Weight gain AFTER Pred and ON 6-MP??

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Regular Member

Date Joined Oct 2008
Total Posts : 192
   Posted 12/31/2008 1:12 PM (GMT -6)   
I have been off Prednisone since 2 1/2 weeks and I am on 6-MP since a month. The best thing is that I am obviously in remission; although I am angered that I gained weight AFTER Pred. I was so proud that I didn't gain WHILE on Pred.
While tapering down to 5 mg of Pred, I already felt that my apetite was increasing and that I felt bloated most of the time. So it is been 17 days off the Pred and I wonder whether my increase of apetite and weight gain (almost a whooping 10 lbs) was caused still by the Pred OR if 6-MP causes also weight gain? Any ideas?
I still have a moon face and I am pretty angry about the weight gain, but it seems that I am hungry all the time and although I am pretty good at pacing myself, I still gain weight and I don't eat junk food. I still feel bloated most of the time and I know that the weight gain is no water rentention, because I can always tell by the size of my thighs if I retain water or gained fat tissue.
How long does it take to get the Pred (and its effects) out of the system? I have taking it for 10 weeks on an initial dose of 40 mg.
Has anyone gained weight on 6-MP or had to deal with a slower metabolism?
Happy new year and I will be grateful for hearing your ideas and experiences!
Scarlett, 38 yo., TX
Pancolitis since 3/1997
Worst flare of my life from 8/2008 until mid 12/2008 - bye bye flare! Was about friggin' time ...
6 x Asacol a day
0 mg Prednisone (stopped Dec 14, 2008)
75mg 6-MP (started Dec 1, 2008)
Flintstones Complete Vitamins

Regular Member

Date Joined Oct 2007
Total Posts : 135
   Posted 12/31/2008 1:34 PM (GMT -6)   
I've been off of Prednisone for close to a year now and I still have most of the weight that I gained while on it (went from 200 pounds to 260).  I've been working like a dog lately to drop the weight and so far I've lost about 15 pounds.  But from what people say I guess it depends on the individual.  Some have lost their Prednisone weight as soon as they stopped taking it whereas others still have it, like me.
Pancolitis - Diagnosed on 9/6/07
Asacol 4 pills 3x's daily
Imuran 150mg.
Calcium with Vit. D Tablets

Veteran Member

Date Joined Aug 2008
Total Posts : 5951
   Posted 12/31/2008 1:56 PM (GMT -6)   
     I have always lost weight but this could be due to the ulcerative proctitis and the diarrhea even while on prednisone.  I've gained a lot of my weight back...I was 141 initially, went down to 125 while flaring and now up to 132.  I really don't want to gain any more weight.  I don't think 6MP makes you gain weight.  I take toprol xl for blood pressure and that is a beta blocker which slows the heart rate, therefore must slow metabolism.
62 yr old granny. South Jersey
Diagnosed with ulcerative proctitis in 1998 in hospital
Hospitalized (2nd time) in May 2008
Update 11/03/08...finally in remission!!  Hope I don't jinx myself.  Off the prednisone since 11/01/08...now see if I can stay off for longer than two weeks.  Other meds: 6MP (75 mgm), colazal (6 per day), Benicar and Toprol (high blood pressure meds), Probiotic (2 per day), fish oil capsule and multi-vitamin and calcium with vitamin D.

Veteran Member

Date Joined Aug 2008
Total Posts : 903
   Posted 1/1/2009 10:21 AM (GMT -6)   
I was on Prednisone twice in 2007, and the second time I gained 10 pounds while on it. I too am on I guess 6 mp meds. (Imuran) Haven't seen any weight gain with that drug. I ended up losing the 10 pounds in May 2008, due to a minor flare. oh well, at least the weight went down. I'm sure the prednisone gave you the weight.
26 year old, Married, Female.
Diagnosed with UC since March 2007
Taking Humira and Imuran since May 2007 (Currently in remission since May 2007)

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