I had a similiar experience, but not with Zoloft. After I quit smoking last year (which lead to a flare of UC - it always did ...), I suffered from depression and anxiety due to smoking cessation. My doctor gave me Celexa and I too felt it was the best than sliced bread. When I started it, my flare was almost completely gone. I took Celexa for 6 months and then I was fine.
Around 4 weeks ago - at the height of my worst flare ever -, I wanted to start Celexa again, because I was so depressed and anxious about my flare and all that comes with the UC. Within three days my flare got even worse and I don't think it was a coincidence. I went from 15 bloody BM to 30+ BM. So I quit the Celexa again and I am scared of taking it ever again.
All SSRIs carry the risks for GI bleedings, but I have never ever thought it can make a flare worse? Seems to be true though.
Pancolitis since 3/1997
Worst flare of my life since 8/2008
Meds (as in 10/2008)
12 x Asacol a day
40 mg Prednisone
Align (just started)
Flintstones Complete Vitamins (just started - tummy doesn't like the "adult" vitamins)