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Giorgio
New Member


Date Joined Apr 2007
Total Posts : 14
   Posted 11/18/2008 8:24 PM (GMT -6)   
Anyone has info on MLN-02 ? well, I am in South East Asia, the drug does not have a name yet!
Dignosed March 2006.
Daily Prednisolone 5mg*3 ; Imuran 50mg *3 ; Salofalk 500mg *4 .
 


sadgirl1984
Regular Member


Date Joined Aug 2008
Total Posts : 55
   Posted 11/19/2008 12:10 AM (GMT -6)   
never heard of that

quincy
Elite Member


Date Joined May 2003
Total Posts : 30596
   Posted 11/19/2008 2:39 AM (GMT -6)   
what is the actual drug that's being used in MLN-02? MesaLamiNe?

Where did you find out about it? Any information on it...??
Please add more to the enquiry.

q
*Heather* Status..Asacol 6 (3 twice daily); enemas every 4th night
~diagnosed January 1989 UC (proctosigmoiditis)
~Bentylol (dicyclomine) 20mg as needed
~vitamins/minerals/supplements 
~Probiotics....(Natural Factors Protec 2 or 3  +   1 or 2 Primadophilus Reuteri Pearls @ bedtime
~multi-digestive enzymes as needed
~Ranitidine,Pariet (reflux);  Effexor XR 75mg(depression);  Pulmicort/Airomir (asthma)
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS"  worth it !!!
 


Giorgio
New Member


Date Joined Apr 2007
Total Posts : 14
   Posted 11/24/2008 1:55 AM (GMT -6)   

Extractions from web:----

Over the short term, steroid drugs like prednisone work well to fend off the bloody diarrhea, cramps, and fatigue of ulcerative colitis, a disease that causes inflammation and ulcers in the colon. But the drugs can cause severe side effects if patients take them for long periods. Canadian researchers wondered if MLN02, a drug that blocks immune-system cells from inappropriately attacking the lining of the colon, could ease the symptoms of ulcerative colitis without the side effects of steroid drugs.

What the researchers wanted to know: Can the drug MLN02 ease symptoms of ulcerative colitis?

What they did: Researchers used blood tests, stool samples, questionnaires, and colonoscopies to determine the severity of disease in 181 ulcerative colitis patients. They then divided the patients into three groups. Patients in two groups, a high-dose group and a low-dose group, each received two intravenous doses of MLN02 one month apart. The third group received a placebo. Researchers examined all the patients several times over the six-week experiment.

What they found: After six weeks, roughly a third of the patients who took MLN02, regardless of dosage, went into remission, compared with only 14 percent of the patients in the placebo group. Sixty-six percent of the patients in the low-dosage group and 53 percent of those in the high-dose group showed improvement of symptoms, while only 33 percent of the placebo group patients improved. When researchers checked the severity of the disease in a colonoscopy, 28 percent of patients who received the smaller dosage of medication showed significant signs of remission, compared with 18 percent in the high-dosage group and only 8 percent in the placebo group. (At this point, it's not known why low-dose patients did slightly better than high-dose patients.) One patient developed hives and mild swelling during her second treatment with MLN02, but researchers did not find other serious side effects.

What this study means to you: Short of a surgical procedure to remove parts of the colon affected by ulcerative colitis, researchers have not yet found a cure for this chronic disease. But with a drug like MLN02, doctors now have another treatment option. Unlike steroid drugs, which mimic hormones in the body and work within the cell, MLN02 blocks proteins on the cell surface to prevent attacks by white blood cells. Such a drug could reduce doctors' dependence on steroids, which can cause severe side effects if patients take them for a long time


Dignosed March 2006.
Daily Prednisolone 5mg*3 ; Imuran 50mg *3 ; Salofalk 500mg *4 .
 


Probiotic
Veteran Member


Date Joined Mar 2007
Total Posts : 2832
   Posted 11/24/2008 6:41 AM (GMT -6)   
I hadn't heard about this drug before... sounds like a new biologic still in trials? I googled and this popped up but it's from 2006... http://www.medscape.com/viewarticle/528320_20
Pancolitis 20 years ago, full med-free remission 10 years,
Flaring/simmering on and off ever since, allergic to all 5ASAs
10 20 17.5 15 12.5 10 mg 8 7.5 20 17.5 mg pred, 100 mg Imuran
TCM, Probiotics (Primal Defense and others), DMSO, TSO, hookworm
Turmeric/circuminboswellia, fish oil, many vits/minerals
Lower-carb version of Specific Carb Diet (SCD), Remicade newbie
 
 
 

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