Hi..yes, the enemas and oral 5ASA have worked for me for 20 years.
You should stick with the enemas as best you can....
How many bms are you having during the day?
How many mezavant are you taking daily? are you taking them twice or thrice daily?
When did you start the enemas.
Yes, you have to use the enemas nightly. You went so long without meds...it'll take a while for the rectal inflammation to calm down.
One thing you could do is use the suppository during day after your morning bm(s), and use the enema at night.
You could also try to white-knuckle it through the urge to go ... it can pass .. or try to have a bm if you have the urge before you do the enema.
Make sure you stay on your left side so that it doesn't put any prssure on the area to expel it.
It takes time....pretty soon you'll improve.
It's true what glamourgirl states regarding not all UCers can take 5ASA meds...but for some, it can also seem worse before it gets better (as in my situation),
Welcome to the forum!
*Heather* Status..Asacol 6 (3 twice daily); enemas every 5th night
~diagnosed January 1989 UC (proctosigmoiditis)
~Bentylol (dicyclomine) 20mg as needed
~Probiotics....(Natural Factors Protec, Primadophilus Reuteri Pearls, Natural Factors Ultimate)....1 each @ bedtime
~various digestive enzymes as needed
~Ranitidine (reflux); Effexor XR 75mg(depression); Pulmicort/Airomir (asthma)
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS" worth it !!!