My Doctor has added Asacol

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Regular Member

Date Joined Aug 2008
Total Posts : 469
   Posted 9/3/2008 6:50 AM (GMT -6)   
My doctor has added 400mg 3 times a day.  1200 mg's a day seems high to me, but I am still new at this.  Does this seem like alot to anyone else?  Has anyone had difficulties w/ this drug?
Thanking you in advance for your input.
Will be choosing a probitotic today

Elite Member

Date Joined Apr 2004
Total Posts : 23551
   Posted 9/3/2008 8:40 AM (GMT -6)   
No, actually that is a small dose and barely a maintenance dose. The average dosing (of course depending on the severity of your Uc) is 6 or less a day for maintenance and 6-12 is a treatment dose. It seems like a lot of pills but really it isn't. But if it helps at the lesser dose then that is a good thing. I was on Asacol for 12 years before switching to Colazal. I became intolerant of mesalamines but before that, I had no troubles with it nor did I have any side effects.
Moderator for Allergies/Asthma and Co-moderator for UC
~Left sided Uc-'92-Colazal(9 daily),6mp(50-100mgs),Prilosec,Biotin,Forvia,Pro-Bio**Unable to tolerate Asacol, Rowasa or Canasa**~Year-round allergies-Singulair, Allegra~Secondary Reynauds Syndrome-'04-Norvasc~Spinal Stenosis(?)~Sacroiliitis-epidural injections~bulging and herniated discs C5/C6 & C6/C7~3rd epidural injection 9/4, Neurontin and Skelaxin
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Regular Member

Date Joined Jul 2008
Total Posts : 94
   Posted 9/3/2008 11:08 AM (GMT -6)   

I agree, that is a low dose for Asacol. 

I tried to take it two separate times and both times i had problems with severe headaches, nausea and loose stools.  As soon as i stopped the symptoms disappeared. 

Veteran Member

Date Joined Nov 2005
Total Posts : 2045
   Posted 9/3/2008 12:10 PM (GMT -6)   
I think your dose is too low to be effective.I take 1200mg three times a day when flaring and 800mg x 3 when in remission.
                                     keep the faith 

Zoton (lansoprazole)/pred/colofac


Veteran Member

Date Joined Mar 2007
Total Posts : 4538
   Posted 9/3/2008 1:31 PM (GMT -6)   
I agree with fatboyslim. I take 4,800 mg a day (this is the max. dose).
Diagnosed with UC March 2007; Asacol 4 tablets 3x/day; Rowasa nightly; Canasa weekly; Viactiv; Metamucil wafers; multivitamin

Regular Member

Date Joined Aug 2008
Total Posts : 469
   Posted 9/3/2008 1:45 PM (GMT -6)   
Then I suppose I should count my blessings does make me wonder though why he would prescribe this if the dosage is low? I will have to ask him next Monday as I will be there to take my husband in for his first scope. He will be 60 in January and has never had one. He's not real happy w/ his dw that I scheduled this, but it is important to make sure there is no cancer.

Thank you guys for your continued support

New Member

Date Joined Aug 2008
Total Posts : 15
   Posted 9/3/2008 2:14 PM (GMT -6)   
I started on 400 x 6 pills a day. Now on 400 x 12 cause i was stubborn and didn't see a GI for that first year. As soon as he saw me and read my file he but me on 12 a day. Worked great for 2 months, then this current flare.
Not sure what to think abotu Asacol now. Not sure if it doesn't help at all, or maybe it's helping and I'd be a lot worse right now without it.
Side effects? Well that's a tough one. I experienced all sorts of horrible things this last 16-17 months. Deppression, insomnia, FATIGUE, loss of appetite. But I always blamed the UC. Now i wonder, maybe it was partly the asacol. That's the frustrating thing for me, so many variables it's tough to really know.

SO how mild is your condition? Maybe the doc figures, better to start lower and see if you respond?
God will take you through hell, just to make it to heaven.

Veteran Member

Date Joined Mar 2008
Total Posts : 2855
   Posted 9/4/2008 1:47 PM (GMT -6)   
Ditto, large doses for flares is good (some might just move through you without dissolving anyway). I've had no side effects, 20+ years of it.
49 year old female, diagnosed UC/pancolitis 1985, no surgery but much suffering.
Asacol/5ASA maintenance for 20+ years, usually 3 pills 2x day. 
Currently tapering off presnisone from lingering flare;
August 2008 sought care of naturopathic doctor. Tested gluten intolerant and started gluten-free, soy-free, etc. diet which resolved flare. Also Replete probiotic, DGL (licorice root, slippery elm), Permeability Factors. Slow-release iron and B-12 shots for severe anemia.

Elite Member

Date Joined May 2003
Total Posts : 30971
   Posted 9/4/2008 10:13 PM (GMT -6)   
not necessarily true that large dosages are best for flares.....sometimes the larger the dosage, the more side effects that mimic a flare. go figure.

Best to start lower such as with 6 and increase if necessary....lower dosage asacol can work best with rectal meds.  You know..both ends approach. smilewinkgrin


*Heather*Status: mini flare Dec 28... tapered to every 4th night
~diagnosed January 1989 UC (proctosigmoiditis)
~5ASA: Asacol (6 daily) + Salofalk enemas (increase for flares tapered to maintenance)
~Bentylol (dicyclomine) 20mg as needed
~Probiotic 3(Natural Factors Protec) bedtime + 1 (Primadophilus Reuteri) occasionally
~multi-digestive enzymes as needed ....zymactive 3 - 5x daily
~Ranitidine,Pariet (reflux) Effexor XR 75mg;  Pulmicort/Airomir (asthma)
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS"  worth it !!!

Regular Member

Date Joined Jun 2008
Total Posts : 281
   Posted 9/4/2008 10:54 PM (GMT -6)   

I don't know about asacol, either.  When the drugs side effects are the same as the disease, how do you figure it out?  Or, it may have worked before and now I've hit a wall.  I find it hard to believe that I need more now when my dx is supposed to be mild. 

As a side note, I think it's important to approach treatment options a little slowly.  Gigi, I noticed you've started some probiotics and fiber that you wrote about it another thread.  The problem can be that if you have different symptoms or you keep flaring, it's hard to figure out which thing might be causing it.  For example, with this flare that began last month, I quit culturelle, Rowasa (to use cortenema instead), citracelle, and even using my Brita water filter all at the same time.  I was 50% better in two days.  

But I don't know what actually helped or which may have made the symptoms worse.  Was it what I stopped using or what I started?  Maybe just using the cortenema and taking lomotil took care of most of the problems. 

I'm trying to add stuff slowly now to see what works best for me.  Including spinach.  This is very much trial and error, and I hope the things you're trying work for you, and you let us know what works!    


Potato...  Female, 58, dx mild left sided ulcerative colitis 11/07
asacol 3 3x a day 
cortenema (generic) am & pm Rowasa every other day 
culturelle, benefiber wafers  generic acidophilus, metamucil wafers
children's vitamin, Vitamin E 400 mg
omeprazole 2x a day
oxazepam when needed, lomotil or ImodiumAD (but not in the same day)

Regular Member

Date Joined Aug 2008
Total Posts : 469
   Posted 9/4/2008 11:28 PM (GMT -6)   
Yes, I will keep you posted on what works.  Right now I am a bit frustrated.  I put in a 10 hour day at work and drove over 200 miles.  I should be exhausted but I can't sleep which is not normal.  Is this the meds the probiotic the psyillum the multi enzyme?  I don't know.  I am about ready to start back smoking for the nicotine as my quitting smoking is what prompted this.  Very frustrated right now - I apologize in advance, but I suppose sometimes we need to vent.  Also tired, that because of this disease my arthritis is acting up.  Oh Gigi, keep moving forward we have to.
multi enyme
meg probiotic

Veteran Member

Date Joined Dec 2006
Total Posts : 517
   Posted 9/6/2008 5:43 AM (GMT -6)   
I was taking 1200mg 3x/day for over two years. During that time I had occassional loose stools, but never any blood or mucous. However I was feeling really run down, tired, and lethargic. I got it into my head that I was allergic to the Asacol, talked my doc into the theory and we weaned me off. Big mistake. I felt better for a few days, but then I went into a full on flare that is now making me realize how good I had it 3 months ago.
Diagnosed w/ moderate UC in May '06, had symptoms for years prior to dx - currently flaring
Taking Asacol, Florastor, VSL#3, Wellbutrin XL, Prozac, multi-vitamin, Allegra, Lialda

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