Asacol and Lialda are both Mesalamine. The difference is that Lialda is time-release and can be taken less frequently. Colazal is a different drug, Balsalazide. It is sometimes effective for those of us who cannot take or don't respond to Mesalamine. Sulfasalazine/Azulfadine is an older drug, one of the original ones used to treat UC. It is very effective for many people, but there are also a lot who have allergic reactions to it.
As far as which is best, that is an individual thing. Some of us with left-sided UC do best on Asacol or Lialda, some on Colazal and some on Sulfasalazine. The only way to know what works best for you is to try them.
If you're having pain and passing mucus, you're not in a complete remission. You should talk to your GI, and one of the things to discuss is rectal medications; Mesalamin and steroids are both available in enema and suppository form. Usually the last part of the colon to heal is the rectal area, and these options would deliver medication directly to that part of the colon.
Moderate to severe left-sided UC (21 cm) diagnosed 2001.
Avascular necrosis in both shoulders is my "forever" gift from Entocort.
Colazal, Remicade, Nature's Way Primadophilus Reuteri. In remission since April, 2006.
Co-Moderator UC Forum
Please remember to consult your health care provider when making health-related decisions.