St Johns Wort proven to reduce symptoms in mice

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men8ifr
Regular Member


Date Joined Jul 2008
Total Posts : 124
   Posted 9/10/2008 6:56 AM (GMT -6)   
It's nice to have some scientific back-up for alternative medicines
 

The Effect of Hypericum perforatum (St. John's Wort) on Experimental Colitis in Rat.

Department of Pharmacology, Medical Faculty, Adnan Menderes University, Aydin, 09100, Turkey, tdost@adu.edu.tr.

The aim of the present study was to investigate the effect of Hypericum perforatum (HP) on the inflammatory and immune response of colonic mucosa in rat with induced inflammatory bowel disease and that on various enzyme activities in blood and bowel tissue. Male Wistar albino rats were divided into three main groups: control, third day, and seventh day of colitis. Third-day and seventh-day groups were divided into four subgroups. Colitis was induced in all groups except the control group by 2,4,6-trinitrobenzene sulfonic acid (TNBS). The colitis group received saline; treatment groups received HP extract (50, 150, and 300 mg/kg/day, respectively). Glutathione (GSH), catalase (CAT), and malondialdehyde (MDA) activities in blood were measured. Catalase, myeloperoxidase (MPO), glutathione peroxidase (GSH-Px), glutathione reductase (GR), malondialdehyde, and nitric oxide (NO) activities were measured from tissue samples. Colonic damage was significantly reduced by HP extract. Macroscopic scoring of colonic damage significantly reduced in groups given HP extract compared with in the colitis group (P < 0.001). Blood catalase levels were reduced in the HP (150 mg/kg/day) compared with the colitis group (P < 0.01). Blood GSH levels significantly increased in groups treated with HP compared with control (P < 0.001) on the third and seventh day. Tissue GR levels reduced in the colitis and HP (50 mg/kg/day) groups compared with control (P < 0.05). Tissue MPO activity increased in the colitis and treatment groups compared with control (P < 0.007). GSH-Px levels increased in the colitis group compared with control at day 3 (P = 0.006). HP has a protective effect on TNBS-induced inflammatory bowel disease (IBD), probably due to an anti-inflammatory and antioxidant mechanism.


Ian

6 Asacol tabs/day
1 Pentasa Suppository / day
Fish oil 3/day (omega 3 only)
Multivitamin and mineral 1/day
Folic Acid 1/day
Aloe Vera 3/day
Specific Carbohydrate Diet SCD
Turmeric 3/day
Currently in no mans land between flare and remission


Sara14
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Date Joined Mar 2007
Total Posts : 4201
   Posted 9/10/2008 1:19 PM (GMT -6)   
Very interesting. Thanks for posting.
Diagnosed with UC March 2007; Asacol 4 tablets 3x/day; Rowasa nightly; Canasa weekly; Viactiv; Metamucil wafers; multivitamin


sweetmelody
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Date Joined Aug 2007
Total Posts : 650
   Posted 9/10/2008 1:28 PM (GMT -6)   
Isn't St. Johns Wort just a natural form of prozak or something... for like depression????
Kara, 21F Married.


Medications:

<FONT color=green>Lialda - 4 pills in the morning w/ food.
Steroid Enemas


Sara14
Veteran Member


Date Joined Mar 2007
Total Posts : 4201
   Posted 9/10/2008 1:29 PM (GMT -6)   
Yeah, it is used as a natural supplement by some for depression.
Diagnosed with UC March 2007; Asacol 4 tablets 3x/day; Rowasa nightly; Canasa weekly; Viactiv; Metamucil wafers; multivitamin


sweetmelody
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Date Joined Aug 2007
Total Posts : 650
   Posted 9/10/2008 1:29 PM (GMT -6)   
yeah.. no thanks.
Kara, 21F Married.


Medications:

<FONT color=green>Lialda - 4 pills in the morning w/ food.
Steroid Enemas


jujub
Forum Moderator


Date Joined Mar 2003
Total Posts : 10407
   Posted 9/10/2008 4:59 PM (GMT -6)   
Caution to women: St. John's Wort has been known to render oral contraceptives ineffective. Just FYI.
Judy - Southern US 
 
Moderate to severe left-sided UC (21 cm) diagnosed 2001.
Avascular necrosis in both shoulders is my "forever" gift from Entocort.
Colazal,  Remicade, Nature's Way Primadophilus Reuteri. In remission since April, 2006.
 
Co-Moderator UC Forum
Please remember to consult your health care provider when making health-related decisions.


men8ifr
Regular Member


Date Joined Jul 2008
Total Posts : 124
   Posted 9/11/2008 3:18 AM (GMT -6)   
Well started it last night - will try to keep you updated...
Ian

6 Asacol tabs/day
1 Pentasa Suppository / day
Fish oil 3/day (omega 3 only)
Multivitamin and mineral 1/day
Folic Acid 1/day
Aloe Vera 3/day
Specific Carbohydrate Diet SCD
Turmeric 3/day
Currently in no mans land between flare and remission


LondonRed
Veteran Member


Date Joined Oct 2007
Total Posts : 1190
   Posted 9/11/2008 3:18 AM (GMT -6)   
I am going to try it too for my anxiety.

Diagnosis Oct 07 and then Aug 08: Inditerminate Patches of Mild Colitis (including Rectum) - Currently Minor Bleeding
Medication: 1000mg Mesalazine Suppository at night.


sweetmelody
Veteran Member


Date Joined Aug 2007
Total Posts : 650
   Posted 9/11/2008 3:21 AM (GMT -6)   
i personally was insulted when my mil told my hubby to suggest this to me. I think it's bull that she thinks i need meds for depression. And not to mention my parents put me on depression pills when I was younger and had to take me off because they made me so crazy... they're like... CRAZY.
Kara, 21F Married.


Medications:

<FONT color=green>Lialda - 4 pills in the morning w/ food.
Steroid Enemas


LondonRed
Veteran Member


Date Joined Oct 2007
Total Posts : 1190
   Posted 9/11/2008 3:36 AM (GMT -6)   
They are known to have interractions with other drugs so be careful.

Diagnosis Oct 07 and then Aug 08: Inditerminate Patches of Mild Colitis (including Rectum) - Currently Minor Bleeding
Medication: 1000mg Mesalazine Suppository at night.


Eva Lou
Veteran Member


Date Joined Sep 2006
Total Posts : 3442
   Posted 9/11/2008 9:11 AM (GMT -6)   
but this is so interesting, especially with the Reuters article about IBD & depression! You gotta wonder, treat the depression & perhaps the IBD will lessen? I know a few people on here who take anti-anxiety meds or anti-depressants- I wonder if their UC improved after being on those meds or not. Feel free to comment!

diagnosed with UC '02
meds-
Asacol- 8 tabs/day
Remicade-10mgs/kg- since 4/07
Imuran- 150mgs/day
Culturelle
Fiber supplement
 
 
 


jujub
Forum Moderator


Date Joined Mar 2003
Total Posts : 10407
   Posted 9/11/2008 9:46 AM (GMT -6)   
A lot of people on here take anti-depressants. They didn't make my IBD any better, but I no longer wish I could just die at least three times every day. The change for me happened within a week. I'd actually forgotten what it was like to not be depressed.
Judy - Southern US 
 
Moderate to severe left-sided UC (21 cm) diagnosed 2001.
Avascular necrosis in both shoulders is my "forever" gift from Entocort.
Colazal,  Remicade, Nature's Way Primadophilus Reuteri. In remission since April, 2006.
 
Co-Moderator UC Forum
Please remember to consult your health care provider when making health-related decisions.


LondonRed
Veteran Member


Date Joined Oct 2007
Total Posts : 1190
   Posted 9/11/2008 12:15 PM (GMT -6)   
500mg - one a day seems like a good option but can cause D as a side effect.

Diagnosis Oct 07 and then Aug 08: Inditerminate Patches of Mild Colitis (including Rectum) - Currently Minor Bleeding
Medication: 1000mg Mesalazine Suppository at night.


Red_34
Forum Moderator


Date Joined Apr 2004
Total Posts : 23551
   Posted 9/11/2008 4:12 PM (GMT -6)   
I was on St. John's Wort a couple years ago for mild depression. It made my mood change drastically. In fact, my hubby wanted to duct tape me to the wall because I was bouncing off the walls like a little ray of sunshine :) It took about 2 weeks before I noticed any improvement but I didn't notice it help my Uc any.
 @--->--SHERRY--<---@
Moderator for Allergies/Asthma and Co-moderator for UC
~Left sided Uc-'92-Colazal(9 daily),6mp(50-100mgs),Prilosec,Biotin,Forvia,Pro-Bio**Unable to tolerate Asacol, Rowasa or Canasa**~Year-round allergies-Singulair, Allegra~Secondary Reynauds Syndrome-'04-Norvasc~Spinal Stenosis(?)~Sacroiliitis-epidural injections~bulging and herniated discs C5/C6 & C6/C7~3rd epidural injection 9/4, Neurontin and Skelaxin
To help Healingwell - click here: DONATE
 
 
 
 

 
 


Sara14
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Date Joined Mar 2007
Total Posts : 4201
   Posted 9/14/2008 7:34 PM (GMT -6)   
Red, do you remember what dose you took and for how long? I'm thinking about trying this.
Diagnosed with UC March 2007; Asacol 4 tablets 3x/day; Rowasa nightly; Canasa weekly; Viactiv; Metamucil wafers; multivitamin


LondonRed
Veteran Member


Date Joined Oct 2007
Total Posts : 1190
   Posted 9/15/2008 2:53 AM (GMT -6)   
The dose for anxiety/depression etc is 300mg x 3 a day after meals I believe.

Diagnosis Oct 07 and then Aug 08: Inditerminate Patches of Mild Colitis (including Rectum) - Currently Minor Bleeding
Medication: 1000mg Mesalazine Suppository at night.


Red_34
Forum Moderator


Date Joined Apr 2004
Total Posts : 23551
   Posted 9/15/2008 4:51 AM (GMT -6)   
No Sara, I'm sorry but I don't. It was what ever mg's I found at my local drug store. I think I took it for about 6 months or so but I didn't see any result from it for about 2 weeks.


 @--->--SHERRY--<---@
Moderator for Allergies/Asthma and Co-moderator for UC
~Left sided Uc-'92-Colazal(9 daily),6mp(50-100mgs),Prilosec,Biotin,Forvia,Pro-Bio**Unable to tolerate Asacol, Rowasa or Canasa**~Year-round allergies-Singulair, Zyrtec~Secondary Reynauds Syndrome-'04-Norvasc~Spinal Stenosis(?)~Sacroiliitis-epidural injections~bulging and herniated discs C5/C6 & C6/C7~3rd epidural injection 9/4, Neurontin and Skelaxin
To help Healingwell - click here: DONATE
 
 
 
 

 
 

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