High Dose Of Imuran ?

New Topic Post Reply Printable Version
[ << Previous Thread | Next Thread >> ]

festeris101
Regular Member


Date Joined Dec 2008
Total Posts : 115
   Posted 12/1/2008 7:54 PM (GMT -6)   
Hello All,
          I've just joined and this is my 1st post. I have UC and some arthritic conditions that all seem to be related and have been on 5 mg. of Prednisone and 550.mg of Imuran for almost 5 years. After reading many posts here I've noticed most people calling a high dose 200 mg. 
 
It's making me a little nervous... skull
 
Anyone here on this high a dose...Thanks!

Another UC wife
Veteran Member


Date Joined Jun 2007
Total Posts : 2111
   Posted 12/1/2008 9:03 PM (GMT -6)   
I don't know the answer to that question. My hubby was just increased to 200mg from 150. Since we incorporated the Mayo Clinic in his care which is a year now, his Dr at Mayo prescibes his Imuran (azathioprine) on a month to month basis only because he insists on monthly labs for AST, CBS, ALT (If I have my initials correct). Once he gets the lab results and reviews them his nurse phones in a month's supply of medication. We do this every month - sometimes it is a pain if the lab hasn't faxed the results I need to call them and have them re-fax it. I have a chart and make sure I allow a full week for the entire process so we won't run out of medication.

His lab work has been fine and since the UC is slow to respond to a remission is the reason he increased it to 200. My husband's weight is approx 180 lbs.

I was initially concerned about this drug which started out at 75mg (his local Dr was ultra conservative starting him on the medication to begin with) and when increased to 150mg his Dr @ Mayo assured me not to be overly concerned as he insists on the monthly monitoring to keep close tabs on it. He told me this is a "safe" medication when monitored properly. Sooooooooooooo you might want to have a little more dialogue with your Dr especially with the higher dose you are on if you have any questions and are concerned. You need to feel comfortable and assured regarding your care.

I hope and pray the trust and confidence we have with the way his care is being managed is correct. I have no problem with asking questions on his behalf so we can stay as informed as possible.

61 yr old male~Colitis 1st diagnosed Jan '05-cleared up within a few wks. Flared again in May '06 (now UC) & hospitalized 5/07-currently heading towards a remission. Osteopena of spine from prednisone DX 8/07  Oct 07 feeling quite normal most days.  150mg Imuran  Zero mg prednisone  12 Asacol, Lidocaine Hydrochloride Jelly 2%,multi vitamin, iron 1X day, DanActive, chewable calcium, fiber capsule 1x day, Prilosec 20mg, enalapril 10mg, glipizide 5 mg, zocor 20 mg, baby aspirin, (Fentanyl pain patch 50mg 72 hrs  Morphine Sulf 15 mg twice daily)Cortifoam enema every other PM, Canasa suppositiry AM, folic acid 1mg, Fosamax 1x month


Charlotte Gilman
Regular Member


Date Joined May 2008
Total Posts : 100
   Posted 12/1/2008 11:24 PM (GMT -6)   
It's used at much higher doses in transplant patients than are typical for UC. I think the highest I've seen discussed for either is about 300 mg, though. I'd definitely ask your doctor about it--have you been getting your bloodwork monitored?

SwollenColon
Regular Member


Date Joined Nov 2006
Total Posts : 190
   Posted 12/2/2008 8:36 AM (GMT -6)   
I've been on 350mg for a couple years. Bloodwork every 3 months, always comes back fine. My GI told me that over 350mg is wasted on UC patients in most circumstances. My understanding is the dosage is determined by how your body metabolises the drug, and not based on weight or anything else.

festeris101
Regular Member


Date Joined Dec 2008
Total Posts : 115
   Posted 12/2/2008 10:30 AM (GMT -6)   
In my case we worked up to the 550 mg. with 50 mg. increments until I went into a kinda remission. I've tried to dose myself down on the sly but everytime I get down to the 350 mg. mark I flare up immediately. My blood is tested every month for liver function etc. and it's beginning to get high though and they're looking into PSC.

My GI is trying to talk me into Remicade and I know it sounds foolish but the though of 3 hour long transfusions freak me out. If it was in a pill I'd probably give it a shot!

Anyway I just worry about the longterm effects of the Pred & Imuran especially where my Doctors say I'll likely be on this dosage for the rest of my life...
550 mg. - Imuran daily
     5 mg. - Pred daily
   20 mg. - Prilosec daily
   35 mg. - Fosamx weekly


Probiotic
Veteran Member


Date Joined Mar 2007
Total Posts : 2832
   Posted 12/2/2008 10:46 AM (GMT -6)   
The Remi transfusions can be two hours tops for most patients, and they are really non-events- I don't feel a thing, not even from the prick for putting the thing in my vein. You sit in an easy chair with a book, a laptop or watch a DVD and it is over before you even know it. In my case it has no adverse effect on me on the day of the infusion and knock on wood I have not felt any side effects yet. Good luck with the Imuran dosages.... I will never know if a higher dose would have helped me but it never seemd to do anything for me all the way to 150 mg. But noone checked my metabolities for optimum dosing, though I got regular bloodwork.
Pancolitis 20 years ago, full med-free remission 10 years,
Flaring/simmering on and off ever since, allergic to all 5ASAs
10 20 17.5 15 12.5 10 mg 8 7.5 20 17.5 15 mg pred, 100 mg Imuran
TCM, Probiotics (PD, Cust.Probiot., Culturelle, etc), DMSO, TSO, hookworm
Turmeric/circuminboswellia, fish oil, many vits/minerals
Lower-carb version of Specific Carb Diet (SCD), Remicade newbie
 
 
 


Big Dog
Regular Member


Date Joined Aug 2008
Total Posts : 62
   Posted 12/2/2008 11:21 AM (GMT -6)   
Wow, learned a bit from these posts - our daughter's labs show that the Imuran is working but that her toxicity levels are high. Maybe a reduction in the dosing would reflect the Imuran still working but bring those toxicity levels down. I'll have to question her Dr. The side effects she experiences are from the high toxicity levels, not the Imuran, or so we're told.
Mother of 8 yo UC child
Lialda 3 pills daily
Imuran 50mg 3x daily
Fish Oil, Probiotics, Immune System Boosters, Multi-Vit with Calcium


Charlotte Gilman
Regular Member


Date Joined May 2008
Total Posts : 100
   Posted 12/2/2008 11:23 AM (GMT -6)   
festeris101 said...
In my case we worked up to the 550 mg. with 50 mg. increments until I went into a kinda remission. I've tried to dose myself down on the sly but everytime I get down to the 350 mg. mark I flare up immediately. My blood is tested every month for liver function etc. and it's beginning to get high though and they're looking into PSC.

My GI is trying to talk me into Remicade and I know it sounds foolish but the though of 3 hour long transfusions freak me out. If it was in a pill I'd probably give it a shot!

Anyway I just worry about the longterm effects of the Pred & Imuran especially where my Doctors say I'll likely be on this dosage for the rest of my life...


The long-term effects of Imuran are way better documented than those of Remicade; it's a much older drug. I would definitely worry about the prednisone, though, and the question mark over the Remicade was too much for me to take it. Is there a reason why you're not considering surgery?

ediekristen
Veteran Member


Date Joined Apr 2007
Total Posts : 1366
   Posted 12/2/2008 12:35 PM (GMT -6)   
My doctor told me once he dosed based on weight, I'm not sure what the calculation is but I'm on 100mg and I weigh 115lbs, but weighed 130lbs when he prescribed it. At such a high dose though you should definitely be sure you don't miss any blood work appointments!

Female, 23, Ulcerative colitis (pancolitis) since 1999; GERD; gastritis; osteopenia in femur head & lumbar spine from long term prednisone use...

Current Meds:
Lexapro 10mg, Azasan 100mg

 
 

New Topic Post Reply Printable Version
Forum Information
Currently it is Sunday, June 24, 2018 1:28 AM (GMT -6)
There are a total of 2,974,661 posts in 326,195 threads.
View Active Threads


Who's Online
This forum has 161294 registered members. Please welcome our newest member, TRNS.
267 Guest(s), 2 Registered Member(s) are currently online.  Details
Kippette, JayPoppa