Imuran stopped working?

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BadGutGirl
Regular Member


Date Joined May 2004
Total Posts : 187
   Posted 9/3/2008 9:53 AM (GMT -6)   
Hi all, for those of you with experience taking imuran - has anyone had great results with it that then seemed to suddenly stop? I'm trying to figure out this flare that I'm in. Other than increasing throat infections, taking imuran has been a blessing for me. I've been on it 1.5 years and really haven't gone into a bad flare since it kicked in a year ago. Now, for the past month I've been in flare central, and its getting worse and worse. I've been tested for c. diff and other bugs just in case it was that, and am waiting for the results.

However, I'm also left wondering.... is it possible that the imuran just stopped working? smhair

------------------
33 yr old, female.
Diagnosed with UC in 1996, symptoms since 1990
Currently in a UC flare since July 2008 *grrrr*
On Imuran 2mg/day, Primal Defence 2 tables/day, now added cortifoam for flare


Lucky777
Regular Member


Date Joined Aug 2008
Total Posts : 128
   Posted 9/3/2008 10:14 AM (GMT -6)   
I imagine that with the right catalyst and stars aligning that you can bust through any drug - I was on asacol for months and was doing fine and then I broke through it like the Kool-Aid pitcher guy comes through walls. I was taking 12 a day at the time and it came so fast and so hard that I was actually passing the asacol for 3 weeks - they didn't digest at all.
Sean - 31

UC Since April 2006, diagnosed 2007 (Flex-Sig)
4 x Liada (2 am 2 pm)
175mg Azathioprine
2 x Imodium
Remicade consult scheduled


jujub
Elite Member


Date Joined Mar 2003
Total Posts : 10407
   Posted 9/3/2008 10:28 AM (GMT -6)   
My immune system is powerful, and was able to overcome every drug I tried until Remicade. So yes, it could have stopped working.
Judy - Southern US 
 
Moderate to severe left-sided UC (21 cm) diagnosed 2001.
Avascular necrosis in both shoulders is my "forever" gift from Entocort.
Colazal,  Remicade, Nature's Way Primadophilus Reuteri. In remission since April, 2006.
 
Co-Moderator UC Forum
Please remember to consult your health care provider when making health-related decisions.


saskia
Regular Member


Date Joined Dec 2007
Total Posts : 31
   Posted 9/3/2008 12:25 PM (GMT -6)   
Imuran stopped working for me.  I started on 75 mg / day in May 2007 and started to flare in early September.  In between, however, I felt great.  My GI increased my dose to 100 mg / day this past June because I was having difficulty achieving remission with other meds and I have felt pretty good since (Imuran does not reduce aching / inflammation in joints for me).  I feel like I am now playing a waiting game - waiting to see if Imuran stops working again.
*saskia*
pan colitis (diag: Nov 05)
Meds: salofalk7 to 10 tabs/day depending on disease status; imuran 75mg/day; entocort when flaring; cortifoam when flaring; pantoloc; VSL#3; vitamin D and calcium; fosomax


nsg121
Regular Member


Date Joined Dec 2006
Total Posts : 31
   Posted 9/3/2008 12:47 PM (GMT -6)   

Hi,

    Well 6-MP stopped working for me about 2 months ago and now we switched off 6-MP and am on Prednisone for a little bit while they get the paper work done for Remicade, hopefully I can start that soon within the next couple of weeks.  I was pretty good on 6-MP for about 8 months but then I flared and it just kept on getting worse.

 

~Nsg


Red_34
Elite Member


Date Joined Apr 2004
Total Posts : 23551
   Posted 9/3/2008 1:37 PM (GMT -6)   
I have been on 6mp for almost 2 years. I would have to say that it did a fairly good job of keeping me out of severe flares but I was flaring nonetheless (albeit more mildly) even after dosage increases. My GI has performed a couple of Prometheus Metabolites test and even after dose increases, the number never went up. He pretty much said that my metabolism is not working right so I can't get the best use out of this med. He won't increase my dose anymore because it just won't work and it could become toxic to me. I have come to the decision that I want off these meds and I plan on bringing up surgery when I see my GI next week. But yes, I do believe that you can become tolerant to the med and your body doesn't respond as well to it over time. Have you had any Prometheus testing lately?


 @--->--SHERRY--<---@
Moderator for Allergies/Asthma and Co-moderator for UC
~Left sided Uc-'92-Colazal(9 daily),6mp(50-100mgs),Prilosec,Biotin,Forvia,Pro-Bio**Unable to tolerate Asacol, Rowasa or Canasa**~Year-round allergies-Singulair, Allegra~Secondary Reynauds Syndrome-'04-Norvasc~Spinal Stenosis(?)~Sacroiliitis-epidural injections~bulging and herniated discs C5/C6 & C6/C7~3rd epidural injection 9/4, Neurontin and Skelaxin
To help Healingwell - click here: DONATE
 
 
 
 

 
 


BadGutGirl
Regular Member


Date Joined May 2004
Total Posts : 187
   Posted 9/3/2008 4:46 PM (GMT -6)   
What is the Prometheus Metabolites test? This is something I've never heard of before.

------------------
33 yr old, female.
Diagnosed with UC in 1996, symptoms since 1990
Currently in a UC flare since July 2008 *grrrr*
On Imuran 2mg/day, Primal Defence 2 tables/day, now added cortifoam for flare


Red_34
Elite Member


Date Joined Apr 2004
Total Posts : 23551
   Posted 9/3/2008 5:00 PM (GMT -6)   
This is a test they send to Prometheus labs to see how you are metabolizing the medication. If you have never had this done before, ask your doc to do it. But I wouldn't recommend it until you clear it thru your insurance company to see if they will cover it because it can be costly.
 @--->--SHERRY--<---@
Moderator for Allergies/Asthma and Co-moderator for UC
~Left sided Uc-'92-Colazal(9 daily),6mp(50-100mgs),Prilosec,Biotin,Forvia,Pro-Bio**Unable to tolerate Asacol, Rowasa or Canasa**~Year-round allergies-Singulair, Allegra~Secondary Reynauds Syndrome-'04-Norvasc~Spinal Stenosis(?)~Sacroiliitis-epidural injections~bulging and herniated discs C5/C6 & C6/C7~3rd epidural injection 9/4, Neurontin and Skelaxin
To help Healingwell - click here: DONATE
 
 
 
 

 
 

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