Experiences with Azathioprine

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Hopefull37
New Member


Date Joined Oct 2008
Total Posts : 7
   Posted 10/9/2008 8:01 PM (GMT -6)   
Hi,
 
I was recently hospitalized for the first time due to complications from UC.  Specifically, I was slightly anemic and dehydrated due to the bloody diarrea. Whenever I have flare ups they are accompanied by lower back pain that makes it difficult to stand...for this I was given MORPHINE.   My doctor has me on a prednisone taper (40 x 7, 30 x 7 etc) and colazal 9 a day along with a hydrocortisone foam (10 % or approx. 90 mg).  Since I left the hospital I have seen positive results from the prednisone (bleeding is subsiding) BUT my doctor has suggested (and prescribed) azathioprine. I am TERRIFIED of taking this medication...In two weeks I have a follow up appointment just to make sure that it ( the azathioprine) isn't killing me.  Is anyone else taking this drug and if so what has your experience been like?  Do you get sick often due to the effects on your immune system?  I've been reading up on bacterio therapy (probiotic fecal infusion) and am considering going to Sydney (my disease is confined to the lower left side of my colon and rectum and I think that I may be a good candidate for this treatment IF Ulcerative Colitis is indeed an immiunological response to an upset balance of gut flora.   I'm 26 years old and have been in and out of remission for about two years (diagnosed in January, 2007).
 
Thank You,

Probiotic
Veteran Member


Date Joined Mar 2007
Total Posts : 2832
   Posted 10/9/2008 8:23 PM (GMT -6)   
Hi Hopefull-- hey, keep us informed on the fecal bacteriotherapy. I have printed out and kept all the articles on it, such as those on Bardody's instute's website, and I ponder even trying to do it myself (minus the antibiotic regimen), since mixing feces and saline and getitng a bunch of enemas wouldn't be all that complicated. Of course, this therapy is based entirely on a couple of small studies with a dozen or so people, so it may have been a fluke- but it sounds harmless enough, if one gets the donor (ideally a spouse, sibling or someone similar whose history you know)'s stool and blood tested for infections. Heck, it is on my "must try" list before resorting to surgery, so that if I do it it wil be without any 'what if' thoughts.
Pancolitis 20 years ago, full med-free remission 10 years,
Flaring or simmering on and off ever since
10 20 17.5 15 12.5 10 mg 8 7.5 20 mg pred, 100 mg Imuran
Probiotics (Primal Defense and others), TSO, hookworm
Turmeric/circumin, boswellia, fish oil, many vits/minerals
Lower-carb version of Specific Carb Diet (SCD)
 
 
 


Hopefull37
New Member


Date Joined Oct 2008
Total Posts : 7
   Posted 10/9/2008 8:45 PM (GMT -6)   
One thing that I've also discovered is that there is a possible link between Ulcerative Colitis and an antibiotic called Levaquin. Levaquin can potentially destroy normal gut flora... around the time preceeding my initial symptoms of UC, I was taking levaquin but it never crossed my mind that this could have something to do with my digestive problems. I'm going to continue to research the bacteriotherapy and will keep you posted on what I decide to do.
Prednisone 40 Mg
Colazal 9x daily
10% Cortifoam
Symptoms Improving


rob_uk
Regular Member


Date Joined Jul 2007
Total Posts : 32
   Posted 10/10/2008 4:26 AM (GMT -6)   

hi, i've been taking azathioprine for 12 years now and i've had no problems with it.

 i had to have bloodtests every week at first, then every month, now every three months. so if anything was going wrong they would soon know about it.

i dont seem to get sick any more than anyone else.

make sure you have a flu vaccination every year though


Sweetie31105
Veteran Member


Date Joined Aug 2008
Total Posts : 903
   Posted 10/10/2008 8:47 AM (GMT -6)   
I've been taking asathiprtine (Imuran) for about a year and a half. Get my blood drawn once a month for doctor monitoring. Been fine. It keeps the ulcers away. I've been very healthy, I work in child care, and suprised that I'm not sicker than before I got this disease.
26 year old, Married, Female.
Diagnosed with UC since March 2007
Taking Humira and Imuran since May 2007 (Currently in remission since May 2007)


cycling_sasquatch
Regular Member


Date Joined May 2007
Total Posts : 169
   Posted 10/10/2008 9:14 AM (GMT -6)   
I've been on it for over a year now. Feeling good (once it started working, which takes a while, and got the dosing correct.) Never sick.
UC diagnosed Dec. 2006
Azathioprine 200mg/day
Multivitamin, fish oil, fiber supplement, Nature's Way Primadophilus Optima, Digestive Advantage Crohn's & Colitis


Beth75
Veteran Member


Date Joined Jul 2007
Total Posts : 2148
   Posted 10/10/2008 9:29 AM (GMT -6)   
Hi Hopeful, I was scared too! My stomach did not feel very well the first few weeks taking aza but after that was ok. I had problems being tired too, still do I take it at night and go to bed around 8:30-9pm during the work week.

Hope it works out well for you!
Beth, 33 ~ hoping to taper pred successfully, wish me luck!
Major Flare Sept/Oct 07
UC dx'd 03/00 (Proctosigmoiditis); Pancolitis since 09/07
Azathioprine 200mg 1xday nightly; Calcium and Vit D 500mg 3xday, Multi Vit, Folic Acid 400mg 2xday, Prilosec, Probiotics.
Minimal Change Disease (Kidney Disorder) dx'd 09/07. Close to remission since 9/08.
Prednisone 5mg/2.5mg alt days 1xday, Simvastatin 20mg 1xday, Diovan 160mg 2xday. Tekturna 300mg 1xday, Fosomax 70mg 1xweek. MCD may be from hypersensitivty to 5ASA drugs.  Do you have edema? If so, check your blood protien level!
 


Dr-A
Veteran Member


Date Joined Jul 2006
Total Posts : 2105
   Posted 10/10/2008 1:45 PM (GMT -6)   
I'll be giving that fecal transfusion a shot as soon as my newborns poos get established. Doesn't seem to hard from reading the studies, but like you said I think I'll skip the antibiotics. I was making my own probiotic enemas pretty easily with capsules... this will be much cheaper and more effective.
Proctitis DX 1999, Pancolitis DX 2008
Lialda 3 day
Immuran
Vitamin E Enemas as needed
Probiotis/GreenTea/VitD+Ca/SuperDHA


mh53mike
Regular Member


Date Joined Aug 2008
Total Posts : 149
   Posted 10/10/2008 2:01 PM (GMT -6)   
I have been on azathioprine for almost a year now and havent gotten sick at all.
26y old male medically disharged USAF veteran.Diagnosed with UC (lower proctitis) in 2004.
 
Current daily treatment:                               Probiotics & supplements:
                                         50 Billion CFU's acidopholis&Bifidobacterium daily
2400mg oral asacol                                      Digestive enzymes
10mg prednisone tapering                             5grams of glutamine
75mg azathioprine                                       folic acid & calcuim with V-D
20mg Nexum                                               Whey protien  
                                                                Multivitamin
Diet:Little/no sugars, fats, carbs, caffine,sugars,yeast. Stay natural as possible.  
 
Results:1 Bowel movement in the morning no blood! Remission since 08Sept08


robray
Regular Member


Date Joined Mar 2005
Total Posts : 130
   Posted 10/10/2008 4:24 PM (GMT -6)   
I went to Dr. Borody's clinic and tried fecal bateriotherapy. Unfortunately it didn't work for me, but I still think anyone considering it should give it a shot. The interesting thing about your post is dr. Borody wanted me to go on azathioprine before trying the fecal infusions. The thinking was that I would need to stop taking 5-ASAs which are believed to have an antimicrobial affect which would kill off the good effects of the infusions. I wasn't able to go on azathiprine for 3 months prior to the infusions so I only went on 10mg of pred. I lasted about two months after the infusions with no 5-ASA drugs and then went in to a flare. I had a flare a few years ago when I stopped my 5-ASA while on SCD and it took about two months before I got really sick. So I don't think the fecal infusions did much for me. Again I still think Borody has the right idea and it may have been the fact that I wasn't on aza or maybe I just didn't get the right donor that caused my results. Maybe you should try both.
UC (Pancolitis) diagnosed in 1992. Medications: Dipentum, Pariet


Dr-A
Veteran Member


Date Joined Jul 2006
Total Posts : 2105
   Posted 10/10/2008 5:56 PM (GMT -6)   
5-asa's are antimicrobial? Thoughts on that? Never considered that one. I would have to go off the lialda for a bit.
Proctitis DX 1999, Pancolitis DX 2008
Lialda 3 day
Immuran
Vitamin E Enemas as needed
Probiotis/GreenTea/VitD+Ca/SuperDHA

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