Colitis Caused by C DIFF?

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Hopefull37
New Member


Date Joined Oct 2008
Total Posts : 7
   Posted 10/11/2008 8:12 AM (GMT -6)   
I was just thinking... In one of my previous posts, I mentioned that about a month before ANY of my symptoms appeared, I was taking an antibiotic called levaquin.  After having the bloody diarrea, colonic inflammation/mucus etc and an colonoscopy, I was diagnonsed with Ulcerative Colitis in January of 2007.  I had no idea that levaquin could cause colitis, but it makes sense.    I've since then had three subsequent flares, and have requested that my doctor look into the possibility of my colitis being caused by C diff at there has not been any stool test performed.... Is a c diff infection more acute OR can it come and go in flares?  Obviously, having a two-year lasting bacterial infection opens a whole new 'can of worms' as far as treatment is concerned, but I'm going to do EVERYTHING in my power to fight this disease.  Any thoughts on this would be appreciated tremendously.
Prednisone 40 Mg
Colazal 9x daily
10% Cortifoam
Symptoms Improving


Socalsd
Regular Member


Date Joined Jul 2008
Total Posts : 100
   Posted 10/11/2008 10:19 AM (GMT -6)   
Hello,

A C diff infection is more acute. I just recovered from one and it was bad extreme urgency no solid stools and lots of blood loss. They do need a stool sample. I think if you had it you would have been hospitalized a long time ago because it gets that serious. I was in for 19 days it was cured by oral liquid vancomicin I just gave a new stool sample which took a few days and it came back negative. I think you should give a stool sample. Don't be afraid to request it from your GI. C Diff can be deadly.
Prednisone 40mg a day
Clotrimazole Troche (keeps the thrush away from the Pred.)
just started Remicaid hope it works

Just back from 19 days in hospital with 2 blood transfusions for Anemia


jujub
Forum Moderator


Date Joined Mar 2003
Total Posts : 10407
   Posted 10/11/2008 12:20 PM (GMT -6)   
C diff has been known to be mis-diagnosed as UC. That's why most GI's do stool cultures when you have a bad flare. If he hasn't already done so, I think it would be appropriate and prudent for your doc to run stool cultures to resolve your questions.
Judy
 
Moderate to severe left-sided UC (21 cm) diagnosed 2001.
Avascular necrosis in both shoulders is my "forever" gift from Entocort.
Colazal,  Remicade, Nature's Way Primadophilus Reuteri. In remission since April, 2006.
 
Co-Moderator UC Forum
Please remember to consult your health care provider when making health-related decisions.


LondonRed
Veteran Member


Date Joined Oct 2007
Total Posts : 1190
   Posted 10/11/2008 1:52 PM (GMT -6)   
My current flare started with C-Diff. My first flare started after severre anxiety and antibiotics.... there seems to be a link between stress and bowel disorders...

Diagnosis Oct 07 and then Aug 08: Inditerminate Colitis - Minor Bleeding
Medication: 1000mg Asacol Enema, 800mg Asacol Tablets x 2 a day, Digestive Advantage


beartooth
Veteran Member


Date Joined Dec 2006
Total Posts : 517
   Posted 10/11/2008 2:10 PM (GMT -6)   
People who have gotten a c diff infection are definitely prone to relapse. For most, it will happen within the first 6 months after having gotten rid of the infection. I had a relapse mild infection about 45 days after my clean bill of health. It only took one round of vanco to get rid of it, and I've been c diff free since.

C diff is also a regular bacteria found in our digestive tract, it is only a problem when it over populates. That is why cultures are so important. I had a c-scope done at the tail end of a c diff infection, and it came back with a severe UC diagnosis. Of course my colon looked horrible, it had just gone through three months of infection, plus numerous rounds of antibiotics. Over two years later, at my latest c-scope, I was downgraded to mild to moderate colitis, with lots of pseudopolyps and scarring indicating a really bad, past inflammation.

As for c diff causing UC? I don't think it causes it, but if you have a genetic tendency towards IBD, I definitely think that an infection will trigger a flare. But there are plenty of people who have gotten c diff infections and gotten over them with no residual UC diagnosis. C diff is also one adaptable son of a gun, becoming more and more resistant to antibiotics. If you are interested in more info, I can provide a few links to some good sites about c diff.

Definitely get a culture performed. I'm paranoid now, and when my flare started, I immediately thought "C diff is back, and it is seeking revenge!". A stool culture showed it was just UC. There is definitely a different feel to the c diff then there is to a UC flare. BMs have a different smell, appearance, urgency. But the only way to truly tell is to get a culture done.
Brandon
 
36 y.o. male
Diagnosed w/ moderate UC in May '06
Asacol, Florastor, VSL#3, Wellbutrin XL, Prozac, multi-vitamin, Allegra, Lialda, Colocort enema, Prednisone (trying to taper down)


kim123
Veteran Member


Date Joined Jul 2006
Total Posts : 1201
   Posted 10/11/2008 2:40 PM (GMT -6)   
Personally, I do believe that UC symptoms can be manifested from using antibiotics, among other things (...using birth control pills, exposure to moldy environments, a diet of foods contaminated with mycotoxins,...). Antibiotics will alter the bowel terrain and allow yeast to proliferate, enabling leaky gut, perforation of the colon, crossing mucous barriers, inflammation, etc. Our diet of grains and processed sugar continues the vicious cycle, as fungus thrives on these foods. For me, my UC symptoms were definitely fungus (yeast) related. I also had the stool tests done, with no indication of c-diff. My doctors gave me Flagyl anyway, and it only made me worse. It was only on my own, 8 years later, I finally figured it (fungus) all out. I think you are onto something as you realize it was after taking antibiotics that you started getting symptoms. Are you currently taking probiotics? You may want to consider that, if not.

Hopefull37
New Member


Date Joined Oct 2008
Total Posts : 7
   Posted 10/11/2008 3:02 PM (GMT -6)   
Currently, I'm not taking probiotics BUT, I'm only not doing so until after the stool tests...I want my gut flora to (hopefully) be analyzed accurately and afterwards even if they don't find anything conclusive as to whether or not my symptoms are caused by some type of bacterial infection that may trigger flares, I will start with probiotics.  C diff degrades the lining of the colon, which in my case could explain why my sympotms and flares are exacerbated whenever I drink anything acidic such as energy drinks, soda or coffee even though my GI doctor has told me that with UC these drinks shouldn't cause flare ups...
The only thing that causes me to doubt that this could be an infection is the fact that it has gone on for almost two years (with symptoms being treated successfully with steroids each time I have a flare), and statistically, a  c diff infection is acute.  I will keep everyone posted as to how the test results go.  If I am c diff positive, then what?  I've been told that colitis cause by it is actually worse...



Prednisone 40 Mg
Colazal 9x daily
10% Cortifoam
Symptoms Improving

Post Edited (Hopefull37) : 10/11/2008 3:07:30 PM (GMT-6)


Hopefull37
New Member


Date Joined Oct 2008
Total Posts : 7
   Posted 10/11/2008 3:04 PM (GMT -6)   
By the way, Thanks everyone for the responses. You all have been most helpful.
Prednisone 40 Mg
Colazal 9x daily
10% Cortifoam
Symptoms Improving


beartooth
Veteran Member


Date Joined Dec 2006
Total Posts : 517
   Posted 10/11/2008 5:18 PM (GMT -6)   

C diff is not always acute.  I'm not sure where you got the statistics that say otherwise.  Many people get it, and get over it.  When you get your stool culture, are you asking for it just to check for c diff?  Or are you asking for an analysis of what is in you?  If you are just looking for c diff, probiotics won't matter.  Either the c diff toxins will be there, or they won't.  Also, c diff doesn't respond well to prednisone.  If you are getting positive results from pred, I'd be looking for a second opinion, and maybe treating UC/Crohn's more aggressively.

Here is a great support site for chronic c diff sufferers:

http://www.cdiffsupport.com/phpBB/viewforum.php?f=4

I'd particularly take a look at the threads about probiotics, and medications.

The people who post there are usually those with antibiotic resistant strains, so it might seem skewed towards people who have had infections for years.  THEY ARE IN THE MINORITY!  But the site contains great info, and lots of up to date research.  The moderator Bobby spends a great amount of time researching and confirming information before it posted on the site.



Brandon
 
36 y.o. male
Diagnosed w/ moderate UC in May '06
Asacol, Florastor, VSL#3, Wellbutrin XL, Prozac, multi-vitamin, Allegra, Lialda, Colocort enema, Prednisone (trying to taper down)

Post Edited (beartooth) : 10/11/2008 5:29:52 PM (GMT-6)


Hopefull37
New Member


Date Joined Oct 2008
Total Posts : 7
   Posted 10/11/2008 6:00 PM (GMT -6)   
When you say c diff doesn't respond well to prednisone, are you saying that the sympotms don't usually improve?  Basically I already have been diagnosed with UC, but want the stool test just to make SURE that it isn't anything else. 
Prednisone 40 Mg
Colazal 9x daily
10% Cortifoam
Symptoms Improving


LondonRed
Veteran Member


Date Joined Oct 2007
Total Posts : 1190
   Posted 10/12/2008 5:56 AM (GMT -6)   
C- DIFF is definitely something that can cause inflammation and mimick IBD at it's onset.

Diagnosis Oct 07 and then Aug 08: Inditerminate Colitis - Minor Bleeding
Medication: 1000mg Asacol Enema, 800mg Asacol Tablets x 2 a day, Digestive Advantage


Big Dog
Regular Member


Date Joined Aug 2008
Total Posts : 62
   Posted 10/12/2008 7:44 PM (GMT -6)   
Our daughter was diagnosed with cdiff (bloody stool samples).  No UC history in our family.  She is actually much taller and more muscular than others her age so she doesn't fit the profile of the "normal" UC child.  Suspect the cdiff actually gave her the disease Ulcerative Colitis.  She wasn't on antibiotics but our dog was.  Nice, huh? 

Mother of 8 yo UC patient
20 mg prednisone daily
.5 mg prednisone daily
Asacol 6 pills daily
Lialda 3 pills daily
Prevacid
6MP generic
Purinethol brand name 6MP
Fish Oil, Probiotics, Immune System Boosters


quincy
Elite Member


Date Joined May 2003
Total Posts : 30614
   Posted 10/12/2008 10:24 PM (GMT -6)   
UC needs the trigger to set it into motion. I can't say that I didn't have c.diff as the trigger since my THEN doctor didn't do a stool sample. I didn't have one done until I saw the GI almost 3 years later.
NO c.diff or anything to attribute my symptoms except UC...ho hum...lol!

q


*Heather* Status..Asacol 6 (3 twice daily); enemas every 4th night
~diagnosed January 1989 UC (proctosigmoiditis)
~Bentylol (dicyclomine) 20mg as needed
~vitamins/minerals/supplements 
~Probiotic 4(Natural Factors Protec) bedtime + Primadophilus Reuteri Pearls occasionally
~multi-digestive enzymes as needed
~Ranitidine,Pariet (reflux);  Effexor XR 75mg(depression);  Pulmicort/Airomir (asthma)
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS"  worth it !!!
 

Post Edited (quincy) : 10/12/2008 11:20:56 PM (GMT-6)


beartooth
Veteran Member


Date Joined Dec 2006
Total Posts : 517
   Posted 10/12/2008 11:10 PM (GMT -6)   
I will agree with Heather. While I had had some minor sypmtoms of UC prior to my c diff, it was not until the c diff that triggered the UC "flare". My initial flare was controlled almost instantly by Asacol, so it wasn't until I stopped the Asacol in June that I had my first flare. While no one in my family has a history of UC, my father was dxed with prigmoidist(?) after my UC came about. I also have a sister with undiagnosed IBS, but I don't think either of them has had the "trigger", and by God's grace, they won't.
Brandon
 
36 y.o. male
Diagnosed w/ moderate UC in May '06
Asacol, Florastor, VSL#3, Wellbutrin XL, Prozac, multi-vitamin, Allegra, Lialda, Colocort enema, Prednisone (trying to taper down)


quincy
Elite Member


Date Joined May 2003
Total Posts : 30614
   Posted 10/12/2008 11:23 PM (GMT -6)   
are you thinking proctosigmoiditis? if so, the 'itis' part means inflammation...i'm assuming of an underermined reason?

sounds classic UC, and if he doesn't have bleeding, it could be early stages.

Was your dad put on any meds?

quincy
*Heather* Status..Asacol 6 (3 twice daily); enemas every 4th night
~diagnosed January 1989 UC (proctosigmoiditis)
~Bentylol (dicyclomine) 20mg as needed
~vitamins/minerals/supplements 
~Probiotic 4(Natural Factors Protec) bedtime + Primadophilus Reuteri Pearls occasionally
~multi-digestive enzymes as needed
~Ranitidine,Pariet (reflux);  Effexor XR 75mg(depression);  Pulmicort/Airomir (asthma)
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS"  worth it !!!
 

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