If I can't tolerate melasamine??

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Veteran Member

Date Joined Jun 2008
Total Posts : 2865
   Posted 9/2/2008 11:37 AM (GMT -6)   
Ok, some of you know I am a senior diagnosed with UC proctosigmoiditis in May (but probably had it a long time).
I tried Canasa alone first - little help - then protofoam and Colazal (2x3) with little more help but still symptomatic.  Next was Rowasa (1/2 of dose every night) with 1x3 Colazal.  Side effects kept getting worse even as I cut the dosage.  So, I quit everything for UC on Friday except the probiotics and Imodium as needed.
My doc and NP were out of office all weekend so I have not contacted them.  NP will return tomorrow.  I have to call her. 
Ok, I know I should be on something - although UC is behaving for the most part.  I have not seen blood (but might be mixed in), two bm's mornings and no cramping but still little left-sided discomfort (awareness).  Taking 1/2 Imodium when going out or cramping.
Now - all the meds I have tried are melasamine, right?  I am not allergic to aspirin but have same problems - including Motrin for arthritis.  I can take for a while and then start getting nausea, stomach pains, sweating (chills) vertigo and feeling generally woozy and yucky (why I stopped). 
What is your experience with moving on to something else to help.  I have a mild to moderate case and surely not in remission but doing well. 
Of course, I will tell all this to my NP and she will discuss with doc but nice to hear what others have done here.

Elite Member

Date Joined Mar 2003
Total Posts : 10407
   Posted 9/2/2008 12:53 PM (GMT -6)   
Sounds like you truly can't tolerate the 5-ASA's. Usually the next group of meds to try are what are called the immunosuppressants (Imuran, 6-MP) or Sulfasalazine, which is actually an older drug but is tolerated by some who can't take 5-ASA's. If these don't provide adequate relief, biologicals such as Remicade and Humira are next. Don't despair, there are choices left, and more drugs are being developed all the time.
Judy - Southern US 
Moderate to severe left-sided UC (21 cm) diagnosed 2001.
Avascular necrosis in both shoulders is my "forever" gift from Entocort.
Colazal,  Remicade, Nature's Way Primadophilus Reuteri. In remission since April, 2006.
Co-Moderator UC Forum
Please remember to consult your health care provider when making health-related decisions.

Elite Member

Date Joined Apr 2004
Total Posts : 23551
   Posted 9/2/2008 2:55 PM (GMT -6)   
Have you tried Colocort yet? This is a steroid enema which is better then the Cortifoam since it goes higher up like the Rowasa.
Moderator for Allergies/Asthma and Co-moderator for UC
~Left sided Uc-'92-Colazal(9 daily),6mp(50-100mgs),Prilosec,Biotin,Forvia,Pro-Bio**Unable to tolerate Asacol, Rowasa or Canasa**~Year-round allergies-Singulair, Allegra~Secondary Reynauds Syndrome-'04-Norvasc~Spinal Stenosis(?)~Sacroiliitis-epidural injections~bulging and herniated discs C5/C6 & C6/C7~3rd epidural injection 9/4, Neurontin and Skelaxin
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