5mg Prednisone... does it do anything?

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Regular Member

Date Joined Aug 2008
Total Posts : 56
   Posted 10/12/2008 6:52 AM (GMT -6)   
I am tapering my pred. pretty well but when i dropped from 10 to 5 i started not feeling so good. When we drop to the low dose of 5mg does it even do anything?
22 years old
Diagnosed with UC June 2005 at age 19
Just graduated from Virginia Tech

Have taken:
Cortifoam, Sulfasalazine, Cipro, Flagyl, Codine, Hydrocodone, Roxicodone, Canasa, Aloe Vera Juice

Asacol, Dicyclomine, Prednisone,Zoloft, Probiotics, Flintstones Vitamins with Iron

New Member

Date Joined Oct 2008
Total Posts : 17
   Posted 10/12/2008 7:33 AM (GMT -6)   
Hi! I have Crohn's Disease but have been on 5mg Prednisolone for around 6-7 years now. It seems to stop me from have any major flare ups as it maintains inflammation. You also have minimal side effects at this level and most doctors think it is a fairly 'safe level'. As I don't suffer from UC you should still check with your specialist /doctor for the correct dosage for your particular symptoms. If I drop my prednisolone all together, my Crohn's flare ups return so it definately does have some effect but it can be different for everyone to determine the most effective dosage.
I wish you well :)

35 years old
Diagnosed with CD 1988 at age 17.
Prednisone (5mg), Azathioprine (200mg) and Pariet.

Regular Member

Date Joined Jan 2006
Total Posts : 312
   Posted 10/12/2008 8:53 PM (GMT -6)   
Samynic said...
I am tapering my pred. pretty well but when i dropped from 10 to 5 i started not feeling so good. When we drop to the low dose of 5mg does it even do anything?

Explain not feeling good.  Not feeling good as in colitis symptoms coming back, or not feeling good as in going through withdrawal symptoms?
I was on pred for about a year, and at the point I got under 10 mg, i had to cut 1 mg every 2 weeks because my adrenal glands were completely hammered.  I had tried to do a 10 to a 5 to a 0 cut, but i think i almost killed myself doing it, i had never ever felt so sick in my life.  and there was no colitis at all.  So i re-stablized at 10 mg and cut 1 mg every 2 weeks until I was off.  I still went through the sick feeling for a few days to a week, but after the first week I would stabalize and feel ok again, and then I would cut another 1 mg. 
Once you get to around 7 mg of pred and u've been on it for a while, your body has a hard time adjusting because your body naturally makes 7.5 mg of pred.   Each 1 mg you take away from that point on, is what your body has to re-learn how to make. 
Pred is a nasty drug, and even at 1 mg is it still doing something in your body.  Its replacing 1 mg of the 7( thats what, 15% of your natural functions?) that your body makes normally.  so at 5 mg, thats about 80% that your body isn't using naturally and relying on artificial cortisol.
It is dangerous to be on pred for long periods of time so you will have to come off of it.   If your colitis keeps coming back as you lower your pred dosages, you are going to need either a stronger drug with less side effects(6mp, imuran, remicade, humira) or surgery.

UC since age 22, now 27.  Several huge flares since then.
Currently tapering prednisone(35 mg from 80 mg).  Also just starting 6mp again and lialda.   I definately am not liking these drugs.  Maybe surgery one day?

Post Edited (Vin) : 10/12/2008 7:56:35 PM (GMT-6)

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