Ok, so some of you know that I work hard on this UC thing like white on rice floating in milk on a paper plate and I like to share my thoughts. I also like to hear the thoughts of intellectuals here as feedback. This site gives me more "real-world" experience with my fellow UC compatriots than any doc dialogue, med journal or textbook I can read. This is my own personal opinion based on what I've read, and would respect if it were taken as such. I know some here care little about
the cause. If this is true, this post is not for you.
I am not going to turn this into a biology lesson so I'm going to paraphrase a lengthy hypothesis.
I'm starting to think that IBD appears to be a multiconditional affliction based on multiple gene expressions requiring precise steps for activation to occur above and beyond IBS. It all seems to come down to genetic expression and the absorbtion of particles coupled with immune responses that may not be found in those with no GI disturbances or mild IBS.
One must first and foremost have the genetic potential to be at risk for IBD. It is this genetic predisposition that causes a defect or weakness in a normal intestinal wall's defenses. A pathogen (bacterium or virus) piggybacks on a particle (dust, dirt, food additives or dyes, and anti-caking agents, pollen, spores, etc.) is ingested, and passes through a faulty gut lining that seems to be localized only in the colon. This could perhaps explain why chronic seasonal IBD may have some merit as environmental contaminants are high at certain times. An inflammatory response is triggered as the body mounts defenses against the foreign substance.
For the IBS person a small bout of diarrhea, and/or mild allergy response may occur. Then, usually the bout is over and the body self-regulates. However, this may be where IBS stops and IBD takes over as another expression of genetics fails to control or stop the immune response. The unchecked immune response to whatever inflammed the gut wall causes ulceration rather than a small inconvinient bout of IBS symptoms.
So it is very possible that there may be multiple genes at work here and may also dictate the length and severity of flare, self-regulation, and may be difference between IBS and IBD. Just a thought...
Diagnosed w/ Ulcerative Colitis in 1995
32 years old
Living med free
Currently in remission