The first reference below is in the context of a sarcoidosis infection however it does discuss several of the issues that we suffer from as we seek to taper our prednisone doses.
Medicines work on a half life. The half life of prednisone according to the article below is 4 hours so that means that over a 24 hour day it halves 6 times. So if you start with a 20mg dose in the morning so it goes 0-4=20, 5-8=10, 9-12=5, 13-16=2.5, 17-20=1.25, 21-24=.087. So you can see that over the duration of the day, the prednisone concentration in your body reduces quite significantly. I think this sort of explains Glamourgirl's recommentations.
I found that an extra but smaller dose of steroids taken after 12 hours seemed to help my symptoms. But when i asked my GI about
splitting doses I was told that it produced an effect - this might be better explained in the second reference. But this was a bit inconsistent with what happens when you are getting IV steroids in hospital, i was given 4 IV doses a day and not one big hit. The second article also says that the effect lasts from 18-36 hours. Maybe it depends on the person and doses should be more tailored to the individual.
There is a lot of literature out there about
prednisone and maybe thats part of the reason why GIs are reluctant to get into long discussions on it.
Like Vin, I am not advocating self medication but am offering some observations and ideas which you could discuss with your GI.
for tapering discussions -
or if you are into the more technical discussions http://www.medsafe.govt.nz/Profs/DataSheet/a/Apoprednisonetab.htm
49yo single dad
mesalazine 1.5g, prednisolone 15mg
tried infliximab (remicade), humira, salofalk (5-asa enema), entocort, Azathioprine, steroid emenas, abadacept