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Regular Member

Date Joined Aug 2008
Total Posts : 469
   Posted 9/10/2008 6:45 AM (GMT -6)   
I just started on Asacol Monday.  Taking 6 tablets a day.  I feel this med is making me feel sleepy and I don't have an appetite.  I was exhausted Monday evening, but then I chalked it off to the fact that I had been at the hospital w/ my Jim that day.  Yesterday I worked and went to bed at 7:00 p.m. and slept until Jim woke me at 5:30 a.m.  It will be interesting to see what happens today.  I am off work, do have things to do, but will see how sleepy I get.  I also have been having to force myself to eat.  Appetite is zilcho - zero.  I ate a tuna sandwitch and spinach yesterday was all I could handle. 
Does anyone else experience this?  If so, does it go away after ones body gets use to the med?
Thanking you in advance..........
Diagnosised 8/25/08
Mega Probiotic
Multi Enzyme
Today starting on nico patch

Veteran Member

Date Joined Dec 2007
Total Posts : 1028
   Posted 9/10/2008 7:36 AM (GMT -6)   
I did not have that with Asacal and I think I was on 12/day. Do you think the tiredness is just because you have active disease that is draining you, and maybe not from the meds. How were you feeling beofre your dx? Were you this tired then or did it start after the meds? As for the appetite, I NEVER feel like eating while I am feeling crummy. The appetite will come back as you start to feel better. Also, from your posting above it seems like you started to take a lot of pills after your dx. Any one of those things or any combination of those together may be giving you your issues. This is a trial and error disease. You will have to try some different things to see what works for you. But you will get there. Hang in there. Talk to your doctor and see if there is something you are missing--what are the side effects of these drugs and the otc things you are taking. Then experiment with yourself to see if you can get any relief. I keep a food journal and in that I write down all the meds and OTC drugs I take. That way if I feel really crummy I can narrow it down and if I feel really great, I know what I have to do. You will get there, it just takes some time. Good luck and I hope you feel better soon.
diagnosed with left-sided UC in 1997. (45cm)
Currently on 10mg Prednisone
12 caps of colazal    9 caps Colazal
2 rowasa enemas nightly
35, female

New Member

Date Joined Feb 2008
Total Posts : 5
   Posted 9/10/2008 8:08 AM (GMT -6)   
Hi,I was on Asacol 12 pills a day for 5 years.i never had side effects.It worked wonders and I actually lived a very flare free life while on it.I would have some tests done to see if something else is making you tired.I hope it starts working for you.Fairbr

Regular Member

Date Joined Aug 2008
Total Posts : 469
   Posted 9/10/2008 8:13 AM (GMT -6)   
Thank you, I will start a journal and both of you are most likely right w/ my fatigue being the UC. I had it before meds, just seemed this week, starting on the asacol it has been worse. It most likely is the fact that I had 2 busy days in a row and just need some rest.


Diagnosised 8/25/08
Mega Probiotic
Multi Enzyme
Today starting on nico patch

Elite Member

Date Joined Apr 2004
Total Posts : 23551
   Posted 9/10/2008 8:59 AM (GMT -6)   

Here are the side effects of Asacol and yes a tired feeling is among them.

Less serious side effects may include:

  • mild nausea, vomiting, stomach cramps, diarrhea, gas;
  • fever, sore throat, or other flu symptoms;
  • constipation;
  • headache or dizziness;
  • tired feeling; or
  • skin rash.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect

Moderator for Allergies/Asthma and Co-moderator for UC
~Left sided Uc-'92-Colazal(9 daily),6mp(50-100mgs),Prilosec,Biotin,Forvia,Pro-Bio**Unable to tolerate Asacol, Rowasa or Canasa**~Year-round allergies-Singulair, Allegra~Secondary Reynauds Syndrome-'04-Norvasc~Spinal Stenosis(?)~Sacroiliitis-epidural injections~bulging and herniated discs C5/C6 & C6/C7~3rd epidural injection 9/4, Neurontin and Skelaxin
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Tainted Butterfly
New Member

Date Joined Sep 2008
Total Posts : 6
   Posted 9/11/2008 5:32 PM (GMT -6)   
I just started Asacol 3 days ago. I have had severe headaches and tiredness as side effects.

Regular Member

Date Joined Jun 2008
Total Posts : 45
   Posted 9/11/2008 9:57 PM (GMT -6)   
I take Asacol 12 per day. I was originally told to take 6 in the morning, and 6 at dinner. That resulted in terrible fatigue, and a general sense of disorientation. When I switched to 4 pills at breakfast, 4 around 4:00 in the afternoon and 4 at around 10 pm, all my symptoms stopped. Maybe you can see if adjusting the time you take the pills works.
Gale--New York Diagnosed with UC 6/9/08
On Asacol 4 pills 3x/day
Iron supplement, fish oil, magnesium, caltrate D, cerefolin NAC,
probiotics, alpha lipoic acid.

Veteran Member

Date Joined Mar 2008
Total Posts : 2855
   Posted 9/12/2008 9:49 AM (GMT -6)   
I have to wonder if all these side effects are really caused by the Asacol. My understanding is that Asacol is basically just aspirin (non-steroid anti-inflammatory) with a coating that keeps it from dissolving until it gets to the large colon. That's why if your colon is too active, sometimes it doesn't dissolve at all but goes right through, into the toilet! Talk about flushing money away...

I participated in the study for this drug in the late 1980s before it was approved, and they took note of everything I experienced, even if it likely was just caused by my disease or was caused by something else entirely. So I don't take lists of side effects too seriously. I think it is a very mild drug, really, it just gets through to the right place which isn't easy and makes it special.
49 year old female attorney, diagnosed UC/pancolitis 1985, no surgery but much suffering.
Asacol/5ASA maintenance for 20+ years, usually 3 pills 2x day. 
Currently tapering OFF prednisone from lingering flare;
August 2008 sought care of naturopathic doctor. Tested gluten intolerant and started gluten-free, soy-free, etc. diet which resolved flare. Also Replete probiotic, DGL (licorice root, slippery elm), Permeability Factors. Slow-release iron and B-12 shots for severe anemia.
Sept: Mild case of thrush in throat, prescribed antifungal mouthwash.

New Member

Date Joined Feb 2009
Total Posts : 1
   Posted 2/25/2009 1:00 PM (GMT -6)   
I often get headaches the first 3 days of a flare when I take Asacol 6 times daily. I'm fatigued, but I believe that has more to do with the flare itself.

Forum Moderator

Date Joined Dec 2008
Total Posts : 16741
   Posted 2/25/2009 6:09 PM (GMT -6)   
I am tired because I am anemic. I don't think Asacol makes it any better or any worse. Have you had your blood checked for iron?

Diagnosed with proctitis in March 2007 - Treated with Canasa 2x Daily
Diagnosed with UC December but had symptoms months ago - Treating with Asacol (feel hopeless)

UC Fighter
Regular Member

Date Joined Oct 2007
Total Posts : 89
   Posted 2/25/2009 11:52 PM (GMT -6)   
I tried the asacol for a while, but found that even taking 2 per day that it irritated my colon and I never was able to get into remission. Weird huh? I decided to go back to the sulfasalazine (which also irritates if I take too much), and I've had better results. Slow, but getting better.
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