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New Member

Date Joined Jul 2008
Total Posts : 2
   Posted 7/29/2008 4:04 AM (GMT -6)   
sad  Hi people,
Am off to see the Doc today have to start on azathioprine (gulp), can any body give me any inside information. I have read lots of stuff but what's it really like? Apparently it could transform my life ( i hope so) am feeling ruff.

Bum Deal
Regular Member

Date Joined Jan 2008
Total Posts : 34
   Posted 7/29/2008 4:54 AM (GMT -6)   
Hi lavendula,

Like any drugs, Azathioprine and Mercaptopurine have their benefits and side-effects - and I admit that the side-effects for Aza and Mercap sound pretty scary - I wasn't too keen myself when it was first suggested I try it. I can honestly say that Mercaptopurine is the drug that has made me feel the most well since I was diagnosed with UC. I was put on Pred at first but just couldn't get off the stuff - every time I even got near a low dose I would flare horribly again.
The doc tried me on Azathioprine at first, and although it worked really well to start with, it turned out I was allergic to it, so I was switched to Mercaptopurine (which is a different version of the same stuff). Since then I've been doing really well, and am very close to getting off the steroids (fingers crossed).
You can get fatigue and nausea with these drugs, but it varies from person to person. i had both with Aza, but none so far with Mercaptopurine (and the effects I had from Aza might have been due to me being allergic).
I'm not fully in remission yet, but my dosage is still being adjusted up to the right level - I would definitely say the drug has made a massive difference to me, as I can for the most part live a normal life at the moment.
It's definitely worth a try, even though it's a bit daunting. Good luck, and feel better soon.

Male 30 Years Old.

Diagnosed Pancolitis June 2007

Currently 10mg Prednisolone, 9 tablets Asacol, 50mg Imuran (started Dec 07), 100mg Mercaptopurine (following allergic reaction to Imuran)

Regular Member

Date Joined Jul 2008
Total Posts : 39
   Posted 7/29/2008 5:26 AM (GMT -6)   
hey, ive been on aza for about 10 weeks still getting to the right dosage, my doc told me before i started them if your body cant handle them you will know pretty much s8 away, cant really say much more cuz im pretty new 2 them myself and have nt got to right amont yet, but no side affects for me so far. Good Luck.

Regular Member

Date Joined Apr 2007
Total Posts : 385
   Posted 7/29/2008 9:25 AM (GMT -6)   

Our son was put on 6MP when he was first diagnosed and it really helped him. It did take him a long time to get off the Pred (had to do it 2.5 mg at a time), but he did get off it after about nine months.

He now has anklosing spondylitis and is on Humira, so he's in the process of getting off the 6MP now. We've got our fingers crossed that it goes well.

Breast Cancer at 37; bilateral mastectomy with reconstruction.
Colon resection 2004; Sub-Total colectomy September 2007 for colonic inertia - didn't work.
Son with UC; taking Asacol and 6MP with Prednisone and Rowasa added during flareups. Recently diagnosed with ankylosing spondylitis - now on Humira.
Husband with ankylosing spondylitis and psoriatic arthritis.

New Member

Date Joined Jul 2008
Total Posts : 2
   Posted 7/29/2008 1:09 PM (GMT -6)   
Hi rumble tums,

Thanks for your info it has made me feel better about giving it a go,feelin much more optimistic now. I just discovered this site today and am amazed at the amount of people. I've never met anyone with UC before, so to be able to chat about stuff and know that you get it is fab.

Keep healthy
Thanks lots

Veteran Member

Date Joined Dec 2005
Total Posts : 3238
   Posted 7/29/2008 1:13 PM (GMT -6)   
I've been on Aza for over 2 years now. It got me off pred but it did take several months to kick in. I take my dosage at night b/c I do have some nausea if I take it earlier in the day. I tend to get sick more often since I started aza. But I don't know if I can play that on the aza or my preschooler!
Tabitha (Tab)

100mg Azathioprine, 2 Fibercon, Colazal-9 a day, Acidopholis Pearls, Zegerid (not sure if it is working)
Co-Moderator UC Forum

Regular Member

Date Joined May 2007
Total Posts : 169
   Posted 7/29/2008 2:33 PM (GMT -6)   
I've been on it for a little over a year now. It took a while to kick in, and a while to get off the pred. due to insufficient dosage, but I think we've gotten things figured out (200 mg) and I'm doing well.
UC diagnosed Dec. 2006
Azathioprine 200mg/day
Multivitamin, fish oil, fiber supplement, Nature's Way Primadophilus Optima, Digestive Advantage Crohn's & Colitis

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