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Regular Member

Date Joined Aug 2008
Total Posts : 46
   Posted 12/15/2008 7:13 AM (GMT -6)   

I know that 6mp (like azathioprine) takes a while before it starts to kick in and have an effect, but I was just wondering how long it took to work for those who are using it, and if it very gradually started taking effect, or if the results were more sudden.

my background with this drug...
I was on azathioprine for about 5 weeks, (3 weeks 50mg, 1 week 100mg, 2 weeks 150mg (would have been my top dosage)) but then I started to have really bad intolerance to the drug. basically it caused my pancrease to swell, and I had a high temperature and was in paint and vomiting etc etc. I had 4 days off before starting 6mp. I have now been on 6 mp for 4 weeks (1 week 25mg, 1 week 50mg, 2 weeks 75mg (my final dosage)) so far I haven't had bad side effects (thank god). but I also haven't noticed any improvements from taking the drug yet.


Regular Member

Date Joined Apr 2008
Total Posts : 460
   Posted 12/15/2008 7:22 AM (GMT -6)   
It took about 3 months for it to work for me. It never put me in complete remission but it helped. I was weaning off of Prednisone during the time that I waited for it to work, so I don't know if it was the 6MP kicking in or the effects of the Prednisone.
Female, Age 37
Diagnosed w/c.diff 7/02 when pregnant w/1st and only child during 2nd trimester(wasn't on antibiotics)
C.diff flare within weeks of delivering baby 1/03
Diagnosed with UC 2/03
Current Meds:
75mg 6-MP
Cortenema as needed
Ferrex Forte
Sacchromyces Boulardii 

Forum Moderator

Date Joined Apr 2004
Total Posts : 23551
   Posted 12/15/2008 7:27 AM (GMT -6)   
At 7 weeks, which according to my GI is very fast, I literally had a switch flipped - it was like I went to bed feeling like crap and woke up with normal everything. That normal feeling lasted a little while and then I think my colon said, hey wait a minute! Things are going too good for her, lets mess her up a bit! :) Now I found that I can't metabolize it correctly and I can't get into the therapuedic (sp?) range. I am just below it. So for the most part I am in remission but I do still have these minor flares but luckily no blood. I can honestly say that I felt my best on this med around the 3-4 month mark. I have been on 6mp now for 3 years(?) I forgot how long lol.
Moderator for Allergies/Asthma and Co-moderator for UC
~Left sided Uc-'92-Colazal(9 daily),6mp(50-100mgs),Bentyl, Prilosec,Biotin,Forvia,Pro-Bio**Unable to tolerate Asacol, Rowasa or Canasa**~Year-round allergies-Singulair, Zyrtec~Secondary Reynauds Syndrome-'04-Norvasc~Sacroiliitis-epidural injections~bulging and herniated discs C5/C6 & C6/C7~3 epidural injections-worked great!, OA in my fingers 
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Regular Member

Date Joined Aug 2008
Total Posts : 46
   Posted 12/15/2008 8:15 AM (GMT -6)   
Thanks for the replies. I knew that the answers would vary, as everyone reacts differently to drugs. Its just that I have a meeting with a surgeon later today, and I wanted to know time scale to give the 6MP a decent shot before commiting to the knife.

Oh man I hope a switch flicks in me! that would make me sooo happy!


UC Mom
Regular Member

Date Joined Jun 2007
Total Posts : 146
   Posted 12/15/2008 6:45 PM (GMT -6)   
It took my son at least 6 months to be considered in remission. Hang in there, and God bless.
UC Mom
Son diagnosed 10, 2006 at age 15
6MP 100 mg. per day
Vitamin Supplements

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