I am in a clinical trial for Humira (since it isn't yet approved for UC). It is a double blind study, so no one knows for sure who is getting the medication, at least for the first twelve weeks in some cases. I responded within the first week and haven't had blood since. I am now at week 14 and still doing well. I am currently tapering off of pred, and have had some issues with that, but nothing major.
I am also on Asacol and I don't think there is any intention of them taking me off of that one, so as soon as I am done with the pred, I will be down to the injections (which are bi-weekly) and the asacol. Definitely manageable.
My GI also told me that there are fewer side effects from Humira than Remicade-he thinks it is a "better" drug. So far, I am reponding well, and they have said that everyone else in the trial has been as well. There was one exception, but at the 12 week mark, they switched him to the open label study (to make sure he was actually getting the med) and since then, he has also responded well. I believe there are 8 of us currently involved in my local study group.
Oh, and I have been told the injections, which like I said are bi-weekly, will remain bi-weekly for the long haul.