My IBS symptoms are a bit different, but I'm sure both are in play when we're flaring. Depending on what we eat and where the inflammation is limited.
My doc had explained to me that it seems the lower (in the colon) the inflammation, the more gas, bloating and discomfort. I definitely felt better when I had diarrhea (higher into the sigmoid) than with a more formed stool starting to flare symptoms.
I do get nausea, but it's not only when I'm flaring. I do get low-grade fevers very often...could be related to my body clock or some inflammation or the fact that I have early UC-related liver disease. It could also be the meds? don't know.
I do have success with 5ASA meds, oral and rectal. I'm just flaring at this time, and the tummy bloating/gas/discomfort was painful before I recognised the obvious flaring. Once the multiple bms started, the gut discomfort was less, but the butt discomfort/throbbing increased (as norm with my flares). I take an antispasmodic that helps as well as a half of a Gravol which is an antinausea med.
It's unfortunate you didn't have success with so many of the meds you tried....I hope the imuran works for you.
You could consider to use maybe suppositories to help with the urgency and rectal inflammation...either steroid or 5ASA.
A fibre supplement can help with some of the discomfort as well as probiotics and adjusting your diet to ease some of the discomfot (some can be caused by your food intake).
If you're ingesting any artificial sweeteners, I'd suggest you stop them.
Welcome to the forum!
*Heather* Status..Asacol 6 (3 twice daily); enemas every 5th night
~diagnosed January 1989 UC (proctosigmoiditis)
~Bentylol (dicyclomine) 20mg as needed
~Probiotics....(Natural Factors Protec, Primadophilus Reuteri Pearls, Natural Factors Ultimate)....1 each @ bedtime
~various digestive enzymes as needed
~Ranitidine (reflux); Effexor XR 75mg(depression); Pulmicort/Airomir (asthma)
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS" worth it !!!