Hi..constipation is a symptom of low in the rectum inflammation. Sometimes if it's constant, it can be recognised earlier and rectal meds increased.
I don't know what the theraputic dosage of sulfasalazine is...but higher doesn't necessarily mean lowering of symptoms if some of them are med induced.
The rectal meds are something that we don't like to use, but necessary "evil" considering UC starts at the rectum and it will always be inflamed no matter how high the extent of an individual's disease.
Pills won't reach that area or be able to treat it totally.
*Heather* Status..Asacol 6 (3 twice daily); enemas every 4th night
~diagnosed January 1989 UC (proctosigmoiditis)
~Bentylol (dicyclomine) 20mg as needed
~Probiotic 4(Natural Factors Protec) bedtime + Primadophilus Reuteri Pearls occasionally
~multi-digestive enzymes as needed
~Ranitidine,Pariet (reflux); Effexor XR 75mg(depression); Pulmicort/Airomir (asthma)
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS" worth it !!!