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Regular Member

Date Joined Jun 2008
Total Posts : 80
   Posted 10/14/2008 12:06 PM (GMT -6)   
Hi everyone, my GI wants to try using Methotrexate as an extra therapy to try and get me in total remission...80% there, but lingering with 7 doses of remicade.  We tried 6 mp but my toxicity levels went too high and we had to stop.  I was searching for any other UC'ers that might have tried Methotrextae to know what to expect.  He says the side effects are minimal.  Intolerant to all 5 ASA's so that option is out.  He was talking about 25 mg injectibles once a week.  Anyone have any success with this drug?  Thanks in advance for the responses.

Veteran Member

Date Joined Jul 2007
Total Posts : 2148
   Posted 10/14/2008 1:31 PM (GMT -6)   
hi Landcruiser, i'm not going to be of much help but I go to a boad for my kindey's where ppl have used methotrexate with a lot of success. there a quite a few of the same meds used for that and my UC.

please let us know how it goes.
Beth, 33 ~ hoping to taper pred successfully, wish me luck!
Major Flare Sept/Oct 07.  Flare May 08 (from aspirin?).
UC dx'd 03/00 Proctosigmoiditis; Pancolitis since 09/07
Azathioprine 200mg 1xday nightly; Calcium and Vit D 500mg 3xday, Multi Vit, Folic Acid 400mg 2xday, Prilosec, Probiotics.
Minimal Change Disease (Kidney Disorder) dx'd 09/07. Close to remission since 9/08.
Prednisone 5mg/2.5mg alt days 1xday, Simvastatin 20mg 1xday, Diovan 160mg 2xday. Tekturna 300mg 1xday, Fosomax 70mg 1xweek. MCD may be from hypersensitivty to 5ASA drugs.  Do you have edema? If so, check your blood protien level!

Regular Member

Date Joined Feb 2005
Total Posts : 369
   Posted 10/14/2008 1:46 PM (GMT -6)   
I used MTX years before my UC dx for a missed miscarrage. I had two doses and had minimal nausea after each dose but no other side effects. I was told then that it would also help with my severe arthritis pain, which i never really noticed a difference there. Sorry i can't be of more help.
2003, dx moderate UC
2000, dx selective IGA deficiency w/ anti IGA antibodies
2000, dx Antipholipid Antibody Syndrome
1999-current, chronic hemmoragic ovarian cysts, w/ partial ovary removal
1977, complete reconstruction of foot after lawnmower accident (chronic pain)
6mp 75mg, prednisone 40mg (just starting meds again)
percocet 5mg 3x day
potassium 3x day

Regular Member

Date Joined Sep 2005
Total Posts : 210
   Posted 10/14/2008 3:58 PM (GMT -6)   
I took the shots for about 6 months. I had no side effects. Now I take a methortrexate tablets 3 times a week.
Lialda 3 tablets  daily
Remicade every 8 weeks
Folid Acid daily
Methotrexate 3 times a week
Align Probiotic

Regular Member

Date Joined Jun 2008
Total Posts : 80
   Posted 10/14/2008 5:32 PM (GMT -6) you think it is helping you?  did you take it from the start witht the remi?  are you in remission?  if so how long did it take?

Regular Member

Date Joined May 2008
Total Posts : 91
   Posted 10/14/2008 5:43 PM (GMT -6)   
Hey landcruiser =)
Im taking a methotrexate shot once a week-25mg. Its the highest dose they'll let you have but unfortunately for me my disease was so severe nothings working the way it should. I tried Remi-had 3 infusions-it stopped the blood in my BMs so thats a plus. The methotrexate makes me nauseated the day after. I get my shot in the top of my arm (too chicken to do it my thigh or stomach haha) on a Saturday usually in the evening or at night. For nausea, Zofran works amazingly! haha They also gave me phenegren but it knocks me out ..makes me EXTREMELY tired but it also helps with the nausea. I started out on 17mg injections and went up to 25mg of Methotrexate. Good luck with the Methotrexate. A lot of ppl have success with it =)
Katrina,17,SENIOR in high school =)
Current Meds:Methotrexate shot,Iron,Folic Acid,20mg Prednisone,Probiotic,Multivitamin,Calcium
Ileostomy step 1of2 on Nov.19

Veteran Member

Date Joined Sep 2007
Total Posts : 955
   Posted 10/14/2008 7:04 PM (GMT -6)   
i was on methotrexate in october 2006 for my psoriasis.   during my taking of it, i got the worst flare of UC in my life.  very painful and bloody and lasted a year and a half.
i dont know if that is what caused it or not, but im now afraid of it.
got rid of my psoriasis like a charm.  fabulous!
cant drink alcohol while taking it.  but other than that, dont remember any other side effects.
steph - 32 - female - UC since 2000
oh so close to remission... 5 days i am, 2 days not so sure, 5 days i am, 2 days....
Blood and D are gone, with only 1-2 bms a day! woot!
mesalazine granules 3g x1 a day (much nicer than a million tablets a day)
enteric coated fish oil -omega 3 (so they get all the way to my colon)
vitamin D3 x1 a day
prednisolone 25mg x1 a day (ick ick and did i say ick?) all done
tumeric capsules x3 a day
i eat what i want, when i want, and i get better every day!

Regular Member

Date Joined Apr 2008
Total Posts : 55
   Posted 10/14/2008 8:44 PM (GMT -6)   
I took it for a tubal pregnancy, two injections, I don't know the doses. I wasn't flaring at the time. I didn't have any side effects. Sorry I couldn't help more.
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