Anti-oxinants specifically DMSO

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men8ifr
Regular Member


Date Joined Jul 2008
Total Posts : 124
   Posted 8/28/2008 10:27 AM (GMT -6)   
A possible new treatment?
 
This follows on from another post but thought it deserved a new one
 
http://www.newtreatments.org/ga.php?linkid=1 click on the double blind trial at the bottom (ha ha) is a trial - looks to be funded by the company manufacturing the stuff but is it correct in saying a 100% remission rate within 3 weeks?
 
 
I was interested in it because (as i said in another post) I believe a member here found vitamin E enema's to help him greatly and both seem to work on the principle of being anti-oxidants
 
 
Ian

6 Asacol tabs/day
1 Pentasa Suppository / day
Fish oil 3/day (omega 3 only)
Multivitamin and mineral 1/day
Folic Acid 1/day
Aloe Vera 3/day
Specific Carbohydrate Diet SCD
Turmeric 3/day
Currently in no mans land between flare and remission


men8ifr
Regular Member


Date Joined Jul 2008
Total Posts : 124
   Posted 8/28/2008 10:29 AM (GMT -6)   
Extracts from Wiki

In a 1978 study at the Cleveland Clinic Foundation in Cleveland, Ohio, researchers concluded that DMSO brought significant relief to the majority of the 213 patients with inflammatory genitourinary disorders that were studied. They recommended DMSO for all inflammatory conditions not caused by infection or tumor in which symptoms were severe or patients failed to respond to conventional therapy.
Some people report an onion- or garlic-like taste after touching DMSO. (Onion and garlic also derive their stinginess from sulfoxides syn-propanethial-S-oxide and allicin.) In the medical field DMSO is predominantly used as a topical analgesic[6], a vehicle for topical application of pharmaceuticals, as an anti-inflammatory[7] and an antioxidant[citation needed]. It has been examined for the treatment of numerous conditions and ailments. The Food and Drug Administration (FDA) has approved DMSO usage only for the palliative treatment of interstitial cystitis. Medicinal-grade DMSO for this purpose is manufactured by Insource, Inc. under the name RIMSO.
Ian

6 Asacol tabs/day
1 Pentasa Suppository / day
Fish oil 3/day (omega 3 only)
Multivitamin and mineral 1/day
Folic Acid 1/day
Aloe Vera 3/day
Specific Carbohydrate Diet SCD
Turmeric 3/day
Currently in no mans land between flare and remission


suebear
Veteran Member


Date Joined Feb 2006
Total Posts : 5698
   Posted 8/28/2008 10:39 AM (GMT -6)   
Ian,

I would look for more current research information on DMSO. People have died from taking it; it somehow negatively affects the heart. The deaths have been since this research was done. I am not advising you not to try it but be careful with dosage.

Sue
dx proctitis in 1987
dx UC in 1991, was stable until 1998

1998 started prednisone, asacol, pentasa, nortriptylene, ativan, 6MP, rowasa enemas and suppositories, hydrocortisone enemas, tried the SCD diet, being a vegetarian, omega 3s, flax, pranic healing, yoga, acupuncture, probiotics

2000 lost all my B-12 stores and became anemic

2001 opted for j-pouch surgery- now living life med-free


men8ifr
Regular Member


Date Joined Jul 2008
Total Posts : 124
   Posted 8/29/2008 4:48 AM (GMT -6)   

I've done abit more digging but only came up with one reported death from a woman and the cause was unknown though she was taking DMSO at the time - from the numbers of people (and animals) using it this would seem rare but there again who wants to die.... Do you know when the UC trial was written?

If nothing else the proposed harber weiss reaction is certainly interesting and makes me wonder -is the tissue damage caused by the OH radicals this may tie up with hydrogen peroxide being able to cause acute ulcerative colitis and additionally the damage could be reduced or eliminated by most anti-oxidants....

 

 

 

 

 


Ian

6 Asacol tabs/day
1 Pentasa Suppository / day
Fish oil 3/day (omega 3 only)
Multivitamin and mineral 1/day
Folic Acid 1/day
Aloe Vera 3/day
Specific Carbohydrate Diet SCD
Turmeric 3/day
Currently in no mans land between flare and remission


men8ifr
Regular Member


Date Joined Jul 2008
Total Posts : 124
   Posted 8/29/2008 6:26 AM (GMT -6)   
When I do heavy exercise I always get worse the day or 2 after and have always wondered why - this bit of an article may explain it basically exercise produces oxidants and of interest hydrogen peroxide (used to produce colitis in rats I believe) and hydroxyl radicals are specifically mentioned - could this be why I feel worse? I'm interested to try loads of anti-oxidants before my next race and see if it helps I'm also taking quite a lot of vitamin E at the moment so we'll see how that goes...

"There is an apparent contradiction here, but the key point is this: all endurance activity is associated with oxidative stress, and the higher the intensity of the exercise, the greater the stress; but regular performance of such exercise generates an adaptive response which helps to protect the body against the effects of such stress. The increased oxidative stress observed during exercise is associated with an increase in production of chemicals known as free radicals and reactive oxygen species (ROS). Radicals and ROS produced as a result of exercise include superoxide (O-2), hydrogen peroxide (H2O2), nitric oxide (NO), and hydroxyl radicals (HO). These are highly active chemical species which can work on DNA, proteins and lipids in such a way as to cause molecular cell damage and cell injury, leading in turn to accelerated ageing and disease(1). Further, oxidants may contribute to muscle fatigue and injury through cellular changes in skeletal muscle. "

from http://www.pponline.co.uk/encyc/0888.htm


Ian

6 Asacol tabs/day
1 Pentasa Suppository / day
Fish oil 3/day (omega 3 only)
Multivitamin and mineral 1/day
Folic Acid 1/day
Aloe Vera 3/day
Specific Carbohydrate Diet SCD
Turmeric 3/day
Currently in no mans land between flare and remission

Post Edited (men8ifr) : 8/29/2008 5:30:07 AM (GMT-6)

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