Imuran Side Effects

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Regular Member

Date Joined May 2006
Total Posts : 21
   Posted 10/2/2008 12:19 AM (GMT -6)   
Hey everyone! I've gladly been in remission from my UC since March '06 and have continued to take Salofalk and 175mg of Imuran daily. I've been a little concerned with how I've felt while taking the Imuran however. I constantly feel like I have this brain fog where it's difficult for me to focus and feel alert. I take the Imuran at night time and wake up in the morning ALWAYS wanting more sleep despite getting 8 hours. I usually remain tired and dizzy throughout the day and get crazy dry mouth as well. I notice this especially a couple hours after I take my Imuran dose and feel like I have unquenchable thirst. Usually on days where I've missed a dose, I've noticed this has improved a little. I've told my docs about this but they just tell me how my blood work is perfect right across the board and that the usual side effects of Imuran have to do more with nausea and vomitting. I was just wondering if anyone else has been on a similar doseage of Imuran and has had to deal with similar side effects. Thanks a bunch!

Regular Member

Date Joined Jul 2008
Total Posts : 24
   Posted 10/2/2008 6:22 AM (GMT -6)   
When I took Imuran, I felt tired also. I could get 8 hours of sleep and still feel tired. I took it in the morning though; maybe it would have helped if I took it at night. I never got the dry mouth or dizziness though. Now that I'm off of it, I feel less tired. I got 7 hours of sleep yesterday and felt okay.
Ken, 24 years old

Seborrheic Dermatitis diagnosed Jul 08 (flaring) - Fluocinonide Topical QHS, Ketoconazole 2% Shampoo TIW
Left Sided Ulcerative Colitis diagnosed Jan 08 (flaring) - 50mg Azathioprine QD, 4 x 1.2g Lialda QD, 5mg Prednisone QD, 1000mg Canasa QHS
Minimal Change Disease diagnosed Feb 06 (in remission) - 10mg Lipitor QD

1200mg Fish Oil BID, 400 IU Vitamin D + 600mg Calcium BID, 2mg Garlic Oil QD, 500mcg Biotin, 150mg Oil of Oregano, 4 x 3g Metamucil Fiber Capsules QD, 2 x VSL#3 Capsules QID, Culturelle HS QW, Nature's Way Primadophilus Reuteri QD

Veteran Member

Date Joined Mar 2007
Total Posts : 2832
   Posted 10/2/2008 7:10 AM (GMT -6)   
Ditto for me even when normal blood tests- fatigue and brain fog. It hasn't noticably affected my UC either, even at higher doses. The other side effect I'd get was occasional bursitis in the elbow and shoulders.
Pancolitis 20 years ago, full med-free remission 10 years,
Flaring or simmering on and off ever since
10 20 17.5 15 12.5 10 mg 8 7.5 20 mg pred, 100 mg Imuran
Probiotics (Primal Defense and others), TSO, hookworm
Turmeric/circumin, boswellia, fish oil, many vits/minerals
Lower-carb version of Specific Carb Diet (SCD)

Regular Member

Date Joined Apr 2008
Total Posts : 191
   Posted 10/2/2008 7:34 AM (GMT -6)   
Hi there just like to say, I'm getting the same effects as you, I'm on 150mg a day, I also got fobbed off with the fact that my blood results were ok,and that all my symptoms were a result of the UC rather than the Imuran
which perhaps is true but dos'ent help much, I've also got a bit depressed,because I hav'ent had the energy to enjoy my chrildren like I used and this seems to be as go as it's going to get for me at the momment
Anyway hang in there,and don't give up hope that a better treatment may come along.

Regular Member

Date Joined Jan 2006
Total Posts : 211
   Posted 10/3/2008 10:17 AM (GMT -6)   
I've been taking 125mg of Imuran for over 3 years and the brain fog and fatigue in the morning are my biggest side effects too, as well as a horrible memory!  Imuran works perfectly for me so I'm more than happy to take it.
Diagosed Oct 26-04 with UC
Currently in remission (since July-05)
Taking 125mg of Imuran daily (since July-05)

Regular Member

Date Joined May 2007
Total Posts : 169
   Posted 10/3/2008 10:58 AM (GMT -6)   
I have increased fatigue with Imuran (200 mg.) I just asked my GI today about it and he asked me if I were depressed. I don't think I am. He didn't seem to think it was the meds, but said to keep an eye on it. My bloodwork is always fine, too. But I can handle it; it is better than a flare.
UC diagnosed Dec. 2006
Azathioprine 200mg/day
Multivitamin, fish oil, fiber supplement, Nature's Way Primadophilus Optima, Digestive Advantage Crohn's & Colitis

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