UC and English descent

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Christine1946
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Date Joined Aug 2008
Total Posts : 5975
   Posted 12/20/2008 3:46 PM (GMT -6)   
     Was just wondering.......I noticed some of the people in this forum are from the UK, Canada and Australia.  I am an American but dad was English descent (but family in US since 1600's) and it is from dad's family that I inherited this nasty disease..UC.  Any studies done to link UC and the UK?
62 yr old granny. South Jersey
Diagnosed with ulcerative proctitis in 1998 in hospital
Hospitalized (2nd time) in May 2008
Update 11/03/08...finally in remission!!  Hope I don't jinx myself.  Off the prednisone since 11/01/08...now see if I can stay off for longer than two weeks.  Other meds: 6MP (75 mgm), colazal (6 per day), Benicar and Toprol (high blood pressure meds), Probiotic (2 per day), fish oil capsule and multi-vitamin and calcium with vitamin D.


theklep
Regular Member


Date Joined Nov 2007
Total Posts : 75
   Posted 12/20/2008 4:46 PM (GMT -6)   
My Grandparents are from Canada on my dads side but no history of UC to my knowledge....
Jeff, 24, Diagnosed July 2007 probably had it since 2005 but no real symptoms till July 2007 *Update 3/25/08: Entire Colon UC*
Lialda - 2.4mg 2x Day
Rowasa 1x (for spot treating and flare ups)
Centrum Multi-Vitamin 1X Day
Probiotics by Ethical Nutrients- Intestinal Care (Started Recently During a Long Flare Seems To be Working Wonders) 2x day
Probiotics by VSL #3 (trying it out at 2x a day now)
Slow Fe (Iron supplement)- 1x day
Lexipro- 2x Day 10Mg
In What I Would Call a Remission....As Close to Normal As It Gets


Ontario_Girl
Regular Member


Date Joined Dec 2008
Total Posts : 28
   Posted 12/20/2008 5:04 PM (GMT -6)   
Well, I'm English and living in Canada, and from what research I've seen, there is a deffinately link to Western, developed countries....

I think it's the human body saying 'no more' to all the processed foods, pollutants and radio waves that we subject it to here in the 'developed' world....what do you reckon??
Female
Diagnosed with UC in 2003 (aged 24)
Asacol 6-8 oral tabs daily
Pentasa Suppositories
Flora-Smart Extra Strength Probiotics
Green Tea
Attempting low gluten....but struggling! Also love too much sugar..


katkat
Regular Member


Date Joined Feb 2005
Total Posts : 239
   Posted 12/20/2008 5:42 PM (GMT -6)   

Just had to jump in here, when I saw this thread. 

I used to live in Vancouver BC, Canada and that's when this all started for me.  Probably a combination of a lot of things at that time, it was a new relationship for me, new surroundings (from small town to a big city) looking for a job, leaving my birthplace in Ontario to that.  Anyway, I usually go online to read the Vancouver Sun newspaper and there was a video about Crohn's Disease and IBD and apparently these IBD disease are more prevalent for those people that live within the 49th parallel and up. Or more appropriately northern climates.  There is a few examples on line about this as well. That's why apparently Canada at the moment is a hotbed for IBD research.  Don't know how that would affect anything, though. Strange things happen.


44 yrs old, only 3rd experience with flare-up start oct29.08, Ont.Canada. was 140lbs now 118
current: asacol 400 mg - 2 4x/day
                          
last flare in 2004 with c-diff, went into shock, hospitalized 2 wks, rec'd transfusion
prednisone, asacol, metronidazole
 
in 2000 rec'd antibiotics(sinuses),c-diff,ulcerative colitis 
 


Peety
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Date Joined Mar 2008
Total Posts : 2855
   Posted 12/20/2008 7:10 PM (GMT -6)   
I have a lot of English in my ancestry too. I also noticed a lot of Canadians and UK folks on the line.
49 year old female attorney, diagnosed UC/pancolitis 1985, no surgery but much suffering.
Asacol/5ASA 6x400 mg maintenance for 20+ years; use prednisone & Rowasa for flares. 
August 2008 sought care of naturopathic doctor. Food sensitivity test showed gluten, other intolerances; started diet without gluten, soy, dairy, tomato etc. Replete$$ probiotic powder at first, now Forte pills. Doing much better, but still having some bad days. 


Shadam
Regular Member


Date Joined Jan 2009
Total Posts : 307
   Posted 1/7/2009 9:09 PM (GMT -6)   
My mother is from the UK (no UC at all)...however I was born and raised in the USA

ucwarrior
Regular Member


Date Joined Jul 2008
Total Posts : 298
   Posted 1/7/2009 11:10 PM (GMT -6)   
I am English and German and live in America.

Most of the current legit research I have read lately concerning UC has come from Canada.
Diagnosed w/ Ulcerative Colitis in 1995
32 years old
Living med free  
Currently in remission  


Kiss520
Veteran Member


Date Joined Jun 2008
Total Posts : 742
   Posted 1/8/2009 11:36 AM (GMT -6)   
Totally agree with Ontario Girl - Western culture has the most unhealthy processed foods.  Now I know a lot of people might argue and say that they ate "healthy" and still got UC, but its nearly impossible to avoid the pollutants, pesticides and other nonsense that we unknowingly allow into our bodies. 

Katie, 30.   Chicago 'burbs.
DX:  Pancolitis as of 9/08 (Proctitis as of 1/08)
Current Treament:  Spinach/sunflower & Low-residue diet.
Previous Treatment:  Canasa suppositories, Cortifoam, Prednisone, Colazal, Symex DuoTabs, Rowasa, Bentyl, Cortenema, Asacol, Iron, Zoloft, Acidophilus.
Status:  Near total remission
 
 
 
 


quincy
Elite Member


Date Joined May 2003
Total Posts : 30986
   Posted 1/8/2009 11:37 AM (GMT -6)   
I'm Canadian..born and raised.  My paternal grandparents were from Scotland and my maternal grandparents were from Poland.
 
I have crappy genes, basically.
 
q


*Heather* Status..Asacol  (3 twice daily); flaring since Dec 22, tapered every 2nd nite (Jan 3)
~diagnosed January 1989 UC (proctosigmoiditis)
~Bentylol (dicyclomine) 20mg as needed
~vitamins/minerals/supplements 
~Probiotics....(Natural Factors Protec, Primadophilus Reuteri Pearls, Natural Factors Ultimate).... @ bedtime
~various digestive enzymes as needed
~Ranitidine (reflux);  Effexor XR 75mg(depression);  Pulmicort/Airomir (asthma)
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS"  worth it !!!
 

Post Edited (quincy) : 1/8/2009 9:56:52 AM (GMT-7)


jblue65
Regular Member


Date Joined Jan 2008
Total Posts : 381
   Posted 1/8/2009 11:51 AM (GMT -6)   
My ancestors were from Spain ( Sephardic Jews)- on my dad's side - Spanish and French. No English here.
Jackie, 43

Pancolitis, DX October 06

Lexapro, colazal 3x3, Sythroid, Protonix, Flagyl

10 infusions of Remicade- doesn't work
Severely anemic-

back up to 30 mg of pred
Added 6MP- November 25th
 
Surgery almost certain


mudua
Regular Member


Date Joined Apr 2007
Total Posts : 459
   Posted 1/8/2009 1:37 PM (GMT -6)   
UC is very common amongst Indians.

Maybe it's because British soldiers raped Indian women during rthe British rule of India

unclebubba
Veteran Member


Date Joined Dec 2008
Total Posts : 510
   Posted 1/8/2009 3:42 PM (GMT -6)   
born and raised american... family been here forever. But we are of almost pure scotish decent. With a little native american thrown in. Am first in my family diagnosed with UC, but grandparent and great grandparent all had gut problems, just never got diagnosed with it. Two great grandma's died of colon cancer.
 
38 yr old male, NE Ohio
 
diagnosed in aug 2008
30 mg predisone, 9 balsalazide, rowesa enema, 2 gemfibrozil, 1 norvasc, 1 metoprotol, 1 allopurinol, 2 probiotic, 2 aloe vera
gluten intolerance... attempting to live no/low gluten
 
**********
update: down to 25 mg pred a day as of 12/25/08
**********
update: down to 20 Mg pred a day as of 1/7/09


pb4
Elite Member


Date Joined Feb 2004
Total Posts : 20577
   Posted 1/8/2009 4:59 PM (GMT -6)   
I believe overall Canada has the highest incidence of IBD per capita...I'm Canadian and live in Alberta which for the longest time was the leading province for IBD, recently Nova Scotia has been winning that race over AB. IBD now a days is becomming more prevalent world wide though, africa, china, ect, places where it was virtually unheard of and they suspect it may have something to do with those places becomming a little more westernized especially when it comes to food.

:)
My bum is broken....there's a big crack down the middle of it! LOL :)


JM21204
Regular Member


Date Joined Dec 2008
Total Posts : 254
   Posted 1/8/2009 6:12 PM (GMT -6)   
I have some English descent; 1/8th of me. My mother has UC and is 75% Swedish/25% English - hasn't flared in 20 years or so and no medication. I got it much worse unfortunately.
33 yr old female
Diagnosed with Pancolitis in 1/2007
Baby due 3/2009
 
1600 mg Asacol a day
Ferrex
Pre-Natal Vitamins
Lovenox
On and off Prednisone, 40 mg then taper
 


Old Hat
Veteran Member


Date Joined Feb 2007
Total Posts : 5190
   Posted 1/8/2009 11:38 PM (GMT -6)   
The latest medical thinking is that IBD has something to do with Northern climes-- less exposure to sun, less vitamin D over generations leading to genetic mutation-- that kind of thing, resulting in higher rates of illness in UK, Netherlands, Iceland, Canada, for example. That's what they got from 1990s epidemiology, I think. However, higher numbers of cases reported in India, Japan, & the Philippines seem to support theories of overdevelopment involving technology, changing food supply, etc. More on this will be published in the coming year; two U.S. gastroenterologists will soon publish a book called The Changing World of IBD, which deals with genetic & environmental issues, among other subtopics. / Old Hat (nearly 30 yrs with left-sided UC ... [etc.])

quincy
Elite Member


Date Joined May 2003
Total Posts : 30986
   Posted 1/9/2009 2:21 AM (GMT -6)   
mudua said...
Maybe it's because British soldiers raped Indian women during rthe British rule of India
Probably not ! shocked
*Heather* Status..Asacol  (3 twice daily); flaring since Dec 22, tapered every 2nd nite (Jan 3)
~diagnosed January 1989 UC (proctosigmoiditis)
~Bentylol (dicyclomine) 20mg as needed
~vitamins/minerals/supplements 
~Probiotics....(Natural Factors Protec, Primadophilus Reuteri Pearls, Natural Factors Ultimate).... @ bedtime
~various digestive enzymes as needed
~Ranitidine (reflux);  Effexor XR 75mg(depression);  Pulmicort/Airomir (asthma)
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS"  worth it !!!
 


pb4
Elite Member


Date Joined Feb 2004
Total Posts : 20577
   Posted 1/9/2009 2:30 AM (GMT -6)   
Crohn's disease/UC is found throughout the world. However, it appears to be most common in North America and northern Europe, and Canada has one of the highest incidence rates in the world. Crohn's affects more than 800,000 people in North America. The highest prevalance to IBD is with those from jewish descent.


:)


My bum is broken....there's a big crack down the middle of it! LOL :)

Post Edited (pb4) : 1/9/2009 12:37:04 AM (GMT-7)


Red_34
Elite Member


Date Joined Apr 2004
Total Posts : 23551
   Posted 1/9/2009 7:36 AM (GMT -6)   
My grandfather was 100% Shiawasee Indian (American) then he married my Gma who is of Scottish, English and Swedish decent. So my mother was a mutt with mostly Indian genes. I know that on my mothers side, bowel issues are common. And I inherited those lovely bowel issues.
 @--->--SHERRY--<---@
Moderator for Allergies/Asthma and Co-moderator for UC
~Left sided Uc-'92-Colazal(9 daily),6mp(50-100mgs),Bentyl, Prilosec,Biotin,Forvia,Pro-Bio**Unable to tolerate Asacol, Rowasa or Canasa**~Year-round allergies-Singulair, Zyrtec~Secondary Reynauds Syndrome-'04-Norvasc~Sacroiliitis-epidural injections~bulging and herniated discs C5/C6 & C6/C7~3 epidural injections-worked great!, OA in my fingers 
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LeafsFan
Regular Member


Date Joined Dec 2008
Total Posts : 274
   Posted 1/9/2009 8:57 AM (GMT -6)   

I am from Canada. My father's side of the family is from out east (NFLD) and has some English and possibly scottish descent I believe. Not sure about my mom's side, all from Ontario for quite some time. Only UC in my family is my dad's Aunt, who has been in remission for years. I'm the first lucky one in my family to carry it on I guess.

I have also heard about the northern climates being affected, but there has also been studies showing how heart disease and IBD are almost non-existent in far north climates such as greenland where they eat a diet high in fish and healthy fats as opposed to processed crappy food. I think it is showing that western food is a killer.


 
Chuck - 28 yrs and counting
 
Diagnosed w/ UC Dec 08
 -----------------------------------
Pentasa 500mg 2pills-4x daily
Prednisone 50mg 45mg 40mg day - Calicium + Vit D
Multivitamin, vitamin C, probiotics, fish oil
 
"If you can solve your problem, then what is the need of worrying? If you cannot solve it, then what is the use of worrying?"


Old Hat
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Date Joined Feb 2007
Total Posts : 5190
   Posted 1/9/2009 11:00 AM (GMT -6)   
pb4, I think the idea that most Crohn's occurs in people of Jewish descent will be debunked by more recent epidemiological studies that have yet to be published. That's basically what I heard from my gastro, who is a major U.S. researcher on IBD & treats tons of Crohn's cases, as well as UC. / Old Hat (nearly 30 yrs with left-sided UC ... [etc.])

pb4
Elite Member


Date Joined Feb 2004
Total Posts : 20577
   Posted 1/9/2009 1:50 PM (GMT -6)   
Old Hat, I highly doubt the relation of jewish descent and IBD will be debunked as more studies show from 2008...

Results shed light on special genetic vulnerabilities of Ashke**** Jews

What is believed to be the largest study of its kind for the genetic roots of inflammatory bowel diseases has suggested new links to Crohn’s Disease as well as further evidence that some people of Jewish descent are more likely to develop it.

The study examined changes in DNA associated with the two most common forms of inflammatory bowel disease (IBD): Crohn’s Disease (CD), which is most frequently marked by inflammation of the final section of the small bowel (ileum) and parts of the colon, and ulcerative colitis (UC), an inflammation of the internal lining of the rectum and colon.

Results of the study, published in this month’s edition of Genes and Immunity, included information gleaned from 993 families with IBD, 244 of whom were Ashke**** Jews. Up to 30 percent of people with IBD in the United States are estimated to have a family history of the condition, and about 25 percent of these families have both CD and UC in the family. People of Ashke**** Jewish descent are at least twice as likely to develop a form of IBD and are more likely to have familial disease.

“This increased risk for some Jewish people makes our study and results especially significant since this is the first sample size of Jewish families, 244, that was large enough to identify novel gene regions for familial predisposition in this ethnic group,” says Johns Hopkins gastroenterologist and genetic investigator Steven R. Brant, M.D., senior author of the study.

By analyzing common DNA variations known as single nucleotide polymorphisms, or SNPs, the team found evidence for genes causing familial Crohn’s Disease in the study population specific to Ashke**** Jewish families with CD on previously identified areas of chromosomes 1 and 3. They also identified a never-before-identified region of chromosome 13 that was shared by both Jewish and non-Jewish families with CD. Evidence for chromosomal regions that may be linked to UC on chromosome 2 and 19 for Jewish and non-Jewish families was also noted, according to Brant.

“What makes these results especially significant is not only the large sample size but also the method we used for screening, namely the use of a high-density, single-nucleotide polymorphism genome-wide linkage process, says Brant.” The new process is 10 times faster than older methods at searching the number of variations across the genome, he added.

Up to now, Brant says, no gene regions implicated in IBD were specific to Ashke**** families, and genetic evidence pointing to why Ashke**** Jews are twice as likely to get the disorder was lacking. The two genetic regions identified on chromosomes 1 and 3 were specific to Ashke**** CD and unrelated to known IBD genes.

Although further study is needed to narrow down which specific genes are the major players, Brant says it’s already clear that they are in the right “neighborhood” to search for IBD/CD susceptibility genes.

:)
My bum is broken....there's a big crack down the middle of it! LOL :)


Christine1946
Veteran Member


Date Joined Aug 2008
Total Posts : 5975
   Posted 1/9/2009 4:14 PM (GMT -6)   
     I read where IBD was prevalent among Jews too, but I have no Jewish blood as far as I know.   There is American Indian ancestry on dad's side too.  When his gggggggrandfather came from England he married an American Indian princess (story I was told anyway).  Mom's side from Poland. 

62 yr old granny. South Jersey
Diagnosed with ulcerative proctitis in 1998 in hospital
Hospitalized (2nd time) in May 2008
Update 11/03/08...finally in remission!!  Hope I don't jinx myself.  Off the prednisone since 11/01/08...now see if I can stay off for longer than two weeks.  Other meds: 6MP (75 mgm), colazal (6 per day), Benicar and Toprol (high blood pressure meds), Probiotic (2 per day), fish oil capsule and multi-vitamin and calcium with vitamin D.


pb4
Elite Member


Date Joined Feb 2004
Total Posts : 20577
   Posted 1/9/2009 6:16 PM (GMT -6)   
The info about jewish descent doesn't mean you have to be jewish in order to get an IBD, it just means that of all the races, jewish people have a higher tendancy to get an IBD but not all jewsish people will or do get it either.

:)
My bum is broken....there's a big crack down the middle of it! LOL :)


Old Hat
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Date Joined Feb 2007
Total Posts : 5190
   Posted 1/9/2009 10:45 PM (GMT -6)   
Jews are not a race, nor is 244 families that large a sample-- not even 1/3 of the total families that Brant claims to have studied. When investigative studies ask patients to check boxes as to whether they are Ashke**** or Sephardic Jews or descendents, my gastro asks the study designers: "What about everybody else who has IBD but does not fit into these categories?" It is a biased approach. / Old Hat (nearly 30 yrs with left-sided UC ... [etc.])

pb4
Elite Member


Date Joined Feb 2004
Total Posts : 20577
   Posted 1/9/2009 11:27 PM (GMT -6)   
I'm only going by all the research past and present that I've read regarding the relation to higher prevalance with those of jewish descent...it has no more to do with those that are not of jewish descent that do have an IBD it's simple research that shows those of jewish descent do have a higher tendancy to get an IBD and as I already mentioned it doesn't mean every jewish person will or does have it. It is was it is.

:)
My bum is broken....there's a big crack down the middle of it! LOL :)

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