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Regular Member

Date Joined Jan 2008
Total Posts : 39
   Posted 9/15/2008 12:15 PM (GMT -6)   
Just curious what the lowest dose of sulfasalazine that anyone has been on. I am suppose to take 3 pills twice a day, but due to my pregnancy, if I take the pills in the morning, I usually end up throwing them up. I have just been taking 4 pills @ night. Just wondering if this is enough to even do anything. Thanks!
Diagnosed in Jan 2007, but had bowel issues for year
Took Asacol for 1 year (no help) and Prednisone twice (60mg was the most)
Currently taking Sulfasalazine - 4 pills 2x a day
Hospitalized in Jan 2008 and then again in Feb 2008 (IV steroids) for 9 days
Was using VSL #3, but it made me throw up (I'm pregnant and nauseous)
Rowasa enemas as needed
33 weeks pregnant and counting . . . . . .
Prenatal Vitamin
150mg Zantac twice a day (for acid reflux and nausea)

Veteran Member

Date Joined Apr 2007
Total Posts : 1366
   Posted 9/15/2008 1:04 PM (GMT -6)   
Not sure, I was just prescribed this today and it's two pills three times a day for me (so the same dosage). He didn't mention if it was a low or high dose though.

Female, 23, Ulcerative colitis (pancolitis) for 8 years so far; GERD; gastritis; osteopenia in femur head & lumbar spine from long term prednisone use....

Current Meds:
Lexapro 10mg, Lialda 2 pills a day, Rowasa enemas nightly


Regular Member

Date Joined Oct 2007
Total Posts : 348
   Posted 9/15/2008 2:03 PM (GMT -6)   
I believe that you should take it spread out through the day. I am on 6 per day, I do 2 in the am, afternoon and early evening. I understand if you are throwing up in the morning it would be difficult to keep them down, perhaps if you are usually done throwing up by a certain time, then you can take the first 2 after that.

DOSING: Doses range from 500mg to 2000mg, and dosing intervals range from every 6 hours to every 12 hours, depending on the clinical condition of the patient. Higher doses have also been used. Sulfasalazine should be taken with a full glass of water after meals or with food to minimize stomach upset. Patients with kidney diseases may need to use lower doses of sulfasalazine.

DRUG INTERACTIONS: Sulfasalazine may cause reduced absorption of folic acid and of digoxin.

Have you also been giving a scrip for folic acid?
Congrats! on your pregnancy, hope your morning sickness ends soon!!

South of Boston, Ma
diagnosed with uc 27 years ago.  Enojoyed 20 year remission with just minor blips here and there (approximately 16 of those years without any meds)
In a flare for 2 very long years which Asacol didn't help at all.  Finally in remission again since Jan 2008, can't believe it..............
currently on Sulfasalazine 2 tabs 3x day. Folic acid, mesalamine enema once a week. Omega 3, Probiotics, multi vitamin, calcium supplement, Biotin 5000mcg, Fibercon.

Post Edited (munchkindd) : 9/15/2008 1:12:50 PM (GMT-6)

Regular Member

Date Joined Feb 2007
Total Posts : 212
   Posted 9/15/2008 6:01 PM (GMT -6)   
I've never been pregnant so I can't relate, but during my worst flare I had a hard time keeping the morning pills down. If you eat a banana or some toast then take the pills it's easier on the stomach. I would also chew two tums with the pills and that settled things down. Stay away from anything that smells bad to avoid further stomach upset. I know it sounds weird, but anything that smelled...funky....would have me throwing up immediately.
- DXed with "left sided" UC in 1998. DXed with "proctitis" Oct. 2007
- Sulfasalazine 3 500mg tabs twice daily
- 500mg Vitamin C, 1 Multivitamin, L-Glutamine
- Max Acidophillis EC Capsules 350Mg(7 types of bacteria with over 42 billion viable cells) with 50 Mg colostrum & 50 Mg FOS(fructo-oligosaccharides)
- Experimenting with this or that on occasion. Always open to new ideas.
- Colonoscopies - 2 (Due for my next one ASAP)
- Strangely I find that eating a turkey and ham sub from Subway with lots of vegis will help me come out of a flare. Why I don't know. I stay away from fats or my D will just get worse.

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