I can relate, more that even water sometimes hurts to go down first thing in the morning. I attribute it to reflux.
Have you had an upper endoscopy done?
If not...you should, for what you're feeling isn't normal.
You could try eating firstly before taking your pills?
If your pills are gel capsules, they can sometimes feel like they stick (or actually do)..maybe take some honey before taking them, or taking a few sips of water before the pills?
You could also consider to change the prilosec to pariet....it's a newer ppi.
I feel your pain...
*Heather*Status: mini flare Dec 28... tapered to every 4th night
~diagnosed January 1989 UC (proctosigmoiditis)
~5ASA: Asacol (6 daily) + Salofalk enemas (increase for flares tapered to maintenance)
~Bentylol (dicyclomine) 20mg as needed
~Probiotic 3(Natural Factors Protec) bedtime + 1 (Primadophilus Reuteri) occasionally
~multi-digestive enzymes as needed ....zymactive 3 - 5x daily
~Ranitidine,Pariet (reflux) Effexor XR 75mg; Pulmicort/Airomir (asthma)
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS" worth it !!!