Sometimes it takes up to five infusions for Remicade to work properly.
I wasn't having much improvement after my 3rd Remicade infusion either, but my c-scope showed that only a few centimeters of inflammation was left, so I canceled surgery. And so I tried different combos of rectal meds. My 4th infusion and alternating between Canasa and Anucort (steroid suppository) helped me dramatically.
Rifaximin only helps about half of the UC patients. It made things much worse for me, but it could be worth a try.
Female, Age 20
9 Asacol, Rowasa, 1000 mg Canasa, Proctofoam, Rifaximin 2/day
Digestive Advantage (Crohn's & Colitis), 1 Florastor, 50 mg 6MP, 1 Primadophilus reuteri, Remicade (4 infusions), 2.4 g Lialda, 1 Forvia, 6 Colazal/day, 1 Anucort, Culturelle, Fish Oil, Calcium/Vit D supplement