My histology Results are back

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Veteran Member

Date Joined Oct 2007
Total Posts : 1198
   Posted 8/15/2008 12:00 PM (GMT -6)   
How am I to read into this?

Histopathology Report – Cromwell Hospital London


Specimens Received:


Rectal Biopsy                                - Active Chronic Inflammation

Rectal Biopsy                                - Active Chronic Inflammation

Sigmoid Biopsy                              - Normal

Transverse Colonic Biopsy            - Normal

Right Side Colonic Biopsy              - Active Chronic Inflammation

Ileum small bowel Biopsy             - Normal


No evidence Malignancy

No Evidence of Dysplasia

No Evidence of Granuloma


Large Bowel Mucosa – Minimal distortion of glandular architecture.

No abbesses

Polymorphs are seen in places on the surface of the epithelium.


Histology Diagnosis:

“Some features here are of Chronic Active Colitis and could be consistent of IBD or an infective cause must be considered”


GI Diagnosis:

“Mild Crohn’s Colitis but no evidence of Granuloma - inconclusive results”


Pentassa x 4g a day for 3 months then taper down. Steroids 5mg for 1, 2 or 3 months depending on need.

Diagnosis Oct 07 and then Aug 08: Patchy Ulcerative Pancolitis or Chrohn's Colitis to be confirmed after biopsy.
Medication: 4000mg Pentasa a day, 5mg Clipper Steroid (Beclometasone dipropionate) for 30 days

Veteran Member

Date Joined Apr 2007
Total Posts : 1366
   Posted 8/15/2008 12:18 PM (GMT -6)   
It seems then the diagnosis they're leaning towards is Crohn's Colitis, since your large intestine is involved in patchy areas but your small intestine doesn't appear to be. Since they say it's inconclusive though and mention Colitis, I would assume your GI would probably want/need to run more tests... Have you had a small bowel follow-through, where you have to drink Barium while they xray your abdomen?

Sorry it wasn't more conclusive for you :( I know how frustrating that can be. When is your next appointment with your doc?

Veteran Member

Date Joined Apr 2006
Total Posts : 733
   Posted 8/15/2008 12:27 PM (GMT -6)   
I didn't get that they are leaning towards Crohn's colitis, since the illeum came out normal.... I guess because of the right side of the colon being so inflamed? The GI diagnosis seems strange based on what I UNDERSTAND from the findings. I am no where close to becoming a doctor, though. Sounds like you have a lot of rectal inflammation and you aren't on any rectal meds. Insurance-wise it's better to have a diagnosis of Crohn's Colitis because then you qualify for the Crohn's meds that are not approved for UC yet. I would ask your doctor why the diagnosis is Crohn's Colitis and not just UC. What did he see exactly to come to that diagnosis and how will it effect any possibility of surgery/meds.
Diagnosed with Left-sided UC in 1995 at age 15, Prednisone, Rowasa & Hydrocort. Enemas, Proctofoam, Sulfasalazine, Asacol, Probiotics, Fish Oil, Aloe Juice, Canasa, Enotcort, Colazol, Anamantle, Remicade, etc... had 1 inch deep rectal ulcer 2004, put on Remicade, August 2007:Increased Remicade dosage-700mg every 6 weeks,diagnosed w/ Psoriatic Arthritis & Fibromyalgia Current meds: Clorazepate, Lomotil,  Tylenol pm, Lyrica started 1/17/08,  Humira started 4/4/08, 6MP started 6/24/08

Veteran Member

Date Joined Oct 2007
Total Posts : 1198
   Posted 8/15/2008 12:34 PM (GMT -6)   
He said it can't be UC as it has two patches, my other GI is leaning towards UC and a rare patch on the right.
I have had the small bowel follow through and they found no inflammation - it was sent for a 2nd opinion too and still no inflammation. They also found no inflammation on colonscopy of the first part of the small bowel which is 99% suggestive of Chrohn's.

Basically I have rectal inflammation and a bit on the other end of the colon - mild.

In short, I think they are still shocked that the 2nd year in a row with two different hospitals the results come back inconclusive and even suggest infective colitis!

Diagnosis Oct 07 and then Aug 08: 2 Patches of Mild Chrohn's Colitis with no Granuloma
Medication: 4000mg Pentasa a day, 5mg Clipper Steroid (Beclometasone dipropionate)

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