I have used Cyclosporine twice for severe UC flares.... make sure the GI that you are using is experienced with Cyclosporine; it's not one of those drugs that you just want to "try" but it is very safe if properly monitored by an experienced GI. Each time that I used Cyclosporine it required a lengthy hospital stay.
It is a very effective drug for treating a UC flare; I noticed significant improvements in about 4 days of being on IV Cyclosporine. And not too many horrible side effects either.
I would suggest that weigh everything out before starting Cyclosporine; also consider surgery. Remember that between 25%-35% of UC patients require colon surgery at some point in their life.
DX'd with Pan-Colitis June 2005
Current Status: Remission
Current Meds: 50 mgs 6-mp
Supplements: Forvia multi-vitamin