My speculation on MRSA and UC

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doors12
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Date Joined Jul 2006
Total Posts : 689
   Posted 10/1/2008 3:37 PM (GMT -6)   
I am suspicious of the role of Staph bacteria.  We've all noticed MRSA in the news and moving beyond hospital acquired to community acquired.  One theory I have is that some mutated form of Staph colonizes a person's system, is recongized by the body as bad which overstimulates the immune system and inflammatory response.  Antibiotic use could then be the "last straw," devastating the few remaining competing "normal" Staph bacteria and causing the system to be overrun by the bad mutated type (for instance drug resistant staph).
 
From what I understand, Staph colonizes most people's nasal mucosa and could therefore be fairly easily communicated to others.  Food contamination and contact with contaminated surfaces could be two other ways of spread.
 
 
The concept of UC caused(or triggered I should say) by antibiotic use is well known.  Go to wikipedia and look up the history of Penicillin and you will notice that it was discovered as a ring of emptiness in a culture of the staph bacteria.  Penicillin is a fungus.  This seems to be a real easy tie-in to 'antibiotic' colitis if you realize that antibiotics were apparently mold/fungus.  Maybe the concept could be extended from
 
antibiotic-->colitis to:
fungus(bacterial inhibition)-->colitis
 
or even to the idea that (bacterial REcolonization)--> colitis [such as recolonization with MRSA or something similar wiping out the native Flora]
 
This probably isn't groundbreaking to many of you, as I assume that's what the whole probiotic approach is about.  But it seems to me that if this is a viable hypothesis, no real progress would be seen unless researchers isolate WHAT bacteria is doing the recolonization, so that it can be targeted or replaced.
 
Other reasons I am suspicious of Staph and it's relation to UC are that I was getting terrible cystic, subcutaneous welts (imagine acne but worse) which I self-diagnosed as folliculitis.  Staph or strep bacteria can cause folliculitis.  I have cured this problem nearly completely by using Head and Shoulders shampoo with some active ingredient with Zinc.
 
(6:38PM)  I'm now running goolgle searches on "Staph Enterocolitis"
 

Some links:

http://www.natren.com/pages/staphyloccus.html

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1215483

http://www.biomedcentral.com/1471-2334/7/105

One study on this topic:  http://cat.inist.fr/?aModele=afficheN&cpsidt=1022821

(Folliculitis caused by Staph):

http://www.dermatologychannel.net/follicle/folliculitis.shtml

Zinc pyrithione (Head and Shoulders) and Staph:

http://en.wikipedia.org/wiki/Pyrithione_zinc

 


Diagnosed with Ulcerative Colitis 6/2006 at age 26 after sudden E.R. visit
~Pancolitis (Mild to Moderate)
 ~I had Mono in 2000
On Colazal 3x3/day; Folic Acid 1mg; Calcium/Magnesium/Zinc combo
In remission about 2-3 months after E.R. but not back to normal!
 
~Interested in finding a cure/making sense out of U.C. and philosophical and psychological aspects of UC and "Stress" and Personal Development issues with Chronic Illnesses. 

Post Edited (doors12) : 10/1/2008 7:46:17 PM (GMT-6)


Probiotic
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Date Joined Mar 2007
Total Posts : 2832
   Posted 10/1/2008 3:43 PM (GMT -6)   
My ten year total and med free remission ended gradually after antibiotic use for strep. Unfortunately, my remisison was so total and complete that I had conivinced myself I had been misdiagnosed and wasn't researching or doing anything preventive at the time. C'est la vie. Now, with active disease for years, I can dump ten tons of probiotics in my system and it makes only a small difference. But if I ever get into a lasting remission I will certainly keep pounding them down.
Pancolitis 20 years ago, full med-free remission 10 years,
Flaring or simmering on and off ever since
10 20 17.5 15 12.5 10 mg 8 7.5 20 mg pred, 100 mg Imuran
Probiotics (Primal Defense and others), TSO, hookworm
Turmeric/circumin, boswellia, fish oil, many vits/minerals
Lower-carb version of Specific Carb Diet (SCD)
 
 
 


Deacon Blues
Regular Member


Date Joined Oct 2006
Total Posts : 304
   Posted 10/1/2008 10:02 PM (GMT -6)   
Probiotic said...
My ten year total and med free remission ended gradually after antibiotic use for strep. Unfortunately, my remisison was so total and complete that I had conivinced myself I had been misdiagnosed and wasn't researching or doing anything preventive at the time. C'est la vie. Now, with active disease for years, I can dump ten tons of probiotics in my system and it makes only a small difference. But if I ever get into a lasting remission I will certainly keep pounding them down.

I would be interested in hearing about your 10 year med-free remission...have you posted it hear before?
                                                                                                           D
                                                      
Diagnosed with UC in 1999
PANCOLITIS-mild to moderate
3-400mg Asacol 3x per day
44 yrs old


ucwarrior
Regular Member


Date Joined Jul 2008
Total Posts : 298
   Posted 10/2/2008 3:31 AM (GMT -6)   
Usually a stool culture is performed to rule out bacterial infection upon diagnosis of UC. Also, most food poisonings run their course in a few days. With UC, it lasts much longer. You are correct in theorizing that a bacterial imbalance is likely responsible for UC flares, I share the same mindset.

However... I think it can "any" type of pathogenic organisms, not just staph, that can have the effect of producing imbalance and disrupting existing bowel microflora. Candida yeast, pathogenic bacteria present abnormal amounts, viruses, protozoa, etc. Regardless of the antigen, the outcome seems to be chronic inflammation with symptoms that are brought on by a localized immune response.

I speculate that UC patients are highly susceptible to any pathogenic invasion/overgrowth of the gut, regardless of the organism. It is the immune response that makes UC what it is and does most of the damage. TH1 cells are produced by the body in response to invaders as an immunological response. Much research suggests UC patients tend to lack production of adequate amounts of the TH2 cells that turn it off. The immune system runs unchecked. Viola! Flare city here we come.

I like your thinking, it is creative and 'outside of the box' it is going to take someone with creativity and passion to figure this disease out because it has stumped many eggheads out there. I commend you for being creative and obviously very resourceful.

Peety
Veteran Member


Date Joined Mar 2008
Total Posts : 2855
   Posted 10/2/2008 12:56 PM (GMT -6)   
I think some of you have done more research and have more information about this than any of my doctors have exhibited. That is, until I went to the naturopathic doctor, who explained all this to me and gave me the probiotics (when my GI was always indifferent about them). Understanding it will help me maintain this rare remission, I think. It took more than 20 years!
49 year old female attorney, diagnosed UC/pancolitis 1985, no surgery but much suffering.
Asacol/5ASA maintenance for 20+ years, usually 3 pills 2x day. Use prednisone & Rowasa for flares. 
August 2008 sought care of naturopathic doctor. Tested gluten intolerant and started gluten-free diet, also none of the other foods tested sensitive to (cow's milk, soy, tomato, egg white, others)
Achieved remission for the first time in many, many years! 
Replete probiotic. Slow-release iron and B-12 shots for anemia.
 


Peety
Veteran Member


Date Joined Mar 2008
Total Posts : 2855
   Posted 10/2/2008 12:58 PM (GMT -6)   
Oh, and I was treated for MRSA with a new, strong antibiotic back in April or May. And I still managed to get into remission with strong probiotics, starting in August. But I should have been told to take them at that time.
49 year old female attorney, diagnosed UC/pancolitis 1985, no surgery but much suffering.
Asacol/5ASA maintenance for 20+ years, usually 3 pills 2x day. Use prednisone & Rowasa for flares. 
August 2008 sought care of naturopathic doctor. Tested gluten intolerant and started gluten-free diet, also none of the other foods tested sensitive to (cow's milk, soy, tomato, egg white, others)
Achieved remission for the first time in many, many years! 
Replete probiotic. Slow-release iron and B-12 shots for anemia.
 


JewelsOK
Regular Member


Date Joined Jun 2007
Total Posts : 364
   Posted 10/2/2008 2:57 PM (GMT -6)   
My son had staph aureus show up in his stool samples when he was first dx with UC. Doctor was quite surprised that it showed up that way. He was treated with Flagyl in addition to other IBD meds. I wonder if there is a link?
Julie

Mom of Son 17 UC dx 07/02, Sulfasalazine, Imuran, folic acid, L. Reuteri, Zyrtec, Iron, Vit/Min

Daughter 9 UC dx 08/07 Colazal, 6MP, Iron, Vit/Min., Culturelle

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