Can't Tolerate 5-ASA Oral Medications but ok with Rowasa?

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nsg121
Regular Member


Date Joined Dec 2006
Total Posts : 31
   Posted 8/10/2008 3:25 PM (GMT -6)   
Hi All,
 
   I just wanted to know if there's anyone on this forum who can't tolerate the oral 5-ASA's such as Colazal, Pentasa, Dipentum but rather can take and benefit from Rowasa enema's?
 
Thanks,
 
Nsg

Indeterminate IBD - 2003

Medications:  6-MP 25mg


quincy
Elite Member


Date Joined May 2003
Total Posts : 30587
   Posted 8/10/2008 10:14 PM (GMT -6)   
It would seem odd if an intolerance of 5ASA meds were only oral and not rectal. It's possible if one were having symptoms of oral 5ASA, the dosage might be too high or too low.

Symptoms....what were you having with te 5ASA meds?

Have you tried the suppositories?

Have you tried the enemas in the past?

q
*Heather*Status: mini flare Dec 28... tapered to every 4th night
~diagnosed January 1989 UC (proctosigmoiditis)
~5ASA: Asacol (6 daily) + Salofalk enemas (increase for flares tapered to maintenance)
~Bentylol (dicyclomine) 20mg as needed
~vitamins/minerals/supplements 
~Probiotic 3(Natural Factors Protec) bedtime + 1 (Primadophilus Reuteri) occasionally
~multi-digestive enzymes as needed ....zymactive 3 - 5x daily
~Ranitidine,Pariet (reflux) Effexor XR 75mg;  Pulmicort/Airomir (asthma)
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS"  worth it !!!


nsg121
Regular Member


Date Joined Dec 2006
Total Posts : 31
   Posted 8/11/2008 5:09 AM (GMT -6)   

Quincy,

   I took the 5-ASA drugs about 4 years ago and they caused me severe watery diarrhea and probably made my UC worse than it was.  My doctor now wants to try Rowasa, thinking that it might not affect me the same way.  Just wanted to know if anyone else was in a similar situation? 

~Nsg


Indeterminate IBD - 2003

Medications:  6-MP 25mg


Red_34
Forum Moderator


Date Joined Apr 2004
Total Posts : 23551
   Posted 8/11/2008 5:46 AM (GMT -6)   
In the beginning of my intolerance, I was unable to handle the oral mesalamines but did fairly well on the rectal. Then over time, I developed a true intolerance of all meslamines - oral and rectal. What symptoms are you having at the moment?
 @--->--SHERRY--<---@
Moderator for Allergies/Asthma and Co-moderator for UC
~Left sided Uc-'92-Colazal(9 daily),6mp(50-100mgs),Prilosec,Biotin,Forvia,Pro-Bio**Unable to tolerate Asacol, Rowasa or Canasa**~Year-round allergies-Singulair, Allegra~Secondary Reynauds Syndrome-'04-Norvasc~Spinal Stenosis(?)~Sacroiliitis-epidural injections~bulging and herniated discs C5/C6 & C6/C7~2nd epidural injection 8/14, Neurontin and Skelaxin
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damo123
Veteran Member


Date Joined Jul 2007
Total Posts : 714
   Posted 8/11/2008 6:34 AM (GMT -6)   
Oral 5ASA give me a host of stomach issues because of their aspirin-nature. Whilst the drug is not broken down in the tummy there is a reaction relating to the aspirin-like make-up of the drug on the stomach's lining. (It's actually to do with the ingredients of the 5ASA's preventing the breakdown of the drug in the tummy)

I'm fine with rectal 5ASA's as they do not contact my stomach!

D
Med free for a bit as I needed a break from Asacol
 
Probiotics
 
"Whatever you do in life don't berate yourself too much nor contragulate yourself too much. Your choices are half chance. So are everybody elses'"
 
 
 
 
 
 
 


nsg121
Regular Member


Date Joined Dec 2006
Total Posts : 31
   Posted 8/11/2008 7:39 AM (GMT -6)   
Red,
 
   I am having a flare up again of my symtoms, the usual blood, mucus, going to the bathroom about 6 - 8 times a day, urgency.  Doctor wants to try something else in order put it into remission, looks like I should give Rowasa a try.
 
Thanks,
 
Nsg

Indeterminate IBD - 2003

Medications:  6-MP 25mg


quincy
Elite Member


Date Joined May 2003
Total Posts : 30587
   Posted 8/11/2008 12:37 PM (GMT -6)   
Definitely try them. I would suggest you try the 2g initially.  Less med, but in a liquid that will reach/treat the sigmoid as well.
 
q


*Heather*Status: mini flare Dec 28... tapered to every 4th night
~diagnosed January 1989 UC (proctosigmoiditis)
~5ASA: Asacol (6 daily) + Salofalk enemas (increase for flares tapered to maintenance)
~Bentylol (dicyclomine) 20mg as needed
~vitamins/minerals/supplements 
~Probiotic 3(Natural Factors Protec) bedtime + 1 (Primadophilus Reuteri) occasionally
~multi-digestive enzymes as needed ....zymactive 3 - 5x daily
~Ranitidine,Pariet (reflux) Effexor XR 75mg;  Pulmicort/Airomir (asthma)
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS"  worth it !!!

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