How long for Predisone to start working?

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Regular Member

Date Joined Jul 2008
Total Posts : 35
   Posted 11/15/2008 12:20 PM (GMT -6)   
Hi.  I am currently on 9 colazal/ day and rowasa nightly (10 months).  My doctor just put me on 40 mg of Predisone and it has been five days w/ no relief.  Is this normal?  I thought for sure that I would see some relief by now?  Please help!  I go to see my doctor in two weeks.

Current Meds:
4 Lialda daily
Rowasa nightly

Regular Member

Date Joined Apr 2008
Total Posts : 460
   Posted 11/15/2008 2:06 PM (GMT -6)   
Prednisone always works within a few days for me. Within those first few days, I start seeing a relief in my symptoms. I hope it kicks in for you soon!!
Female, Age 37
Diagnosed w/c.diff 7/02 when pregnant w/1st and only child during 2nd trimester(wasn't on antibiotics)
C.diff flare within weeks of delivering baby 1/03
Diagnosed with UC 2/03
Current Meds:
75mg 6-MP
Cortenema as needed
Ferrex Forte
Sacchromyces Boulardii 

Regular Member

Date Joined Jul 2008
Total Posts : 100
   Posted 11/15/2008 2:26 PM (GMT -6)   
40mg is what allot of Gi's use to get people under control. It should kick in soon. I hope you see results soon.
Prednisone 20mg a day
Remicaid (3 treatments so far)
Vitamin C, Omega 3 and Slow Fe (Iron)
Metamucil wafers

34 year old male Southern California

Regular Member

Date Joined Aug 2005
Total Posts : 188
   Posted 11/15/2008 5:21 PM (GMT -6)   
It varies with people. I hope it will kick in soon for you. For me it worked within 2 days.

Suffered for my whole life before being diagnosed.

Told to "Eat more fibre "

Currently on:

1500mg x 4/day
Entocort 6mg once a day Completely off as of 10/21/08. Took 2 years!
Imuran 150mg once a day

Regular Member

Date Joined Jul 2008
Total Posts : 94
   Posted 11/15/2008 6:02 PM (GMT -6)   
I found that prednisone seems to kick in witihn 24-48 hours for me.  Maybe the dose isn't high enough for you.  Hope your doctor will have some advice for you and you find relief soon.

Diagnosed with UC 3/2008
10mg Prednisone
75mg 6-MP
Calcium + Vit D
Entocort 9mg daily
800mg Asacol 3X daily

Regular Member

Date Joined Oct 2008
Total Posts : 192
   Posted 11/15/2008 6:03 PM (GMT -6)   
When I started on Prednisone (also at 40 mg), I was wondering the same since I had no signs of improvement on the fifth day. It actually kicked in for me at the seventh day of 40 mg. I took 40 mg for 9 days and then tapered down at 5 mg incrediments every 5 to 7 days. I am at 10 mg right now. I wouldn't say I am in remission yet - I am having my period now and major problems regarding the UC smhair -, but I haven't seen any blood in 10 days, no more night time BMs and total BM are 2- 4 a day (seeing that now from having 30+ BMs a day is definitely a huge improvement), but I hope I am getting there and life is livable again.
I am sure you will see and feel improvements soon, too. Hang in there - I know, it is the dreaded prednisone. Just take the lowest dose that works for you for the shortest amount of time (that is what my doctor says) necessary. And by the way, I had the most improvements while being on 25 mg for a week.
Hope you feel better soon!
Pancolitis since 3/1997
Worst flare of my life since 8/2008, finally showing improvement!!
Meds (as in 11/2008)
12 x Asacol a day
40 30 25 20 mg Prednisone
Flintstones Complete Vitamins

Regular Member

Date Joined Jan 2005
Total Posts : 352
   Posted 11/15/2008 9:48 PM (GMT -6)   
I recall it worked in 4 days but I was taking 60 mg a day and my symptoms were not as severe as yours.  I greatly dislike pred, but it was successful for me, so I would ask the doc if your dosage should be higher.  Docs always like when you tell them how to do their jobs.   Not....
But, that's what I would do.  My GI doc is actually more open minded than my other docs.
Mild to Moderate Left Side UC since 10/2002, Joint Pain since 10/2004
Strict SCD 7/2004-12/2005
Prednisone 8/2004-10/2004
Remission since 9/2004
Daily Meds:
 1500 mg Pentasa, 150 mg Zoloft, 30 mg Baclofen, 10 mg Ambien

New Member

Date Joined Nov 2008
Total Posts : 4
   Posted 11/16/2008 11:43 AM (GMT -6)   
It never worked for me and I was on it for months. All I got were side effects.
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