Big Dog -
The test is called a TPMT, which will show if you have the enzyme activity to properly metabolize 6-MP. It's only done by Prometheus Lab in California. I have been taken off of 6-MP twice as it lowered my white blood cell count, and once had the dose lowered as it was becoming toxic to my liver. I was recently tested again and found that my enzyme activity is below the low end of normal, so I've recently started Remicade instead. Thankfully, that kicked in on the third day after my first infusion (I've had two so far). I've been on Prednisone for two years and every time I taper to the lower doses (5 or 2.5), I flare again. I won't go up again and my GI doesn't want to raise it again, either, so I'm now on Remicade and that's working. I'm tapering the Prednisone by 2.5mg about
every 7-10 days and hopefully can get off it.
Ulcerative Pancolitis (dx'd 6/2002)
Pentasa (4gm/day); Prednisone 5mg am, 5mg pm; Aranesp injection every week for anemia;
Started iron infusions 7/18/08; starting Remicade 11/12/08
6-MP (discontinued as it lowers my white count)
various meds for other conditions