will develop IBD as well compared with those who do not have a parent with IBD.

My mom has UC and I have crohn's, I'm the baby of six kids and the only one with IBD so far...my mom was in her mid 60's when she got sick I was in my early 20's so technically I got sick before she did, there's just no telling if any of my other (older) siblings might still not get an IBD as well since it is also a matter of one's IBD being triggered as well as being genetically predisposed to getting it.

Like with any illness, there are no guarantees, it's the chance you take...I don't really no anyone that doesn't have some kind of health issues, be it bad eyes or even bad teeth.

:)
My bum is broken....there's a big crack down the middle of it!  LOL  :)


GangGreen
Regular Member


Date Joined Apr 2008
Total Posts : 44
   Posted 7/24/2008 11:52 PM (GMT -6)   
Does anyone know the percentage on passing it down if just the father has UC but not the mother?  Also, does the percentage change depending on the severity of the case? (mild vs. severe UC)

dx UC Dec. 2001
currently in remission
 
Meds: asacol 6(400mg)/day
         entocort 3(3mg)/day
         canasa 1(1000mg)/day
         Culturelle 1/day
 


pb4
Elite Member


Date Joined Feb 2004
Total Posts : 20577
   Posted 7/25/2008 12:49 AM (GMT -6)   
The percentage stays the same, as quoted by Dr. Rioux, if one "parent" (either mom or dad) has IBD then...

The percentage does not change according to the severity...the severity is actually dictated by a new discovery of at least 9 different gene clusters that contribute to the development of IBD and defines the severity and behavior of the disease over time which varies from patient to patient and so far there is nothing indicating any connection to the severity of a parent compared to that of their offspring.

:)
My bum is broken....there's a big crack down the middle of it!  LOL  :)


tums
Regular Member


Date Joined Apr 2008
Total Posts : 128
   Posted 7/25/2008 4:05 AM (GMT -6)   
My gran has UC diagnosed in her 40's (she's now 86). My dad and aunt are fine so it skipped a generation but hit me and my brother (both diagnosed in mid 20's).

32 year old female
UC diagnosed 2001
Asacol 6 per day
Azathioprine 100mg started 4/08
Steroids 5mg per day


rocal
Regular Member


Date Joined Jul 2008
Total Posts : 41
   Posted 7/25/2008 8:20 AM (GMT -6)   
My 2yr old son was just Dx with UC I can find anyone in either side of his father's or mine that had any kind of issues such as this. Like everyone has said before it's a risk like passing on diabeties, cancer etc you can't predict what happens. For a while in the beginning I would wonder what I did during my pregnancy was it because I missed some of my vitamins, I drank coffee etc but I realized I did that all with my daughter and she is very gifted and talented so things happen we have no control over. Children are a blessing and everything I've gone through with my son I wouldn't change for anything he's taught me a few things and his smile and his laugh are why I get up everyday( should I say both my kids). The other writers are right you understanding UC you are the perfect parent to know the signs and symptoms. I had no idea what was happening to my son I fought with his first Ped and finally got a new Ped who got us on the right track. I've learned alot from this forum and others. If you truely want children I wouldn't hesitate they are truely a blessing. 

 Robin mother of 2yr old son diagnosed in Apr this yr with UC
 He's only on Culterella as of now


kb5
Veteran Member


Date Joined Jan 2007
Total Posts : 1015
   Posted 7/25/2008 8:30 AM (GMT -6)   
I have a genetic question...

Is there a genetic link between IBD and IBS? Both of my parents have IBS as well as a few other family memebers but none have IBD. Could there be a genetic link?
Kelly, 30

Left sided UC diagnosed 1/98 age 19, Pan colitis diagnosed 1/07
Currently on 4x3 Asacol, no more pred after two years!!!! Off imuran as remicade is working!
Prontonix once daily for acid reflux, zofran 8mg every six hours for nausea
Remicade started 3/1/08...just had 4th infusion


rocal
Regular Member


Date Joined Jul 2008
Total Posts : 41
   Posted 7/25/2008 8:43 AM (GMT -6)   
I don't know about genetics but all the books I've read and research IBS has no clear inflammation of the intestinal system and they say is brought on by stress, emotional issues they treat the moility of the intestinal track. IBD shows inflammation and and that's how the 2 are separated. The books and research  say the 2 have nothing to do with each other. IBS is sometimes caused by pain receptors from the intestine to the brain, they said IBS is treated with anti anxiety's and anti spasmatics. I hope this makes sense

 Robin mother of 2yr old son diagnosed in Apr this yr with UC
 He's only on Culterella as of now


PeanutMom
Regular Member


Date Joined Jun 2008
Total Posts : 197
   Posted 7/25/2008 9:51 AM (GMT -6)   
I knew I had UC and we had a baby. He's 18 nearly 19 months and healthy as a horse. . . .seems almost as big as one too LOL Well ok not that big but he is on the taller side for his age. To this point in time he's regular as clock work and other than interrupting play time to grunt as he goes he has no problems with his bowels. In fact to date he's only ever had loose bowels was once when he drank too much apple juice one day (Mommy, Daddy and nana all gave him some with out anyone checking with the other person .. .woopsie) and the other time he had loose bowels there was a stomach bug going around that everyone got. Other than that he's normal and never gets constipated either.

As far as IBS/IBD /anything historical in my family. . . .we're stumped, I'm the first with Kidney issues (of this type, grand father had tumors, they say it's completely different and no connection), I'm the first with UC or any digestive issues . . .my family prides itself on their "iron guts" because they can eat anything and not have trouble . . . I do envy them that, and I'm the first with Low BP and low sugar. They often joke that I look so much like both parents just to confirm I am not the milkman or mail man's kid! (o:

I wouldn't change a thing he's the best thing that could have happened in our life, I personally say if you are at a stage where you can carry the pregnancy without causing yourself bodily harm and that's something you really want. . .do it and then cherish every single minute because it goes by way too fast but it's a great trip!
Kim
~ Mom of Nathaniel aka "Peanut" 18m (6/08)~ Married ~ 36
"The List "
- UC dx 8/2000 - Culturelle 1x day Prenatal Vitamin (Currently not flaring but not what I would call in remission either.)
- CKD Stage 3 (Chronic Kidney Disease) - Lisinopril 7.5mg - Still have 27% function!
- Anemic - Ferolicit IV on hold (6 weeks free of IV, check in August)
- Allergies - Zyrtec 10mg 


pb4
Elite Member


Date Joined Feb 2004
Total Posts : 20577
   Posted 7/25/2008 11:42 AM (GMT -6)   
I don't think researchers have discovered any genes linked to IBS (but I'm not sure, I've never googled IBS and genetics) and although many of us have both IBD and IBS, IBS is considered a disfunctional disorder unlike IBD which is an actual inflammatory disease so although the symptoms can greatly mimic one another they are definitely 2 completely different entities...

Like I mentioned before, my mom and I so far, are the only ones that are dealing with IBD, I have IBS as well which I only developed about 4ish yrs ago now and none of my other siblings have IBD but my oldest sister was DX with IBS about 2 yrs ago...there is no evidence either that IBS leads into IBD but some docs believe that IBD can bring on IBS for the obvious reason that with all the inflammation issues IBDers have it seems fair to consider the bowels will become irritable (hence the name irritable bowel syndrom) there is a huge gut-brain connection with both as well.

:)
My bum is broken....there's a big crack down the middle of it!  LOL  :)


Eva Lou
Veteran Member


Date Joined Sep 2006
Total Posts : 3442
   Posted 7/25/2008 12:01 PM (GMT -6)   

My UC started up, & I was diagnosed, shortly after my daughter was born. Even if I knew prior to having her, I'd have still gotten pregnant. I watch her bm's like a hawk! Every time she has any sort of tummy bug, or loose stools, I'm in there inspecting the toilet. But so far she is 100% healthy. We don't have any IBD in my family, but my father's side of the family has tons of auto-immune disorders. I myself have been diagnosed with 2 other auto-immune disroders aside from UC. So hopefully, that 5% chance of passing it on won't apply to us. Her dad is super healthy, so I'm hoping his fabulous genes will kick my weak defective genes to the curb!


diagnosed with UC '02
meds-
Asacol- 8 tabs/day
Remicade-10mgs/kg- since 4/07
Imuran- 150mgs/day
Culturelle
Fiber supplement
 
 
 


jars05
Regular Member


Date Joined May 2003
Total Posts : 297
   Posted 7/25/2008 9:26 PM (GMT -6)   
My mother lost her colon to UC about five years ago. I'm the only one of her four children to inherit such a cross. I have a baby girl 6 mo. old and I pray every night for her to not have inherited my "gut" genes. I don't worry about it though, because she'll make it like I did, if she gets it.
Age: 30
Sex: Yes please!
Location: Missouri
Diagnosed with UC in 1997.
Medications: 100 mg Azathioprine a day, Blech 40mg Prednisone
Supplements: calcium, and multivitamin
No. of colonoscopies: 5
Last scope: 6/7/08-everything looked ok.
 
 


quincy
Elite Member


Date Joined May 2003
Total Posts : 30993
   Posted 7/26/2008 1:58 AM (GMT -6)   
Don't believe the stats, for they cannot guarantee you anything.
 
Ever notice we want something more when we perceive we shouldn't or can't have it.

Anyone can justify the decisions they make whether they're the best ones or not.

From my perspective, what does it matter...the healthcare system (no matter where we live) is already screwed and breaking at the seams. If you can afford the insurance and the high cost of medications for yourself AND your possibly IBD (and whatever else goes with it) children...go for broke. If you can't...then don't have children.
But then many who have IBD don't get diagnosed until they're adults....so hopefully they can afford the treatments....and yes, maybe there will be better treatments and possibly a cure.

Most people are stressed beyond their abilities to cope in today's world....there are no guarantees and having "normal" children is pretty much a gamble as is having them grow up well-adjusted, unselfish and productive.

We all risk something.....we all have the right to procreate. Not that all should. We could all be dead tomorrow.
I would hope it would be a decision rather than impulse.
The love for a child will probably overshadow most doubt or guilt.
Anyone can live without a colon.... 

quincy


*Heather*Status: mini flare Dec 28... tapered to every 4th night
~diagnosed January 1989 UC (proctosigmoiditis)
~5ASA: Asacol (6 daily) + Salofalk enemas (increase for flares tapered to maintenance)
~Bentylol (dicyclomine) 20mg as needed
~vitamins/minerals/supplements 
~Probiotic 3(Natural Factors Protec) bedtime + 1 (Primadophilus Reuteri) occasionally
~multi-digestive enzymes as needed ....zymactive 3 - 5x daily
~Ranitidine,Pariet (reflux) Effexor XR 75mg;  Pulmicort/Airomir (asthma)
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS"  worth it !!!

Post Edited (quincy) : 7/26/2008 1:04:14 AM (GMT-6)

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